hrp0086p1-p234 | Diabetes P1 | ESPE2016

Assessment of Selected Carbohydrate Parameters in Children Exposed to Gestational Diabetes in utero

Wilk Malgorzata , Horodnicka-Jozwa Anita , Moleda Piotr , Petriczko Elzbieta , Safranow Krzysztof , Chojnacka Hanna , Gawrych Elzbieta , Walczak Alicja , Walczak Mieczyslaw

Background: Children exposed to gestational diabetes mellitus (GDM) in utero have higher risk of development of glucose intolerance and diabetes mellitus.Objective and hypotheses: The study was undertaken to assess the selected carbohydrate parameters in children exposed to gestational diabetes in utero.Method: 50 children exposed to gestational diabetes were compared with 46 control subjects. Anthropometric parameters of a newborn...

hrp0084p2-525 | Puberty | ESPE2015

The Lack of MKRN3 Gene Mutations in Patients with Idiopathic Sporadic GnRH-Dependent Precocious Puberty

Wikiera Beata , Pesz Karolina , Petriczko Elzbieta , Nocon-Bohusz Julita , Urbanowicz Ewa , Walczak Mieczyslaw , Sasiadek Maria , Noczynska Anna

Background: Central precocious puberty (CPP) results from activation of the hypothalamic-pituitary-gonadal axis before the age of 8 years in girls and 9 years in boys. The molecular basis of the maturation of this axis is still poorly understood. The MRKN3 gene located in the Prader-Willi syndrome critical region (chromosome 15q11–q13), inhibit factors stimulating pulsative. GnRH secretion. In 2013 inactivating mutations in the MRKN3 gene were discovered...

hrp0089p2-p141 | Fat, Metabolism and Obesity P2 | ESPE2018

Associations between Total Leptin, Bio-inactive Leptin, Soluble Leptin Receptor and Anthropometrics in Children with Severe Early-onset Obesity (SEOO) – the German-Polish Study (EOL-GPS)

Zachurzok Agnieszka , Malecka-Tendera Ewa , Petriczko Elzbieta , Mazur Artur , Pridzun Lutz , Flehmig Bertram , Schnurbein Julia von , Ranke Michael B. , Wabitsch Martin , Brandt Stephanie

Background: Severe early-onset obesity (SEOO) in children is more frequently observed in subjects with genetic disorders of which those of leptin pathway can be analyzed biochemically and genetically.Objectives: The aim of the study was to investigate anthropometrics and leptin parameters, specifically searching for bio-inactive leptin, in children with SEOO.Methods: Study cohort includes children ...

hrp0084p1-148 | Miscelleaneous | ESPE2015

The Analysis of Occurrence the Zinc Transporter Antibodies ZnT8 in Children with Graves’ Disease and Hashimoto’s Thyroiditis

Bossowski Artur , Borysewicz-Sanczyk Hanna , Bossowska Anna , Szalecki Mieczyslaw , Kucharska Anna , Pyrzak Beata , Walczak Mieczyslaw , Petriczko Elzbieta , Ziora Katarzyna , Del Pilar Larosa Maria , Chen Shu , Powell Michael , Furmaniak Jadwiga , Smith Bernard Rees

Introduction: Recent studies have revealed the presence of zinc and the expression of zinc transporter (ZnT) family members in most endocrine cell types. Moreover it was demonstrated that the ZnT family plays an important role in the synthesis and secretion of many hormones like insulin. We studied the prevalence of ZnT8 Ab in patients with autoimmune thyroid diseases (AITD).Material and methods: The study was performed in the group consisting of 20 Grav...