hrp0092p2-277 | Thyroid | ESPE2019

Congenital Hypothyroidism: Neonatal SCREENING PROGRAM with T4 and TSH

Chueca Maria J. , Moreno Paula , Dura Teodoro , Berrade Sara , Andres Carlos , Garcia Maria Dolores , Moreno Jose Carlos , Ascunce Nieves

Objectives: -To determine children diagnosed with central congenital hypothyroidism (CCH) by a screening program using TSH and total T4 between May 2016 and January 2019.-To analyze the characteristics of the disease in these children.Material and Methods: During the time of the study, 14.743 newborns have been screened. Cut-off points are used for TSH ≥10MU/ml and T4 6 and 20 mg/dl as lower ...

hrp0089p2-p150 | Fat, Metabolism and Obesity P2 | ESPE2018

Brown Adipose Tissue in Prepubertal Children: Associations with Sex and With the Sequence of Prenatal Growth Restraint and Postnatal Catch-up

Malpique Rita , Gallego-Escuredo Jose Miguel , Sebastiani Giorgia , Villarroya Joan , Lopez-Bermejo Abel , de Zegher Francis , Villarroya Francesc , Ibanez Lourdes

Background/objectives: Individuals born small-for-gestational age (SGA), especially those who experience postnatal catch-up growth, are at increased risk for developing endocrine-metabolic abnormalities before puberty. In adults, brown adipose tissue (BAT) has been associated with protection against metabolic disorders, such as obesity, type 2 diabetes and dyslipidaemia. Here, we assessed for the first time whether BAT activation differs between prepubertal children born SGA o...

hrp0086p2-p398 | Gonads & DSD P2 | ESPE2016

Nonclassic Congenital Adrenal Hyperplasia and Functional Ovarian Hyperandrogenism Diagnosed During the Transition Period: Differences in Clinical, Hormonal and Metabolic Aspects

Boquete Hugo , Azaretzky Miriam , Llano Miriam , Jose Iparraguirre Maria , Schwartz Nadia , Suarez Martha , Boquete Carla , Sobrado Patricia , Fideleff Hugo

Introduction: Hyperandrogenism is a common presenting complaint during the transition period; however, clinical, hormonal and metabolic parameters in these patients have not been yet adequately characterized.Objective: To evaluate the disease-related history, clinical presentation and biochemical parameters in patients diagnosed during this period with nonclassic congenital adrenal hyperplasia (NCCAH) due to 21α hydroxylase deficiency and patients w...

hrp0086p1-p903 | Thyroid P1 | ESPE2016

HABP2 as Genetic Susceptibility Factor for Familial Differentiated Thyroid Carcinoma

de Randamie Rajdee , Martos Gabriel , Lumbreras Cesar , Regojo Rita Maria , Mendiola Marta , Argente Jesus , Moreno Jose Carlos

Background: HABP2 is an extra-cellular matrix protein involved in cell proliferation. Recently, HABP2 was proposed as responsible for the familial clustering of Differentiated Thyroid Carcinoma (FDTC). However, its involvement was questioned by subsequent studies revealing high prevalence HAPB2 polymorphisms (SNPs) in the general population, leaving its pathogenic role uncertain.Objective and hypotheses: To identify genetic HABP2</e...

hrp0086p1-p909 | Thyroid P1 | ESPE2016

Identification of a “Cryptic” De Novo Deletion in NKX2.1 in the Brain-Lung-Thyroid Syndrome using Genomic SNP Arrays

Villafuerte Beatriz , de Benito Daniel Natera , Lacamara Nerea , Garcia Marta , Lumbreras Cesar , de Randamie Rajdee , Nevado Julian , Moreno Jose Carlos

Background: Genetic defects in NKX2.1 (chromosome 14q13) are associated with hypothyroidism, choreo-athetotic movements and respiratory distress, known as the “Brain-Lung-Thyroid syndrome”.Objective and hypotheses: To identify the genetic basis of a disorder compatible with the “NKX2.1 syndrome” and extra features outside the typical triad.Patients and methods: 10-year old girl with congenital ...

hrp0082p1-d1-179 | Perinatal and Neonatal Endocrinology | ESPE2014

Variations in Protein Expression in Small-For-Gestational-Age Newborns

Ruiz-Gonzalez Maria Dolores , Canete Maria Dolores , Gomez-Chaparro Jose Luis , Lopez-Barea Juan Luis , Canete Ramon

Introduction: Small-for-gestionational-age newborns (SGA-NB) may present subsequent comorbidities affecting their metabolism, growth, and development. Analysis of changes in serum proteome profile expression in SGA-NB may provide physiopathological information and help to identify postnatal biomarkers.Aim: To compare serum proteome profiles in SGA vs AGA newborns, stratified by gestational age.Study population and method: The study...

hrp0084p1-107 | Perinatal | ESPE2015

Changes in Serum Protein Expression in Small-for-Gestational-Age Newborn Infants at Different Gestational Ages

Canete Ramon , Ruiz-Gonzalez Maria Dolores , Canete Maria Dolores , Gomez-Chaparro Jose Luis , Abril-Diaz Nieves , Lopez-Barea Juan Luis

Background: Small-for-gestational-age (SGA) newborn infants (NB) may present long-term comorbidities influencing their metabolism, growth and/or development. Although their serum proteome is unknown, altered expression of the proteome profile may provide information on their physiopathology and lead to the discovery of biomarkers for postnatal complications.Aim: To detect changes in the serum proteome in SGA-NB vs adequate-for-gestational-age (AGA) newbo...

hrp0094p2-115 | Diabetes and insulin | ESPE2021

HbA1c and Glucose Management Indicator relationship: can HbA1c determination be avoided?

Navarro Moreno Constanza , Sanchez Ruiz Daniel , Jose Garcia Garcia Emilio , Elizagarate Izaskun Marchueta , Gomez Gila Ana Lucia ,

Introduction: Continuous Glucose Monitoring (CGM) devices have introduced new metrics to assess metabolic situation of patients with type 1 diabetes mellitus (T1DM). Among them, the glucose management indicator (GMI) provides a proxy to HbA1c, however, these measures do not always match.Purposes: To evaluate the concordance between GMI and HbA1c, and determinate in which scenarios GMI could replace HbA1c.Subjects a...

hrp0094p2-120 | Diabetes and insulin | ESPE2021

Effect of metabolic control on the presence of Nonalcoholic Fatty Liver Disease (NAFLD) in adolescents with type 2 Diabetes.

Orozco Morales Jose Antonio , Torres Tamayo Margarita , Suarez Pilar Dies , Urrutia Aida Medina , Bravo Patricia Guadalupe Medina ,

Background: Type 2 diabetes (T2D) is an emerging disease in the pediatric population. The association between T2D and non-alcoholic fatty liver disease (NAFLD) has been described; the mechanisms responsible for the development and progression of NAFLD are incompletely understood. Evidence of high Haemoglobin A1c (HbA1c) levels and the risk of diabetes complications has been demostrated. Recent evidence suggests that metabolic control may have a role in the dev...

hrp0094p2-204 | Fat, metabolism and obesity | ESPE2021

Changes in objectively measured physical activity after 2-year lifestyle intervention in pediatric patients with abdominal obesity

Ojeda-Rodriguez Ana , Morell-Azanza Lydia , Luis Leon Jose , Macias Maria , Chueca Maria , Marti Amelia , Cristina Azcona-Sanjulian Maria ,

Introduction: it has been widely demonstrated that high physical activity (PA) levels prevent obesity development. The practice of moderate, regular PA reduces abdominal obesity, hypertension, insulin resistance, dyslipidemia and improves risk factors for obesity-related comorbidities (e.g. diabetes or cardiovascular diseases) independently of weight loss. However, in the childhood population, where sedentary behavior has increased in recent decades, few studi...