ESPE Abstracts

Background: Only a few case reports have described isolated postprandial hyperinsulinaemic hypoglycaemia (PPHH) in children.Objectives: To describe a single tertiary paediatric centre’s experience in the management of isolated PPHH.Patients and methods: Six children (three females) were identified. A retrospective review of the clinical characteristics, diagnosis, management and follow-up of patients with PPHH was performed. I...

Background: Obesity in childhood and adolescence represents a major public health problem of our century and the leading cause of premature cardiovascular disease (CVD). A moderate elevation of thyroid-stimulating hormone (TSH) concentrations is frequently observed in obese children.Aim: The aim of our study was to evaluate the association of TSH and free thyroxine (FT4) concentrations with the clustering of cardiometabo...

Introduction: Pediatric obesity (PO) is associated with hormonal dysfunctions contributing to an increased risk of cardiovascular disease and diabetes. Among these risks, thyroid disfunctions (TD) are the most common. The ethio-pathogenetic mechanisms underlying TD are not well known and include an adaptive response to a higher energy intake, hyperleptinemia, peripheral resistance to thyroid hormones, increased pro-inflammatory cytokines. Pediatric prevalence ...

Introduction: Many evidences confirmed that hyperuricemia is connected with obesity, insulin resistance, type 2 diabetes and cardiovascular risk, not only among adults. Uric acid (UA) interacts with other factors in the modulation of obesity and its complications, since childhood. The study aims to identify any correlations between AU plasma concentrations and the clinical/laboratory data of a group of obese Italian children living in the province of Salerno, ...

Introduction: The role of gamma-glutamyl transferase (GGT) enzyme as a marker of insulin resistance (IR) in pediatric obesity is well known. Recent evidence, mainly in the adult population, has identified GGT/High-Density Lipoprotein (HDL) ratio as a risk index for hepatic steatosis. The study has the purpose of examining the relationship between GGT, GGT/HDL ratio and the clinical/laboratory data of a group of obese Italian children living in the province of ...

Background: The method for assessing adipose tissue thickness using ultrasound has been used extensively in sport medicine. However, the reliability of this method in children was not evaluated. We aim to determine the inter-observer reliability in measuring uncompressed subcutaneous adipose tissue thickness (USAT) using ultrasound, in children.Methods: About 40 healthy children (20 male, 20 female), median age 11.8 years (5.3 to 18.1) were evaluated. Me...

Background: Ring chromosome 18 [r (18)] syndrome belongs to a rare group of chromosomal abnormalities (only about 70 cases reported). The association of r(18) and growth hormone deficiency (GHD) is extremely rare (3 descriptions with different responds to GH treatment). Patients with r(18) syndrome are characterized by short stature, obesity, microcephaly, mental retardation, hypertelorism, epicanthic folds, micrognatia and small hands with short tapering fingers. Also atypica...

Background: Obesity and unfavorable metabolic profile (insulin resistance and/or dyslipidemia) are frequently observed in Polycystic Ovarian Syndrome in Adolescents (PCOS) girls regardless of weight.Objective and hypotheses: To evaluate clinical features and metabolic profile in PCOS adolescents, before, during and after Oral Contraceptive (OC) treatment.Method: We performed a retrospective study on 51 girls with PCOS diagnosed acc...

Background: The development of Cushing’s syndrome from topical corticosteroids in children is rare. It is most often reported in infants after misuse of high potency steroid creams for diaper dermatitis. 0.1% mometasone is a mild-strength topical steroid and so far to our knowledge no Cushing’s syndrome in children after its usage was documented.Objective and hypotheses: The aim was to present a case of iatrogenic Cushing’s syndrome in a 4...

Introduction: Systemic Juvenile Idiopathic Arthritis (sJIA) is an autoinflammatory disease, characterized by the association of arthritis with fever, often accompanied by rash, generalized lymphadenopathy, hepatosplenomegaly, and serositis. The diagnosis requires adequate exclusion of infectious, autoimmune, autoinflammatory, and oncologic diseases. These patients need to be treated with glucocorticoids plus biologic drugs, anti-IL-1 or anti-IL-6 monoclonal an...