hrp0095p1-126 | Growth and Syndromes | ESPE2022

Earlier menarche of mothers as a risk factor for daughters’ early age at menarche and short stature in young Korean females: an epidemiologic study

Sub Lim Jung , Hyun Kim Ji

Background: Early age at menarche was associated with obesity, insulin resistance, metabolic syndrome, cardiovascular disease (CVD), and mortality in adulthood. Besides, a mother's age at menarche has been suggested to be a likely contributor to a daughter's early menarche. Therefore, this study aimed to determine whether a mother's earlier age at menarche is a risk factor for a daughter's early menarche, obesity, and short stature in young...

hrp0095p1-427 | Bone, Growth Plate and Mineral Metabolism | ESPE2022

The mutation of the FGFR3 gene causes familial acanthosis nigricans with hypochondroplasia syndrome

Sang Lee Hae , Suk Shim Young , Sub Lim Jung

Objective: Acanthosis nigricans (AN) is characterized by velvety and papillomatous pigmented hyperkeratosis of the flexures and neck. Mutations in fibroblast growth factor receptor 3 (FGFR3) gene have been identified as one of the causes of skeletal dysplasia with AN. However, there have been few reports about familial AN with hypochondroplasia. Here we report a familial case with FGFR3 gene mutation.Case reports: A 16-y...

hrp0095p1-75 | Fat, Metabolism and Obesity | ESPE2022

The association between C-reactive protein, metabolic syndrome, and prediabetes in Korean children and adolescents

Hyun Kim Ji , Bin Lee Jong , Sub Lim Jung

Purpose: Metabolic syndrome (MetS) is a state of chronic inflammation, and high-sensitivity C-reactive protein (hsCRP) indicates inflammation. This paper evaluates the association between hsCRP and MetS and its components in Korean children and adolescents.Methods: We analyzed the data of 1,247 subjects (633 males, 14.2 ± 2.7 years) from the Korea National Health and Nutrition Examination Survey (KNHANES) 2016-2017. T...

hrp0095p1-157 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Effect of gonadotropin-releasing hormone agonist monotherapy and combination therapy with growth hormone on final adult height in girls with central precocious puberty

Sang Lee Hae , Young Cho Ah , Suk Shim Young , Sub Lim Jung , Soon Hwang Jin

Objective: This study aimed to compare clinical parameters, including final adult height (FAH), in girls with central precocious puberty treated with gonadotropin-releasing hormone agonists (GnRHa) with and without growth hormone (GH).Methods: This retrospective study reviewed data of 210 girls with precocious puberty who had reached FAH in a long-term trial of GnRHa treatment. The subjects were divided into the GnRHa tr...

hrp0095p1-343 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Subcutaneous Triptorelin stimulation test for diagnosing central precocious puberty in girls

Sang Lee Hae , Suk Shim Young , Sub Lim Jung , Soon Hwang Jin

Objective: Central precocious puberty (CPP) is defined as early activation of the hypothalamic-pituitary-gonadal axis. The gonadotropin releasing hormone (GnRH) stimulation test has become widely used in the evaluation of CPP. However, intravenous GnRH is often not readily available for commercial use. Therefore, we aimed to evaluate the diagnostic accuracy of the Triptorelin test compared to the GnRH test.Methods: A tot...

hrp0092p2-175 | Growth and Syndromes (to include Turner Syndrome) | ESPE2019

The Impact of Growth Hormone Treatment in Patients with Noonan Syndrome and Growth Hormone Deficiency

Sang Lee Hae , Bae Sohn Young , Dae Kum Chang , Sub Lim Jung , Soon Hwang Jin

Purpose: Noonan syndrome (NS) is a genetic disorder characterized by specific features including short stature, cardiac defect, and distinctive facial dysmorphism. Human growth hormone (GH) has been used to improve growth in children with NS but there is little information how GH treatment affects height. The aim of this study is to investigate efficacy of GH treatment in Korean children with NS compared to sex and age-matched patients with growth hormone defi...

hrp0082p1-d2-212 | Reproduction (1) | ESPE2014

A Novel MKRN3 Mutation Discovered in a Korean Girl with Central Precocious Puberty

Sang Lee Hae , Sub Lim Jung , Soon Hwang Jin , Young Kim Eun

Context: It has recently been shown that mutations of MKRN3, the gene encoding makorin RING-finger protein 3, lead to central precocious puberty (CPP). The aim of this study was to investigate mutations of the MKRN3 gene in Korean girls with CPP.Methods: Two hundred and sixty Korean girls with idiopathic CPP were included in this study. Auxological and endocrine parameters were measured. The entire MKRN3 gene was directly seque...

hrp0097p1-463 | Fat, Metabolism and Obesity | ESPE2023

Association between lean mass and metabolic syndrome risk in Korean children and adolescents

Suk Shim Young , Sang Lee Hae , Rim Jeong Hwal , Sub Lim Jung , Soon Hwang Jin

Introduction: Skeletal muscle plays a crucial role in glucose disposal, and studies have shown a positive relationship between muscle mass and insulin sensitivity. However, an elevated lean mass has also been associated with metabolically adverse outcomes. This study aimed to evaluate the association between the risk of metabolic syndrome (MetS) and lean mass using dual-energy X-ray absorptiometry (DXA) in a nationally representative sample from the Korea Nati...

hrp0097p1-498 | GH and IGFs | ESPE2023

The relationship between body mass index and therapeutic effect in children with idiopathic growth hormone deficiency

Sang Lee Hae , Suk Shim Young , Soon Hwang Jin , Sub Lim Jung

Purpose: The aim of this study is to investigate the influence of body mass index (BMI) on therapeutic effect in prepubertal children with idiopathic growth hormone deficiency (IGHD).Methods: We conducted a retrospective study by chart review in a single center. A total of 138 patients (male n=90, female n=48) with idiopathic growth hormone deficiency who were was treated growth hormone for at least 2 y...

hrp0097p1-353 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Clinical features of hyperprolactinemia in children and adolescents

Sang Lee Hae , Suk Shim Young , Sub Lim Jung , Soon Hwang Jin

Background/Purpose: Hyperprolactinemia is a rare endocrine disorder in childhood and there are limited etiological, clinical, and demographic data. The purpose of this study was to evaluate the clinical features and course of hyperprolactinemia in childhood and adolescents and to help diagnose and plan the management.Methods: In this single-center retrospective study included 21 patients with hyperprolactinemia from Ajou...