hrp0095p1-138 | Multisystem Endocrine Disorders | ESPE2022

Long-term Growth and Endocrine Complications of Bone Marrow Transplantation in Children and Adolescents with Beta-Thalassemia Major: Comparison with Conventional treatment

Ahmed Shayma , Soliman Ashraf , Alaaraj Nada , Hamed Noor

Introduction: The conventional approach to the treatment of Beta- thalassemia major (BTM) is based on the correction of hemoglobin status through regular blood transfusions and iron chelation therapy for iron overload. Allogeneic hematopoietic stem cell transplantation (HCT) remains the only currently available technique that has curative potential. No previous study compared the long-term growth and endocrinopathy changes among large cohorts of BTM patients o...

hrp0095p2-100 | Fat, Metabolism and Obesity | ESPE2022

Comparison between Triglyceride-Glucose Index (TyG) and Atherogenic index of plasma (AIP) in relation to the different components of the metabolic syndrome (MetS) in morbidly obese children

Hamed Noor , Soliman Ashraf , Alaaraj Nada , Ahmed Shayma

Background: Metabolic syndrome (MetS) is related to increased cardiovascular complications of obesity. The triglyceride-glucose (TyG) index is frequently used as an indicator of insulin resistance in adults. However, there is scant information on the TyG index in the morbidly obese Pediatric population, nor is its correlation with the components of the metabolic syndrome (MetS).Methods: We compared the use of TyG vs athe...

hrp0092p2-43 | Bone, Growth Plate and Mineral Metabolism | ESPE2019

A Rare Form of Vitamin D Receptors Dysfunction (vitamin D-dependent Rickets Type II) with Alopecia. A Case Report

Ahmed Shayma , Soliman Ashraf , Elawwa Ahmed , Hamed Noor , Alaaraj Nada

Introduction: VDDR II is an autosomal recessive disorder caused by a defect in the vitamin D receptor gene located on chromosome 12q12–q14. Thus far, 13 mutations have been identified. It is characterized by hypocalcemia, secondary hyperparathyroidism, and early onset severe rickets. Here we report a case of a severe form of rickets associated with alopecia.The Case: This 23-month-old boy was born at term to consang...

hrp0089p3-p120 | Diabetes & Insulin P3 | ESPE2018

Oral Gliclazide (A Sulfonylurea) Monotherapy is Effective and Safe in the Management of T2DM in Children: A Case Report

Ahmed Shayma , Soliman Ashraf , Alaaraj Nada , Hamad Noor

Introduction: Most of the oral medications available for treating type 2 diabetes (T2DM) have not been studied in children. T2DM in pediatric patients is usually treated with metformin and insulin. The use of other oral antidiabetic drugs is not clearly delineated in T2DM in children although potentially useful.Case report: A 13 year-old girl, presented with polyuria, polydipsia and weight loss (5 kg) for 2 weeks before presentation. Her Weight=65.7 kg, ...

hrp0094p2-415 | Sex differentiation, gonads and gynaecology or sex endocrinology | ESPE2021

Obesity, ovarian mass, vaginal bleeding and hypothyroidism in a 5-year-old female girl

Alhemaidy Noora , Alaaraj Nada , Soliman Ashraf , Hamed Noor , Ahmed Shayma

Introduction: Van Wyk-Grumbach Syndrome (VWGS) is a constellation of symptoms including precocious puberty without adrenarche, delayed bone age, ovarian cysts, and hypothyroidism.Case report: We report here a five-year-old girl who presented for evaluation of obesity, abdominal distension, vaginal bleeding, and abdominal distention. Her HtSDS =-1.3 and BMI SDS =1.5. A large abdominal mass was palpable. She had no breast development or pubic hair. Her Inv...

hrp0094p2-378 | Pituitary, neuroendocrinology and puberty | ESPE2021

The effect of 3 years of Gonadotropin-Suppressive Therapy in Girls with Early Puberty: Height Z Score in Relation to Mid-Parental height Z score.

Alaaraj Nada , Soliman Ashraf , Hamed Noor , Ahmed Shayma , Alyafei Fawzia ,

Introduction: Early and fast puberty (EFP) in girls, defined as pubertal onset at age 8-9 yr., with an accelerated course, may cause compromised final adult height (FAHt). Treatment with a gonadotropin-suppressive agent is still controversial because the improvement in FAHt is equivocal and there may be a risk of overweight.Aim of the study: We analyzed the data of 24 girls with EFP treated with GnRH analog (GnRH) since Tanner stage 2-3,...

hrp0094p2-389 | Pituitary, neuroendocrinology and puberty | ESPE2021

Atypical Presentation of Pituitary Macroadenoma in an adolescent girl: Central Hypothyroidism and Attenuated Pubertal Growth Spurt.

Alaaraj Nada , Soliman Ashraf , Hamed Noor , Ahmed Shayma ,

Introduction: Hyperprolactinemia (HPrl) secondary to macroadenoma is a rare endocrinopathy in childhood but represents one of the most frequent forms of pituitary adenoma.Case report: A 12yr old girl was referred for assessment of progressive weight gain in the last 1.5 years. Despite trials of weight control by changing the dietary habit and daily exercise weight her BMI SDS increased from 1.2 to 2.2. This was associated with progressiv...

hrp0097p1-89 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Maternal, placental and fetal IGF-1/IGFBP in Diabetic pregnancies and their effect on fetal/infantile growth

Soliman Ashraf Alaaraj Nada , Ahmed Shayma , Alyafei Fawzia , Soliman Ashraf

Introduction: In diabetic pregnancies, data about the interaction between maternal, placental, and fetal IGF1/IGFBP in relation to newborn size is not clear,Aim: To review research papers published in Pubmed, Google scholar, Research gate, and Scopus in the past 20 years on the relation between placental IGF1/IGFBP-1 and fetal/infantile/childhood growth in pregnancies associated with maternal diabetes.<p class="abste...

hrp0097p1-107 | GH and IGFs | ESPE2023

The Growth Predictive Value of (IGF1/Growth Hormone Peak) Ratio in Children with Idiopathic Short Stature (ISS)

Soliman Ashraf , Alyafei Fawzia , Alaaraj Nada , Hamed Noor , Ahmed Shayma

Introduction: Stimulated GH peak values have been shown to correlate well with nocturnal GH peak values and with nocturnal mean GH values. In addition, the expression level of serum IGF-1 in ISS has been shown to be significantly lower than that in normal children despite their normal GH peak response to provocation. GH stimulates the production of IGF1; however, their metabolic effects are different. GH has lipolytic and anti-insulin actions while IGF1 has in...

hrp0097p1-125 | Growth and Syndromes | ESPE2023

Significant Linear Growth Impairment in a carrier of an interstitial deletion of *356-kb within cytogenetic band 22q11.21 with good response to growth hormone therapy.

Soliman Ashraf , Alaaraj Nada , Alyafei Fawzia , Hamed Noor , Ahmed Shayma

Introduction: The 22q11 deletion is one of the most commonly recognized deletion syndromes in humans (~ 1/4000 live births). Most of the reported defect generally involves a deletion at breakpoints LCR22A and LCR22D causing DiGeorge or velo-cardio-facial syndrome. In deletion syndromes, the phenotype ranges from unspecified dysmorphic features to severe cognitive/behavioral deficits, but normal features can occur depending on the size and amount of gene dosage...