hrp0082fc6.1 | Gonads & DSD | ESPE2014

Search for Genetic Defects in the Transcription Factor Genes FOXL2, FOXE1, BMP15, NOBOX, and GDF9 in Children, Adolescents and Young Adults With Premature Ovarian Insufficiency POI

Settas Nikolaos , Anapliotou Margarita , Deligeoroglou Euthimios , Kanavakis Emmanuel , Fryssira Eleni , Kanaka-Gantenbein Christina , Michala Lina , Dacou-Voutetakis Catherine , Creatsas George , Chrousos George P , Voutetakis Antonis

Background: Molecular defects are rarely detected in Premature ovarian insufficiency (POI) patients.Objective and Hypotheses: We hypothesized that the frequency of causative molecular defects could be higher in cases with early onset of POI. Moreover, the analysis of multiple genes in the same POI group could disclose co-existence of more than one molecular aberration.Method: In 25 subjects, aged 17.1±7 years at POI onset, bid...

hrp0082p3-d2-832 | Growth (1) | ESPE2014

The Impact of GH Replacement Therapy in Children Born Small-for-Gestational-Age: growth Response and Safety Profile

Chifu Irina Oana , Bodescu Ioana , Vasiliu Ioana , Idriceanu Jeanina , Fadur Alina , Hreniuc Ana , Ungureanu Maria Christina , Leustean Letitia , Mogos Voichita , Vulpoi Carmen

Background: Children born small-for-gestational-age (SGA) have a birth weight below 2,500 g at a gestational age over 37 weeks or a birth weight or length below the 3-rd percentile for gestational age. They usually recover growth during the first 6–12 months of life, but if not so, it is unlikely the recovery to happen after the age of two unless GH replacement therapy is initiated.Objective: The aim of this study was to evaluate the 1-st year growt...

hrp0082lbp-d3-1017 | (1) | ESPE2014

Exploring the Pathogenesis of Hypothalamic Obesity: the Interaction of Hormonal, Neuronal and Psychological Factors

Steele Caroline , Powell Joanne , Kemp Graham , Halford Jason , Wilding John , Harrold Joanne , Das Kumar , Cuthbertson Daniel , Javadpour Mohsen , MacFarlane Ian , Stancak Andrej , Daousi Christina

Background: Acquired hypothalamic damage frequently causes obesity (BMI ≥30 kg/m2), often refractory to treatment. The interaction of hormonal, neuronal and psychological factors underlying hypothalamic obesity (HO) remains poorly understood.Methods: In fasted and fed states participants underwent blood sampling (GLP-1, insulin, PYY, ghrelin and glucose), fMRI scanning (viewing food/non-food photographs) and assessment of hunger and sati...

hrp0084p1-126 | Thyroid | ESPE2015

Characteristics and Outcome of Neonates with Congenital Hypothyroidism Born After In Vitro Fertilisation

Giogli Vassiliki , Kanaka-Gantenbein Christina , Arditi Jessica-Debora , Platis Dimitris , Chouliaras George , Kourkouti Chrysoula , Kosteria Ioanna , Gika Anna , Iliadi Alexandra , Chrousos George , Girginoudis Panagiotis , Voutetakis Antonis

Background: In vitro fertilisation (IVF) has been widely used during the last decades. Increased susceptibility to birth defects and a higher cardiometabolic risk in children born after IVF than naturally conceived (NC) children have been reported. Also, a higher incidence of hyperthyrotropinemia has been noted in children born after IVF with respect to NC children and has been attributed to an epigenetic modification of the TSH set-point.Object...

hrp0084p2-181 | Adrenals | ESPE2015

Baseline Cortisol Concentrations Predict Positively and Negatively Anti- and Pro- Oxidation, Respectively that are Measured Following an Acute Aerobic Exercise Bout in Pre- and Early Pubertal Normal-Weight and Obese Boys

Paltoglou George , Papagianni Maria , Fatouros Ioannis G. , Mantzou Aimilia , Jamurtas Athanasios , Avloniti Alexandra , Stefanaki Charikleia , Kanaka-Gantenbein Christina , Chrousos George P. , Mastorakos George

Background: Little data exist regarding the hypothalamic-pituitary-adrenal (HPA) axis activation and the interplay between the HPA axis and markers of pro- and anti-oxidation in children, following an acute aerobic exercise bout in children.Objective and hypotheses: To investigate the changes of HPA axis hormones following an acute bout of aerobic exercise and their respective association with markers of pro- and anti- oxidation in normal weight and obes...

hrp0084p3-1254 | Programming & Misc. | ESPE2015

Untargeted Plasma Metabolomics in Prepubertal ICSI and Naturally Conceived Children Unravels Gender: Dimorphic Metabolic Trajectories After ICSI

Gkourogianni Alexandra , Telonis Aristeidis G , Kosteria Ioanna , Margeli Alexandra , Mantzou Emilia , Konsta Maria , Loutradis Dimitrios , Mastorakos George , Papassotiriou Ioannis , Kanaka-Gantenbein Christina , Klapa MariaI , Chrousos George P

Background: ICSI is an assisted reproduction technique (ART) mainly used to overcome male infertility. Nowadays, ICSI is employed frequently due to its high success rate, despite it being highly invasive (i.e. epigenetic risk). Recent studies in ART offspring show a higher incidence of cardio-metabolic risk than in naturally-conceived (NC) controls. Thus, in our prior untargeted metabolomic study between ICSI and NC prepubertal girls, we demonstrated insulin resistance in the ...

hrp0097fc12.4 | Thyroid | ESPE2023

Thyroid hormone resistance due to THRB gene mutations: neonatal manifestations in two cases

Labey Séverine , Savagner Frédérique , Rideau Aline , Sertedaki Amalia , Dolianiti Maria , Sakka Sofia , Siahanidou Sultana , Léger Juliane , Carel Jean-Claude , Kanaka-Gantenbein Christina

Introduction: Thyroid hormone resistance (THR) is a rare disease (≈ 1/50000) mainly due to thyroid hormone receptor beta gene (THRB) mutations, generally identified in late childhood and adulthood. We report 2 atypical cases of neonatal diagnosis of THR.Case 1: The newborn presented with neonatal respiratory distress due to a voluminous compressive goiter, requiring invasive ventilation. Thyroid function test...

hrp0097rfc5.1 | Diabetes and insulin 1 | ESPE2023

Tear proteomics profile in children and adolescents with type 1 diabetes mellitus

Angelopoulou Eleni , Anargyros Vasilakis Ioannis- , Kitani Rosa-Anna , Letsou Konstantina , Lygirou Vasiliki , Zoidakis Jerome , Samiotaki Martina , Kanaka- Gantenbein* Christina , Nicolaides* Nicolas

Background and Purpose: Previous studies have shown differences in serum, plasma, or saliva proteomics profile in patients with type 1 diabetes mellitus (T1DM), compared with healthy controls. The purpose of this prospective study is to identify the tear proteomics profile in children with T1DM that are followed at the Diabetes Center of the First Department of Pediatrics of the National and Kapodistrian University of Athens, at “Aghia Sophia” Chil...

hrp0097p1-103 | GH and IGFs | ESPE2023

Assessing the treatment burden and Quality of Life of children receiving daily recombinant Growth Hormone treatment in Greece

Christoforidis Athanasios , Galli-Tsinopoulou Assimina , Karachaliou Fotini-Eleni , Chrysis Dionisios , Kanaka – Gantenbein Christina , Skiadas Ioannis , Zisimopoulou Oresteia , Poimenidou Apostolia , Windisch Manfred , Sofiaki Nikoletta , Baxevanidi Evangelia , Evelien Gevers

Background: Pediatric growth hormone deficiency (pGHD) is associated with growth attenuation/deceleration, short stature, delayed bone maturation, and metabolic defects. Daily recombinant human growth hormone (rhGH) treatment promotes linear growth and increases growth rate; however, it may present a substantial burden for patients and caregivers. This may lead to low adherence, limiting the clinical effect of treatment. This study assesses the health-related ...

hrp0097p1-152 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

The awakening of the hypothalamic-pituitary-gonadal axis in the post-COVID era; the Greek experience.

Hatziagapiou Kyriaki , Anargyros Vasilakis Ioannis- , Binou Maria , Dolianiti Maria , C. Nicolaides Nicolas , Zoumakis Emmanouil , Papathanasiou Chryssanthi , Gkougkouli Eleni , Barouti Konstantina , Kanaka-Gantenbein Christina , D. Sakka Sophia

Background: Puberty onset results from the interplay between genetic and environmental factors. During COVID-19 pandemic, children experienced epidemic-related changes, such as stress, sedentary lifestyle, excessive use of electronic devices, all leading to weight gain.Objective: The aim of our study is to retrospectively evaluate the incidence of premature activation of the hypothalamic-pituitary-gonadal axis, as eviden...