ESPE Abstracts

Background: Central precocious puberty (CPP) manifests through the activation of the hypothalamic-pituitary-gonadal axis before the age of 8 in girls and is increasing worldwide, but its causes and prevention methods remain mostly unclear. Premature thelarche (PT) is a benign condition but needs to be differentiated from CPP.Objective: To investigate the microRNA (miRNA) expression profiles in CPP and distinguish it from...

Objective: To investigate whether the early-life overweight/obesity trajectory from ages 2, 4, to 8 affects insulin resistance (IR) in 8-year-old prepubertal children.Methods: From the Environment and Development of Children (EDC) cohort, 262 prepubertal children (147 boys and 115 girls) who visited Seoul National University Children’s Hospital for anthropometric measurements at ages 2, 4 and 8 were included. At ag...

Background: Leptin, ghrelin, and nesfatin-1 are peptide hormones which regulates food intake, energy homeostasis and growth hormone synthesis.Objectives: To evaluate the relationship between leptin, ghrelin and nesfatin-1 with catch-up growth (CUG) in children born small for gestational age (SGA).Methods: A total of 67 children were included; 34 children born SGA without CUG, 17 ch...

Background: Small for gestational age (SGA) children are defined by birth weight and/or length at least 2 standard deviations (S.D) below the population mean for gestational age. Up to 90% of these infants experience catch-up growth within the first two years of life; however, 10-15% fail to do so, remaining short at age 2 (SGA-SS). The etiology of failure to achieve catch-up growth remains largely unknown.Methods: This ...