hrp0098p1-207 | Thyroid 2 | ESPE2024

Newborn screening for congenital hypothyroidism and re-screening at two weeks of life in infants born to mothers with thyroid diseases.

Vincenzi Gaia , Cristina Vigone Maria , Cavarzere Paolo , Palma Lorella , Camilot Marta , Teofoli Francesca , Amicosante Riccardo , Rotondi Daniela , Cereda Cristina , Cappelletti Laura , Alberti Luisella , Barera Graziano , De Angelis Simona , Olivieri Antonella

Background: The benefit of re-screening at 15 days of life in infants born to mothers with thyroid diseases (TD+) is a debated issue. In Italy, all the 16 newborn screening (NBS) laboratories use TSH measurement on dried blood spot as primary screening test for primary congenital hypothyroidism (CH) and adopt a 2-screen strategy in special categories of infants at risk of delayed TSH rise (preterm birth, admission to NICU, extra-thyroidal malformations, twinni...

hrp0095p1-224 | Bone, Growth Plate and Mineral Metabolism | ESPE2022

High Vitamin Deficiency Throughout Childhood. Inma-Asturias Cohort. Spain

Rodríguez-Dehli Cristina , Fernández-Somoano Ana , Riaño-Galán Isolina , Venta Rafael , Tardon Adonina

Background: Vitamin D (25OHD) insufficiency is becoming a public health issue. Adequate 25OHD status during pregnancy may influence the health status of the offspring.Objective: To evaluate the levels of 25OHD from gestation to 12 years, assessing seasonality and intake.Material and methods: Data were obtained from 485 pregnant mothers recruited in Asturias between 2004-2007 and th...

hrp0095p1-61 | Diabetes and Insulin | ESPE2022

Increased incidence of childhood type 1 diabetes during COVID-19 pandemic. Figures from an Italian tertiary care center

Deodati Annalisa , Rapini Novella , Pampanini Valentina , Ciampalini Paolo , Cristina Matteoli Maria , Patriza Patera Ippolita , Schiaffini Riccardo , Stefano Cianfarani

Background: CDC (Centers for Disease Control and Prevention) reported an increased risk of newly diagnosed diabetes over 30 days after SARS-CoV-2 infection among persons aged < 18 years. Similarly, the results from the DPV Registry demonstrated a significant increase in the incidence of pediatric Type 1 Diabetes during COVID-19 pandemic. The underlying mechanisms are not yet elucidated.Aim: To investigate the incidenc...

hrp0095p1-468 | Fat, Metabolism and Obesity | ESPE2022

Long term impact of a lifestyle intervention on anthropometry and biochemical parameters in patients with abdominal obesity

Cristina Azcona-Sanjulian Maria , Catalán Ana , Ojeda-Rodriguez Ana , Gea Alfredo , Chueca María , Berrade Sara , Marti Amelia

Aim: to assess and follow-up anthropometric and biochemical parameters in patients with abdominal obesity after a lifestyle intervention.Patients, Material and Methods: 122 children and adolescents with abdominal obesity, aged 7 to 16 years, were included in a control randomized intervention study (NCT031472). Abdominal obesity was diagnosed using the waist circumference. The intervention included an intensive phase duri...

hrp0095p2-250 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2022

Clinical case: Diagnostic / therapeutic procedure of a 46,XY complete gonadal dysgenesis.

Balsamo Antonio , Baronio Federico , Wischmeijer Anita , Menabò Soara , Cristina Meriggiola Maria , Schwienbacher Christine , Di Natale Valeria , Cassio Alessandra

The proband is a Caucasian girl with primary amenorrhea and no breast development at the age of 16 11/12 yrs. Unrelated parents; an older brother in good health and a twin brother (GA 31 days; BW 1450g) with reported agenesis of the corpus callosum and socio-emotional behavioral problems. The mother (menarche 14 yrs. and bicornuate uterus) presented four early spontaneous abortions and one stillborn fetus (46, XX) in the 6th month of pregnancy; remaining negative family histor...

hrp0092fc7.3 | Diabetes and Insulin Session 2 | ESPE2019

MicroRNA Circulating Levels in Children at Diagnosis of Type 1 Diabetes

Inzaghi Elena , Rapini Novella , Deodati Annalisa , Schiaffini Riccardo , Patera Patrizia , Matteoli Maria Cristina , Ciampalini Paolo , Cianfarani Stefano

Background: Type 1 diabetes (T1D) is a chronic disease characterized by autoimmune destruction of pancreatic beta-cells. Dysregulated miRNA levels have been described in T1D patients, though results are inconclusive.Objective and Hypotheses: The aim of this study was to assess the circulating profile of different miRNAs in children at diagnosis of T1D.Method: 27 children with T1D o...

hrp0092p2-102 | Diabetes and Insulin | ESPE2019

Flash Glucose Monitoring System Versus Blood Sugar Test Strips: Cost Comparison and Satisfaction During a Year in a Northern Spain Region

Bertholt Zuber Maria Laura , Freijo Martin Concepción , Naranjo Gonzalez Cristina , Palenzuela Revuelta Inmaculada , Mariscal Sara Pozas

Background: The flash glucose monitoring system (FGMS) has been a great advance in quality of life for patients diagnosed with type 1 diabetes (T1D). However, it is a more expensive method.Objectives: To describe the characteristics of the pediatric population (<18 years) diagnosed with T1D using FGMS, during one year in our community. To assess the degree of satisfaction and possible inconveniences. To evaluate the ...

hrp0092p2-298 | Thyroid | ESPE2019

Neonatal Hyperthyroidism: Our Centre's Experience

Vigone Maria Cristina , Vincenzi Gaia , Caiulo Silvana , Di Frenna Marianna , Saracco Luca , Cecchetti Valeria , Mosca Fabio , Barera Graziano , Weber Giovanna

Objective: Neonatal hyperthyroidism is a severe but generally transient condition with a 2% prevalence in offspring of mothers affected by Graves' disease. It is caused by the transplacental passage of maternal anti-thyrotropin receptor stimulant antibodies (TRABs). Here we report the cases diagnosed at our centre between 2015-2019 in order to re-evaluate the diagnostic and therapeutic approach to this challenging neonatal thyroid alteration.<p cla...

hrp0089p1-p073 | Diabetes &amp; Insulin P1 | ESPE2018

Efficacy of Real-time Continuous Glucose Monitoring in Type 1 Diabetic Pre-school and School Children Treated with Multiple Daily Injections

Schiaffini Riccardo , Rapini Novella , Pellicano Grazia , Patera Patrizia Ippolita , Ciampalini Paolo , Matteoli Maria Cristina , Deodati Annalisa , Cianfarani Stefano

Background: Young children affected by Type 1 Diabetes (T1D) are prone to glucose fluctuations and hardly reach a stable glycometabolic control, especially when treated with a Multiple Daily Insulin Injections (MDI) scheme. The recent Real-Time Continuous Glucose Monitoring (RT-CGM) System, Dexcom G5, the only available device registered for non-adjunctive insulin intervention, potentially facilitates a better management of the disease. Evidence regarding CGM effectiveness amo...

hrp0089p1-p135 | Fetal, Neonatal Endocrinology and Metabolism P1 | ESPE2018

Cardiac and Vascular Assessments in Small- vs Appropriate-for-Gestational-Age Infants at Ages 1 and 2 Years

Garcia-Beltran Cristina , Sebastiani Giorgia , Pie Stella , Guerra Alberto , Lopez-Bermejo Abel , de Zegher Francis , Roses Ferran , Ibanez Lourdes

Background: Children born small-for-gestational age (SGA), especially those who experience spontaneous postnatal catch-up growth, are at increased risk for developing insulin resistance, central adiposity and cardiovascular abnormalities later in life. By age 3-6 years, SGA children have a broader aortic and carotid intima media thickness (aIMT and cIMT) which are markers of preclinical atherosclerosis.Objective: To assess longitudinally – at age 12...