hrp0097fc5.1 | Diabetes and insulin 1 | ESPE2023

Diabetes mellitus and gender incongruence: Worse metabolic control in type 1 and higher mental health issue rates in type 1 and 2 diabetes – a DPV registry study

Boettcher Claudia , R. Tittel Sascha , Reschke Felix , Fritsch Maria , Schreiner Felix , Achenbach Maike , Thiele-Schmitz Susanne , Gillessen Anton , Nellen-Hellmuth Nicole , Golembowski Sveb , W. Holl Reinhard

Background: The condition when a person’s gender identity does not match the gender assigned at birth is called gender incongruence (GI). GI numbers increased tremendously over the last decade. Diabetes mellitus – type 1 and type 2 – is a severe and lifelong disease. GI combined with diabetes may potentiate the burden for affected people.Objective: The study aimed to characterize people with GI and diab...

hrp0097fc7.4 | Sex differentiation, gonads and gynaecology or sex endocrinology | ESPE2023

The effect of common genetic variants in CYP19A1 on serum Estradiol to Testosterone Ratio in healthy Danish children and adolescents

L. R. Groendahl Veronica , A. Holmboe Stine , S. Busch Alexander , Aksglaede Lise , P. Hagen Casper , H. Johannsen Trine , H. Petersen Jørgen , Almstrup Kristian , Frederiksen Hanne , Juul Anders

Background and Aim: Despite the broad individual variation of pubertal maturation, references traditionally describe growth in relation to just chronological age and not biological age. Hence, growth references for the adolescent period have been of limited usefulness for monitoring individual growth in clinic and for research. Especially for children and adolescents with chronic diseases is there a need to better evaluate if changes in SD-scores just before a...

hrp0097p1-554 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

The Evaluation of Cranial Magnetic Resonance Images of Rapidly Progressive Early Puberty Cases

Kilinç Uğurlu Aylin , Özdem&idot;r Gökçe Ayse , Çakir Gündoğan Seçil , Seçil EkşİOğlu Ayşe , Boyraz

Mehmet

Purpose: We aimed to determine the frequency and distribution of intracranial pathologies in patients over 8 years of age by evaluating MRI images of patients diagnosed with early puberty-rapidly progressive.Materials and Methods: The study comprised 118 female patients diagnosed with precocious puberty (PP) and rapidly progressive early puberty (RPEP). The onset of puberty in girls before the age of 8 years is defined a...

hrp0097p1-189 | Thyroid | ESPE2023

Anemia-based Screening for Resistance to Thyroid Hormone Alpha in Children

Akın Kağızmanlı Gözde , Kırbıyık Özgür , Abacı Ayhan , Böber Ece , Yiş Uluç , Demir Korcan

Background: Resistance to thyroid hormone alpha (RTH-α) is characterized by varying degrees of symptoms and findings related to hypothyroidism. However, diagnosis is difficult since thyroid-stimulating hormone (TSH) levels are normal. Free triiodothyronine (fT3) and free thyroxine (fT4) levels can also be normal, but normo- or macrocytic anemia is generally present in the reported cases. L-thyroxine can alleviate some symptoms; however, there is limited ...

hrp0097p1-595 | Thyroid | ESPE2023

A Case report of papillary thyroid carcinoma diagnosed at an early age

Aydın Behram Bilge , Donbaloğlu Zeynep , Barsal Çetiner Ebru , Singin Berna , Karagüzel Güngör , Ünver Tuhan Hale , Parlak Mesut

Introduct&idot;on: Thyroid cancers are rare malignancies in childhood and their incidence is between 1.5-3% among all childhood cancers. Papillary thyroid cancer (PTC) constitutes more than 90% of childhood thyroid cancers. Risk factors for thyroid cancer include; There are iodine deficiency, radiation exposure, radiotherapy to the head and neck region, and genetic predisposition. We will present an 8-year-old case who presented with a complaint of neck swelli...

hrp0097p2-25 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Coexistence of Pituitary Stalk Interruption Syndrome, Sacrococcygeal Teratoma and Horseshoe Kidney

ÖzdemİR Uslu Zülal , Akin Agah , Tuğçe Tunca Küçükal&idot; Elif , Muratoğlu Şah&idot;n Nursel , Çet&idot;nkaya Semra

Introduction: Pituitary stalk interruption syndrome is a rare congenital abnormality of the pituitary gland manifesting with varying degree of anterior pituitary insufficiency. It is presented with isolated growth hormone deficiency or multiple anterior pituitary hormone deficiencies. It is characterized by the triad of thin or interrupted pituitary stalk, hypoplasia or aplasia of adenohypophysis and ectopic or absent neurohypophysis. It is manifested with hyp...

hrp0097p2-97 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2023

Single Center Experience in Patients with Mixed Gonadal Dysgenesis

Barsal Çetiner Ebru , Donbaloğlu Zeynep , Singin Berna , Aydın Behram Bilge , Karagüzel Güngör , Tuhan Hale , Parlak Mesut

Objective: Mixed gonadal dysgenesis (MGD) (45,X,46,XY mosaicism) is a rare chromosomal disorders of sexual development (DSD). In this article, single center data were evaluated.Material Method: From the files of ten patients followed up with the diagnosis of mixed gonadal dysgenesis, complaints and physical examination findings, laboratory tests, chromosome analysis, FISH results, ultrasound, laparoscopy, pathology repor...

hrp0082lbp-d3-1011 | (1) | ESPE2014

The Circulating miRNAs Expression in Simple Obese Children

Liang Liyang , Meng Zhe , Liu Zulin , Hou Lele , Zhang Lina , Lao Wenqin

Background: Childhood obesity is a major health concern worldwide which is associated with increased risk of chronic diseases such as metabolic syndrome (MS). MicroRNAs have been showed to play regulatory roles in several biological progresses such as adipocyte differentiation, glucose and lipid metabolism and insulin signaling pathway. The studies of the circulating miRNAs expressing involved in obesity and MS are of essential importance as it could lead to the identification...

hrp0095fc5.1 | Adrenals and HPA Axis | ESPE2022

Transcriptome profiling of adrenocortical tumors from children with unfavorable disease presentation.

Bueno Ana C , da Silva Jr Rui M P , Stecchini Mônica F , Cardinalli Izilda A , Junqueira Thais , A Scrideli Carlos , AF Molina Carlos , Tucci Silvio , Coeli-Lacchini Fernanda B , Moreira Ayrton C , Ramalho Leandra NZ , Brandalise Silvia R , Yunes José A , Vêncio Ricardo ZN , de Castro Margaret , Antonini Sonir R

Children diagnosed with adrenocortical tumors (ACT) have variable prognosis depending on disease presentation at diagnosis. Available therapeutic options render excellent outcome for a subset of patients, but limited improvement in the survival of those diagnosed with non-localized/advanced disease. ACT DNA methylation was recently demonstrated to be a robust and independent prognostic biomarker. Aiming to identify potential therapeutic targets for these children, we compared ...

hrp0095p1-392 | Thyroid | ESPE2022

Clinical Features, Risk Classifications and Long-Term Follow Up Of Childhood Differentiated Thyroid Cancer(DTC): A Single Reference-Center Experience

Aycan Zehra , Çetin Sirmen Kızılcan , Zeynep Şıklar , Elif Özsu , Fitöz Suat , Ceyhan Koray , Yağmurlu Aydın , Göllü Bahadır Gülnur , Ünal Emel , Taşyıldız Nurdan , Kır Metin , Soydal Çiğdem , Berberoğlu Merih

Background: Thyroid cancers are rare in childhood. ATA guideline (Pediatric section) has been applied in daily practice since 2015. It is very significant to accurately predict the risk in the management of differentiated thyroid cancer(DTC). For this purpose, we shared our single center-20-year-experience about the follow-up features and management of childhood and adolescent thyroid cancer. We aimed to evaluate the dynamic risk stratification (DRS) and the o...