ESPE Abstracts

Background: Mutations in GH-1 gene is a rare cause of isolated growth hormone deficiency. Main features of this condition include markedly reduced secretion of GH combined with low concentrations of IGF-I leading to short stature.Objective and hypotheses: 1.56 years old girl was admitted to our hospital because of short stature. She was born at term from closely related healthy parents. Her birth length and weight were 48 cm (SDS: −1.07) a...

There is not enough reasoned data on the dynamics of body weight indices in premature infants born small by gestational age (SGA).Aim: To study the nutritional status in premature babies born small by gestational age, in the first 5 years of life.Materials and Methods: The prospective study included preterm infant with SGA (n = 100) and prematurity corresponding to gestational age - AGA (n = 69) w...

Aim: to evaluate the frequency and predictors of short stature in preterm infants born small for gestational age (SGA), by the age of 5 years. Materials and Methods. We examined 100 premature babies (gestational age of 22-31 weeks – 18, 32-36 weeks – 82), born SGA with the tables Fenton T. R. et al. (2013). Protocol included an assessment of anthropometric indicators and IGF-1 levels in the blood at birth, at the ages of 1 and 5 years. The odds ratio...

Objectives: The aim of the study was to evaluate the associations of metabolic status and eating behavior (EB) in young children and variants of energy metabolism genes.Materials and Methods: A longitudinal study of 106 children in the dynamics of the first 2 years of life was carried out. Groups of children were identified taking into account BW at birth (large-weight by gestation (n=50), underweight by gestati...

Suitably treatment of Basedow–Graves’ disease (BGD) provide the minimization of time to develop the medicamental remission. Research: determine clinical, laboratory particularities, evaluate efficiency of pharmaceutical treatment of BGD in children in different age groups. Materials and methods: 35 children with BGD were examined (4 boys, 31 girls): 1st group (Tanner 1) n=4, 7.5±0.65 years; 2nd – (Tanner 2–4) n=22, 12.32±0.31 yea...

GHD diagnosis in neonates and infants is a challenge owing to the fact that GH pharmacological stimulation tests (GHST) are not approved at this age. In a retrospective study, we found that a random GH<6.5 µg/L confirmed GHD diagnosis in neonates with clinical suspicion of GHD with high diagnostic accuracy (1). The accuracy of GH and its surrogates of action have not been set for infants with current standardized immunoassays.Objective</...

The survival rate of young patients with cancer has greatly improved in the last decades, in part due to the introduction of new therapeutic agents and protocols.Chemotherapy may be associated with risk of ovarian dysfunction, permanent or transient amenorrhea, symptoms of ovarian insufficiency and infertility.It has been suggested that prepubertal ovary is less susceptible to deleterious effect of chemotherapy.<p class="abstex...

Background/Aims: Magnetic resonance imaging (MRI) is used to investigate the etiology of growth hormone deficiency (GHD). There is a close relationship between structural changes in the pituitary gland and clinical status.We aimed to investigate the relationship between MRI findings and clinical symptoms and treatment response in children with GHD.Methods: The study was conducted in nine Department...

Background/Aims: Magnetic resonance imaging (MRI) is used to investigate the etiology of growth hormone deficiency (GHD). There is a close relationship between structural changes in the pituitary gland and clinical status.We aimed to investigate the relationship between MRI findings and clinical symptoms and treatment response in children with GHD.Methods: The study was conducted in nine Department...

Background: Osteoporosis is a complex disorder, influenced by both environmental and genetic factors. Primary osteoporosis is a rare early onset disorder with high morbidity and mortality. Wnt signaling pathway has been shown to be involved in the regulation of bone remodeling.Case: Native Argentinean boy born from a consanguineous family with history of retinal detachment in the maternal line. Delivered at term, birth weight 2900 g (−0.95 SDS), bi...