ESPE Abstracts

Introduction: Diploid/triploid mosaicism is an uncommon clinical syndrome presenting with developmental retardation and a distinctive phenotype: prenatal and postnatal asymmetric growth deficiency, distinctive facial dysmorphism, hands and feet malformations with a wide sandal gap, pigmentary dysplasia, hypotonia and hypotrophy of the musculature, and truncal obesity. However, metabolic syndrome was not reported in these patients. Diploid/triploid mosaicism ma...

Introduction: Automated insulin delivery has demonstrated improved glycemic control in children and adolescents with type 1 diabetes mellitus (T1DM). The present analysis investigates real-world glycemic outcomes in children and adolescent on the MiniMed™ 780G advanced hybrid closed loop (AHCL) system after switching from MiniMed™ 640G predictive low glucose suspend system (PLGS) or MiniMed 670G hybrid closed loop (HCL) system and calibration-free ...

Background: Childhood obesity has increased in epidemic proportions worldwide. Growing evidence confirms persistent low-grade systemic inflammation in obese individuals. It eventually leads to insulin resistance and endothelial damage, thus setting the ground for the development of metabolic and vascular complications.Aim: To investigate metabolic and inflammatory parameters and their relationship in obese children, by a...

Background:There are numerous reports indicating increased risk of diabetic ketoacidosis (DKA) in new-onset type 1 diabetes (T1D) in childhood during COVID-19 pandemic. Delayed diagnosis, reduced access to immediate health care and psychological effects of pandemic have been suggested as possible reasons.Methods: We conducted cross sectional, single-center study at Department of Pediatrics, University Hospital Center Zag...

Objectives: Thiamine responsive megaloblastic anemia syndrome (TRMA) is characterized by the clinical triad of megaloblastic anemia, non-immune diabetes mellitus and sensorineural deafness. It is a very rare autosomal recessive disease with an increased frequency in consanguineous marriages and isolated communities. The syndrome is due to intracellular thiamine deficiency which is the result of a defective high affinity low performance thiamine transporter pro...

Childhood obesity has increased in epidemic proportions worldwide. Complications of obesity represent a growing proportion of childhood morbidity. Albuminuria resulting from endothelial damage was recognized as a complication of obesity, implying higher cardiovascular risk.Aim: to investigate the association of albuminuria in obese children with metabolic and inflammatory parameters.Materials and Methods:</...

Background: Type 1 diabetes (T1D), as one of the most common chronic autoimmune diseases, can have significant negative impact on pubertal development and overall reproductive health. Girls with T1D have been reported with delayed onset of menarche, in relation to premenarchal onset of T1D, inadequate metabolic control, insulin dosage, and duration of diabetes.Methods: We conducted a retrospective cross-sectional single-...