hrp0098p1-299 | Late Breaking 1 | ESPE2024

A Real-World Pharmacovigilance Assessment and Literature Review of Lymphoma Development in Lipodystrophy and Congenital Leptin Deficiency

J. Brown Rebecca , Araujo-Vilar David , Walkovich Kelly , Barbarosie Alexandru , A. Magee David , Akinci Baris , A. Oral Elif

Introduction: Metreleptin is a leptin replacement therapy used as an adjunct to diet to treat the metabolic complications of leptin deficiency in lipodystrophy, a rare disease characterised by loss of adipose tissue. Previously, identification of T-cell lymphomas in three metreleptin-treated patients with acquired generalised lipodystrophy (AGL) led to concerns of a potential link between metreleptin and lymphoma development.Meth...

hrp0082p2-d1-518 | Pituitary | ESPE2014

Goliath, a Variant of DAVID Syndrome?

Hasselmann Caroline , Samuels Mark E , Van Vliet Guy

Background: DAVID syndrome (deficit in anterior pituitary function and variable immune deficiency) (J Clin Endocrinol Metab 97 E121, 2012) can be caused by NFKB2 mutations (Am J Hum Genet 93 13, 2013). All patients have an orthotopic posterior pituitary (PP) and most only ACTH deficiency.Objective and Hypothesis: To describe a girl with common variable immunodeficiency (CVID), ectopic PP (EPP) ...

hrp0086p2-p504 | Fat Metabolism and Obesity P2 | ESPE2016

Analysis of Circulating miRNAs in Obese Children Born Small for Gestational Age

Faienza Maria Felicia , Marzano Flaviana , Inzaghi Elena , Annese Anita , Caratozzolo Mariano Francesco , D'Erchia Annamaria , Chiara Matteo , Horner David , Sbisa Elisabetta , Cavallo Luciano , Pesole Graziano , Tullo Apollonia , Cianfarani Stefano

Background: Children born small for gestational age (SGA) are at increased risk of coronary heart disease and type 2 diabetes in adulthood, due to reprogramming of endocrine and metabolic functions. Dysregulation of specific miRNAs in response to genetic and environmental factors contribute to aberrant gene expression patterns underlying metabolic dysfunction.Objective and hypotheses: We aimed to identify miRNAs associated with increased risk of obesity ...

hrp0092s4.1 | ISPAD/Complications of Type 1 Diabetes | ESPE2019

Hypoglycemia in Children with T1D: Past, Present, and Future

Maahs David

Among the many complications of type 1 diabetes (T1D), hypoglycemia is an acute concern for children with T1D and their families. Moreover, fear of hypoglycemia is a common barrier to achieving glucose targets. Numerous advances in care have been made since the Diabetes Control and Complications Trial was published in 1993 in which lower HbA1c was associated with increasing risk of severe hypoglycemia. More recent data indicate that lower HbA1c (7% ISPAD target) can be ach...

hrp0089s6.2 | Molecular Mechanisms of Tissue Sensitivity to Glucocorticoids: Potential Clinical Implications | ESPE2018

Immune Regulation by Glucocorticoids

Ray David

Glucocorticoids (cortisol in humans, corticosterone in rodents) are critical regulators of energy metabolism and immunity. Their secretion by the adrenal gland follows a circadian pattern, with serum concentrations peaking before the active phase (day in humans, night in rodents). Synthetic glucocorticoids are the most potent anti-inflammatory agents known, and are widely used therapeutically, with >1% of the UK population holding a prescription long-term. However, frequen...

hrp0086s8.3 | Stem cells in endocrine organs | ESPE2016

Hubs in the Pancreas

Hodson David

Background: The arrangement of beta cells within islets of Langerhans produces a gain-of-function in insulin release through the generation of rhythmic activity patterns. A privileged role for individual beta cells in orchestrating these responses has long-been suspected, but not directly examined.Objective and hypotheses: Identify and characterize a rare subpopulation of beta cells tasked with pacemaking insulin release.Method: Op...

hrp0097s7.1 | Theories of obesity development and their implications on dietary interventions | ESPE2023

Competing Paradigms of Obesity Pathogenesis

Ludwig David

Conventional treatment for obesity, founded on the First Law of Thermodynamics, assumes that all calories are alike, and that to lose weight one must ultimately β€œeat less and move more.” However, this prescription rarely succeeds over the long term. Calorie restriction elicits predictable biological responses – including increased hunger and reduced energy expenditure – that oppose ongoing weight loss. Indeed, the prevailing Energy Balance Model offers ...

hrp0086p2-p273 | Diabetes P2 | ESPE2016

Lower Basal Insulin Dose – Better Control in Type 1 Diabetes

Strich David , Balgor Lucy , Gillis David

Introduction: There is no valid evidenced-based recommendation for the optimum basal insulin dose in type-1 diabetes mellitus when supplied either by continuous subcutaneous insulin infusion (CSII) or multiple daily injections (MDI). We studied this previously by evaluating the dose associated with successful fasting. Another way of looking at this is by evaluating the association between basal insulin dose and HbA1c. To this end we performed a retrospective study of 89 childr...

hrp0082p1-d2-254 | Thyroid (1) | ESPE2014

TSH: Different Normalization Methods, Very Different Normal Upper Limits

Strich David , Karavani Gilad , Gillis David

Background: Distribution of TSH levels is not normal. This is due to physiological changes that cause temporary increases in TSH during physiological events. Several methods are used to normalize the distribution when defining normal limits.Objective and hypotheses: To compare the normal limits defined by three normalization methods vs non-normalized distribution based on a large cohort with no known thyroidal illness.Method: Data ...

hrp0086p2-p839 | Syndromes: Mechanisms and Management P2 | ESPE2016

Evaluation of Referrals for Short Stature to a Regional Paediatric Centre

Yue David , Clarson Cheril

Background: Referrals to pediatric endocrine clinics for short stature are common. Height velocity (HV) is an essential component of the evaluation of short stature as growth deceleration often reflects an underlying pediatric endocrine diagnosis (PED). Access to previous measurements facilitates prompt calculation of HV.Objective and hypotheses: To determine availability of previous measurements at time of referral for short stature, to characterize PED...