hrp0097p1-58 | Fat, Metabolism and Obesity | ESPE2023

Neck circumference and metabolic score before and after long-term impact of a lifestyle intervention in patients with abdominal obesity

Azcona-Sanjulian Cristina , Ana Catalan , Ana Ojeda-Rodriguez , Chueca María , Sara Berrade , Marti Amelia

Aim: to assess and follow-up neck circumference and its relationship with a metabolic score in patients with abdominal obesity after a lifestyle intervention.Patients, Material and Methods: 122 children and adolescents with abdominal obesity, aged 7 to 16 years, were included in a control randomized intervention study (NCT031472). Abdominal obesity was diagnosed using the waist circumference. The intervention included an...

hrp0097p2-33 | Fat, Metabolism and Obesity | ESPE2023

Obesity-related Hypothyroidism in Children

Otilia Bizerea-Moga Teofana , Olah Orsolya , Ilieș Cristina , Flavia Brad Giorgiana , Mărginean Otilia

Key Words: obesity, subclinical hypothyroidism, childrenIntroduction: There is a growing interest in the relationship between obesity and thyroid dysfunction, even more so nowadays when obesity has become a widespread global issue. Initially believed to be the cause of obesity, the risk of developing hypothyroidism may be increased in obese children due to adaptive mechanisms. The study aims to evaluate the prevalence of...

hrp0097p2-75 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Foetal exposures to endocrine-disrupting chemicals. INMA-ASTURIAS COHORT. SPAIN.

Cristina Rodríguez-Dehli Ana , Fernández-Somoano Ana , Riaño Galán Isolina , Tardon Adonina

Background: Endocrine-disrupting chemicals (EDCs) are serious and urgent threats to public health, due to the potentially serious adverse effects of EDCs on endocrine processes during susceptible periods of human development.Objective: To evaluate the levels endocrine disruptors at gestation.Material and methods: A pilot study. Data were obtained from 30 pregnant mothers recruited ...

hrp0097p2-295 | Late Breaking | ESPE2023

Metabolic and growth outcome of two-years growth hormone treatment in children born small for gestational age: a retrospective study

Ferrigno Rosario , Cristina Savanelli Maria , Cioffi Daniela , Pellino Valeria , Klain Antonella

Children born small for gestational age (SGA) not showing catch-up growth in the first two years of life may show decreased growth rate and adult height, as well as worse metabolic profile, compared to general population. In these patients, growth hormone (GH) treatment is recommended, showing positive effects on both growth rate and metabolic profile, with good tolerability. The aim of the current study was to evaluate the auxological and metabolic effects and the safety of G...

hrp0097p2-303 | Late Breaking | ESPE2023

The link between birthweight, obesity and insulin resistance

Olah Orsolya , Ilies Cristina , Atamni Samah , Marginean Otilia , Bizerea-Moga Teofana-Otilia

Background: Childhood obesity has emerged as a global pandemic, posing significant health challenges and necessitating urgent action to address its widespread prevalence and associated metabolic consequences. Understanding the link between childhood obesity, being born large for gestational age (LGA), and insulin resistance (IR) in children is crucial for developing targeted interventions and sustainable preventive measures against long-term health risks assoc...

hrp0097p2-304 | Late Breaking | ESPE2023

Metabolic syndrome in overweight and obese children

Ilies Cristina , Olah Orsolya , Fayad Almohamed , Marginean Otilia , Bizerea-Moga Teofana-Otilia

Introduction: Metabolic syndrome (MetS) is a group of conditions that occur simultaneously, involving excess body fat, arterial hypertension, impaired glucose metabolism and dyslipidemia. Establishing effective preventive measures and therapies requires an understanding of the relationship between childhood obesity and the early development of MetS components.Objective: The aim of this study was to identify and explore t...

hrp0098p1-235 | Fat, Metabolism and Obesity 4 | ESPE2024

Towards a “Genetic Obesity Risk Score”: preliminary data from a single-centre cohort of obese children and adolescents

Partenope Cristina , Monteleone Giorgia , Rovellotti Matteo , Petri Antonella , Prodam Flavia , Bellone Simonetta , Rabbone Ivana

Background: Genetic factors play an important role in determining individual susceptibility to weight gain and obesity. In the last few years, several genetic variants have been identified as causative of monogenic/syndromic forms of obesity, mainly involved in the hypothalamic leptin-melanocortin pathways (LMP) that regulates food intake and energy homeostasis.Methods: Pediatric patients (<18 years) with severe obesi...

hrp0098p3-122 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2024

Challenging management of an extreme preterm neonate with persistent hypoparathyroidism

Partenope Cristina , Capra Eleonora , Binotti Marco , Giraudo Isaac , Petri Antonella , Rabbone Ivana , Prodam Flavia , Bellone Simonetta

Background: Symptoms of hypocalcaemia in neonates are nonspecific, including irritability, fine tremors and seizures or sudden death due to arrhythmias. Transient hypoparathyroidism is common in the first days of life in preterm infants. Permanent hypoparathyroidism is primarily due to genetic or autoimmune factors, with post-surgery or infiltration-related forms being rare in pediatrics.Case Presentation: A baby was bor...

hrp0098p3-226 | Pituitary, Neuroendocrinology and Puberty | ESPE2024

Evaluation of service provision for patients with Precocious Puberty in a District General Hospital

Louca Christina , Mejeha Ijeoma , Cox Karen , Jain Gunjan , Jones Stephanie , Matei Cristina

Background: There has been a secular increase in Precocious puberty in recent years. We have also seen an increase in referrals and confirmed cases of precocious puberty in our clinics. The suspected cased underwent a Gonadotrophin Releasing Hormone (GnRH) test (GnRH) The initiation of therapy is discussed with tertiary endocrinologist colleagues, but the treatment has been delivered locally. We have recently discussed with colleagues from pharmacy aspects rel...

hrp0098p3-267 | Thyroid | ESPE2024

Unraveling Refetoff Syndrome: Insights from a Pediatric Endocrinology Case

Del GiaccoLuisa , Tarantola Giulia , VincenziGaia , Campi Irene , AbbateMarco , Barera Graziano , Persani Luca , Cristina VigoneMaria

A was born at 38+4 weeks by eutocic delivery, with adequate auxological parameters and unremarkable perinatal history. She was admitted to our center at 15 days of life after the second screening for congenital hypothyroidism (CH) resulted positive (bTSH 48 mU/L); the first test was negative. Serum blood tests confirmed the diagnosis of CH (TSH 157 mU/L, FT4 0.96 ng/dl, FT3 8.44 pg/ml, negative thyroid autoimmunity). Thyroid ultrasound showed a gland of normal size. Therefore,...