hrp0082p2-d3-401 | Fat Metabolism & Obesity (2) | ESPE2014

Mannose Binding Lectin and Carotid Intima–Media Thickness in Chinese Obese Children

Wu Wei , Cheng Liqing , Fu Junfen

Background: Mannose binding lectin (MBL) is an important innate immune molecule and is previously found to be related to artery damage in some diseases as SLE rheumatoid arthritis and severe atherosclerosis. However, its role in artery change is still contradictory according to different studies. We found the carotid intima–media thickness (CIMT) increased in obese children which indicated an early change of atherosclerosis.Objective and hypotheses:...

hrp0095rfc9.4 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Association of Birth Size, Dehydroepiandrosterone Sulfate and Cardiometabolic Risk Factors in Idiopathic Central Precocious Puberty Girls

Zhang Guijiao , Yu Huan , Yu Shengxu , Luo Xiaoping , Wu Wei

Background: Early timing of puberty is associated with worse cardiometabolic health in adulthood. Furthermore, birth weight (BW) is recognized to have implications for pubertal development and cardiometabolic risk factors. The study aimed to examine the independent association between birth size, dehydroepiandrosterone sulfate (DHEAS) and cardiometabolic risk factors in idiopathic central precocious puberty (ICPP) girls.Methods:<...

hrp0089p1-p097 | Fat, Metabolism and Obesity P1 | ESPE2018

Circulating Exosomal miRNAs Involved in the Pathogenesis of Children Nonalcoholic Steatohepatitis

Zhou Xuelian , Fu Junfen , Dong Guanping , Huang Ke , Wu Wei

Circulating Exosomal miRNAs involved in the Pathogenesis of Children Nonalcoholic Steatohepatitis.Background: The incidence of children non-alcoholic fatty liver disease (NAFLD) increased rapidly paralleled with the global burden of obesity and diabetes. Although most patients are nonalcoholic fatty liver, there are still a small part of them will progress to nonalcoholic steatohepatitis (NASH), fibrosis and cirrhosis. However, the diagnosis of NASH is b...

hrp0089p3-p216 | GH &amp; IGFs P3 | ESPE2018

Efficacy and Safety of Recombinant Human GH in Treating Chinese Children with Idiopathic Short Stature

Ying Yanqin , Hou Ling , Yan Liang , Wu Wei , Luo Xiaoping

This study aims to investigate the efficacy and safety of recombinant human GH (rhGH) in the treatment of idiopathic short stature (ISS).Methods: The data of 200 ISS children, who were treated with rhGH from January 2008 to December 2016, were collected and retrospectively analyzed. The data of height, bone age, blood glucose, insulin, thyroid function and IGF-1 were collected, and annual growth rate (AGR), height standard deviation score (HtSDS) and rel...

hrp0089p3-p217 | GH &amp; IGFs P3 | ESPE2018

Comparison the Recombinant Human GH (rhGH) Treatment in Children with Idiopathic Short Stature (ISS) and GH Deficiency (GHD)

Ying Yanqin , Hou Ling , Liang Yan , Wu Wei , Luo Xiaoping

Background: The efficacy and safety of rhGH treatment on ISS and GHD were not reported in Chinese children. In this study, we aimed to compare the efficacy and safety of rhGH therapy in ISS and GHD.Methods: The clinical data in children with ISS and GHD who were treated with rhGH for more than one year from 2005 to 2016 were retrospectively analyzed. Growth velocity (GV), HtSDS, IGF1 SDS, BMI and the incidence of fasting hyperglycemia, fasting hyperinsul...

hrp0089p1-p256 | Thyroid P1 | ESPE2018

Mutation Screening in 60 Chinese Patients with Congenital Hypothyroidism

Zheng Zhangqian , Lu Wei , Wu Jing , Luo Feihong

Objectives: Congenital hypothyroidism (CH) is the most common neonatal endocrine disorder in infancy. The aim of this study was to screen for reported gene mutations among CH patients in our hospital and to illustrate a genetic mutation spectrum of CH in China.Methods: We designed a gene panel consisting of more than 20 relevant genes including TSHR and DUOX2. Blood samples were collected from 60 CH patients and their parents in Children’s Hospital ...

hrp0086p2-p94 | Adrenal P2 | ESPE2016

11β- Hydroxylase Deficiency due to a Novel Compound Heterozygous Mutation and Literature Review

Wu Wei , Dong Guanping , Li Yun , Wang Jinling

Background: The incidence of 11β-hydroxylase deficiency is quite low in China, less is reported about the gene mutation in Chinese population.Objective and hypotheses: To analyze the clinical features and CYP11B1 gene mutations of a family with 11β-hydroxylase deficiency (11β-OHD) and literature review were also included.Method: Physical examination and laboratory tests were done on a 4 years old girl and gene mutati...

hrp0097p1-354 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

The effect of leuprolide acetate 11.25mg 3-month formulation in children with central precocious puberty: A systematic review and meta-analysis

Wu Wei , Huang Ke , Dong Guanping , Fu Junfen

Background: Central precocious puberty (CPP) results from the premature pubertal activation of the hypothalamic-pituitary-gonadal axis before eight years for girls or nine years for boys. A systematic review and meta-analysis was conducted to evaluate the long-term efficacy and safety of leuprolide acetate (LA) 11.25mg 3-month formulation in children with CPP.Methods: A systematic search in PubMed and Embase was conducte...

hrp0092rfc1.5 | Diabetes and Insulin Session 1 | ESPE2019

Decreased Circulating Levels of MOTS-c in Individuals with Newly Diagnosed Type 1 Diabetes Children

Du Caiqi , Zhang Cai , Liang Yan , Wu Wei , Hou Ling , Luo Xiaoping

Background and Aims: A novel bioactive peptide, mitochondrial-derived peptide (MOTS-c), has recently attracted interests as a potential prevention or therapeutic option for obesity and type 2 diabetes mellitus in mice. MOTS-c profiles have not yet been reported in type 1 diabetes (T1DM). We aimed to determine circulating MOTS-c levels in T1DM and explore the association between MOTS-c levels and various metabolic parameters.Metho...

hrp0092p1-200 | Fat, Metabolism and Obesity (1) | ESPE2019

Ferritin, an Indicator for Inflammation or Iron Storage in Obese Children?

Wu Wei , Yuan Jinna , Yu Yunxian , Shen Yu , Dong Guanping , Huang Ke , Zhang Li , Fu Junfen

Ferritin is a widely used iron storage indicator. At the same time, it is also viewed as an indicator of inflammation. Chronic low-grade inflammation in obese individual, especially in the one with metabolic disorders, related to comorbidities and poor prognosis. Both hyperglycemia and iron overload can induce inflammation and result in vascular endothelial dysfunction. To study the role of ferritin in obese children and its impact on artery and liver, the present study invest...