hrp0089p2-p102 | Diabetes & Insulin P2 | ESPE2018

A Novel Missense Variant, p.(Thr405Arg), in the SLC19A2 Gene in an Infant with Thiamine Responsive Megaloblastic Anemia Syndrome Presenting with Anemia and Diabetes but with Normal Hearing

Spehar Uroic Anita , Milenkovic Dragan , De Franco Ellisa , Rojnic Putarek Natasa , Krnic Nevena

Objectives: Thiamine responsive megaloblastic anemia syndrome (TRMA) is characterized by the clinical triad of megaloblastic anemia, non-immune diabetes mellitus and sensorineural deafness. It is a very rare autosomal recessive disease with an increased frequency in consanguineous marriages and isolated communities. The syndrome is due to intracellular thiamine deficiency which is the result of a defective high affinity low performance thiamine transporter pro...

hrp0095p1-460 | Diabetes and Insulin | ESPE2022

Assessing the clinical effectiveness of advanced hybrid closed loop insulin pump therapy and calibration-free glucose sensor - experience of a single centre, Arendal, Norway

Rojnic Putarek Natasa , Schmidt Katharina , Henrik Augustsson Johan , Hurvenes Moen Hilde , Spehar Uroic Anita

Introduction: Automated insulin delivery has demonstrated improved glycemic control in children and adolescents with type 1 diabetes mellitus (T1DM). The present analysis investigates real-world glycemic outcomes in children and adolescent on the MiniMedâ„¢ 780G advanced hybrid closed loop (AHCL) system after switching from MiniMedâ„¢ 640G predictive low glucose suspend system (PLGS) or MiniMed 670G hybrid closed loop (HCL) system and calibration-free ...

hrp0095p1-262 | Fat, Metabolism and Obesity | ESPE2022

Altered inflammatory parameters and chemokine network in obese children

Spehar Uroic Anita , Filipovic Masa , Sucur Alan , Krnic Nevena , Grcevic Danka

Background: Childhood obesity has increased in epidemic proportions worldwide. Growing evidence confirms persistent low-grade systemic inflammation in obese individuals. It eventually leads to insulin resistance and endothelial damage, thus setting the ground for the development of metabolic and vascular complications.Aim: To investigate metabolic and inflammatory parameters and their relationship in obese children, by a...

hrp0095p2-61 | Diabetes and Insulin | ESPE2022

Ketoacidosis and Age Distribution in New-Onset Type 1 Diabetes During Covid-19 Pandemic

Vinkovic Maja , Krnic Nevena , Bogdanic Ana , Dumic Kubat Katja , Braovac Duje , Spehar Uroic Anita

Background:There are numerous reports indicating increased risk of diabetic ketoacidosis (DKA) in new-onset type 1 diabetes (T1D) in childhood during COVID-19 pandemic. Delayed diagnosis, reduced access to immediate health care and psychological effects of pandemic have been suggested as possible reasons.Methods: We conducted cross sectional, single-center study at Department of Pediatrics, University Hospital Center Zag...