hrp0097p1-258 | Fat, Metabolism and Obesity | ESPE2023

An interesting case of combined familial hyperlipidaemia and high lipoprotein (a) in a 20-month-old girl

Karabouta Zacharoula , Simeoforidou Elpida , Georgoulia Konstandina , Koniari Eleni , Bisbinas Alexia , Chrousos George

Introduction: Familial hypercholesterolaemia(FH) is a genetic disorder affecting approximately 1 in 250 people, resulting in high levels of low-density lipoprotein Cholesterol(LDL-C), increasing the likelihood of developing cardiovascular disease(CVD) at a younger age. Lipoprotein (a)(Lp(a)) is another risk factor for atherosclerosis, elevated in 20-25% of people and 90% genetically determined, only slightly reduced by diet, exercise and medication.<p clas...

hrp0097p1-460 | Fat, Metabolism and Obesity | ESPE2023

Improvement of Depressive and Anxiety Symptoms in Children and Adolescents with Overweight and Obesity Following Implementation of a Comprehensive, Multidisciplinary, Personalized, Lifestyle Intervention Program

Vourdoumpa Aikaterini , Paltoglou George , Kassari Penio , Manou Maria , Papadopoulou Marina , Kolaitis Gerasimos , Charmandari Evangelia

Introduction: Childhood obesity is one of the most challenging contemporary public health problems. Children and adolescents with obesity experience multiple psychosocial difficulties, such as low self-esteem, depression, anxiety, and behavioral problems. Psychosocial problems noted in youngsters with excess adiposity persist for a long time. The aim of our study was to assess mental health symptoms in overweight and obese children and adolescents before and a...

hrp0097p1-589 | Thyroid | ESPE2023

Thyrotropin receptor stimulating antibodies in pediatric patients with Graves’ diseases using ultra-rapid turbo bioassay

Bossowski Artur , Hatun Burak , Sawicka Beata , Stożek Karolina , Bossowski Filip , J Kahaly George

Background: Thyrotropin receptor (TSH-R) stimulating autoantibodies (TSAb) are present in 90-100% of patients with Graves’ disease (GD). TSAb are functional, impact thyroid function, and are clinically relevant. This study we performed in a pediatric patients with dynamic of Graves’ disease before and during methimazole therapy and in patient with Hashimoto’s thyroiditis using a novel and ultra-rapid TSAb andTBAb bioassay.<p class="abstex...

hrp0097p2-237 | Diabetes and Insulin | ESPE2023

Genetic evidence for a causal relationship between severe hyperlipidemia and Type 1 Diabetes.

Koniari Eleni , Hatziagapiou Kyriaki , Skouma Anastasia , Chaliotis Fotis , Drosatou Panagiota , Tsani Evelina , Blatsa Vasiliki , Chrousos George

Background: In type 1 diabetes (T1D), the pancreatic βcells are selectively destroyed by the immune system resulting in absolute insulin deficiency. It has been long established that approximately half of the genetic risk for T1D is conferred by genetic loci associated with β-cell function, apoptosis, and regeneration.Aim: We report the case of a 6- year-old boy with new onset type T1D, and identified genetic l...

hrp0098fc12.3 | Thyroid | ESPE2024

Usefulness of application novel TurboTM TSAb bioassay in the monitoring of pediatric Graves’ patients

Bossowski Artur , Sawicka Beata , Borysewicz-Sańczyk Hanna , Bossowski Filip , Kahaly George

Background: Thyrotropin receptor (TSH-R) stimulating autoantibodies (TSAb) are present in 95-99% of patients with Graves’ disease (GD). TSAb are functional, impact thyroid function, and are clinically relevant. This study we performed in pediatric patients with dynamic of Graves’ disease before and during methimazole therapy and in a patient with Hashimoto’s thyroiditis (HT) using a novel and ultra-rapid TSAb bioassay.<...

hrp0098p1-34 | Diabetes and Insulin 2 | ESPE2024

SEXUAL KNOWLEDGE AND CONTRACEPTIVE USE IN ADOLESCENTS WITH TYPE 1 DIABETES IN COMPARISON WITH THEIR HEALTHY PEERS

Paltoglou George , Kandyla Betina , Tsitsika Artemis , Tzavara Chara , Soldatou Alexandra , Karanasios Spyridon , Kossiva Lydia , Karavanaki Kyriaki

Introduction: Adolescents with type 1 diabetes mellitus (T1D) may differ from their healthy peers in respect to sexually transmitted diseases (STDs) knowledge and contraceptive use.Objectives: We aimed to explore sexual knowledge and contraceptive use and associated factors in T1D adolescents compared to healthy peers.Methods: Fifty-eight T1D adolescents (mean&pm;SD age 16.3&pm;2.0...

hrp0098p1-133 | Fat, Metabolism and Obesity 2 | ESPE2024

The effect of a lifestyle intervention program of diet, sleep and exercise on apelin-12, vaspin and resistin concentrations in children and adolescents with overweight and obesity

Karampatsou Sofia-Iliada , Paltoglou George , Genistaridi Sofia-Maria , Kassari Penio , Charmandari Evangelia

Background: Obesity in childhood and adolescence represents one of the most challenging public health problems of the 21st century owing to its epidemic proportions worldwide.Aim: The aim of our study was to determine the concentrations of apelin-12, vaspin and resistin in children and adolescents with overweight and obesity before and 1 year after the implementation of a lifestyle intervention program of diet, sleep and...

hrp0098p2-81 | Diabetes and Insulin | ESPE2024

“Sweet” lies detector; Factitious Diabetes Mellitus as a rare presentation of Munchausen by Proxy syndrome

Paltoglou George , Koutrouli Mina , Panos Alexandros , Plarinou Adamantini , Siori Dimitra , Tzavela Eleni , Soldatou Alexandra , Karavanaki Kyriaki

Background/Purpose: Case report of two siblings (nine-year-old boy and four-year-old girl) with rarely described factitious diabetes by proxy, aim ing to enhance physician’s awareness.Methods: Initially the boy was referred by a physician to the outpatient clinic to apply (successfully) for an insulin pump. The mother convincingly claim ed her son has had T1DM for 3 years. Reported history started during hospitaliz...

hrp0089rfc5.5 | Thyroid | ESPE2018

Evidence for a Founder Effect in Multiple Endocrine Neoplasia 2

Fanis Pavlos , Skordis Nicos , Frangos Savvas , Christopoulos George , Spanou-Aristidou Elena , Andreou Elena , Manoli Panayiotis , Mavrommatis Michalis , Nicolaou Stella , Kleanthous Marina , Cariolou Marios A , Christophidou-Anastasiadou Violetta , Tanteles George A , Phylactou Leonidas A , Neocleous Vassos

Purpose: Multiple Endocrine Neoplasia type 2 (MEN2) affects patients with RET proto-oncogene mutations. This cohort study refer to patients who were diagnosed with familial medullary thyroid carcinoma (MTC) and underwent RET genetic testing in Cyprus between years 2002 and 2017.Methods and Patients: Forty patients underwent RET testing by Sanger sequencing of exons 10–11 and 13–16. Genotyping with STR genetic markers ...

hrp0089rfc6.5 | Fat, Metabolism and Obesity | ESPE2018

High-Throughput Untargeted Plasma Metabolomics Unravels Gender Dimorphic Metabolic Trajectories in Naturally Conceived and ICSI Prepubertal Children

Telonis Aristeidis G , Gkourogianni Alexandra , Papassotiriou Ioannis , Konsta Maria , Papastamataki Maria , Margeli Alexandra , Bartzeliotou Anastasia , Mantzou Emilia , Kosteria Ioanna , Mastorakos George , Loutradis Dimitrios , Chrousos George P , Klapa Maria I , Kanaka-Gantenbein Christina

Background: Accumulating evidence has indicated that assisted reproductive technologies (ART) influence the metabolic physiology of the offspring, with a higher predisposition to metabolic disorders. Long-term metabolomic studies that separately consider males and females conceived with intra-cytoplasmic sperm injection (ICSI) vs naturally conceived (NC) children are needed. Previously, we had reported that ICSI-conceived prepubertal girls exhibit significant alterations in th...