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hrp0097p1-449 | Fat, Metabolism and Obesity | ESPE2023

Body composition following initiation of daily glucocorticoid in Duchenne Muscular Dystrophy: Identifying the timing of increase of fat mass to introduce intensive weight management strategies

McQuillan Erin , Dunne Jennifer , Mochrie Rachel , Horrocks Iain , Joseph Shuko , Choong Wong Sze

Background: Glucocorticoid (GC) therapy is standard of care of management of Duchenne Muscular Dystrophy (DMD) but its use is associated with a range of side-effects. Weight gain leading to significant obesity is common in GC treated boys. There are limited studies evaluating body composition in DMD following initiation of GC, and the timing of increase in fat mass is not known.Aim(s): To evaluate changes in growth param...

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hrp0086p1-p546 | Perinatal Endocrinology P1 | ESPE2016

Higher Risk of Low Birth Weight and Multiple Nutritional Deficiencies in Neonates from Mothers after Gastric Bypass: A Case Control Study

Gerard Maxime , Gascoin Geraldine , Salle Agnes , Frein Dorothee , Topart Philippe , Becouarn Guillaume , Schmitt Francoise , Briet Claire , Rouleau Stephanie , Sentilhes Loic , Coutant Regis

Background: Maternal bariatric surgery is associated with increased risk of small-for-gestational-age infants. Risk of nutritional deficiencies in neonates of mothers with prior gastric bypass (GBP) is unclear.Methods: This study compared the clinical and cord blood biological characteristics of 56 newborns of GBP mothers and 56 newborns of healthy mothers, in the Obstetrics Department of Angers University Hospital between 01/03/2008 and 31/10/2012. Afte...

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hrp0094p1-139 | Growth Hormone and IGFs A | ESPE2021

The effect of growth hormone therapy on linear growth and weight gain in children with growth hormone deficiency vs idiopathic short stature (ISS) a controlled study

Elsiddig Sohair , Soliman Ashraf , Alaaraj Nada , Khalil Ahmed , Ahmed Hannah ,

Introduction: Controversy still exists about the effect of GH treatment on linear growth and weight gain (WG) in children with ISS.Aim: To study linear growth and weight gain in children with ISS treated with GH vs those not treated in comparison with treated children with GHD.Methodology: We conducted a longitudinal controlled study on 78 children presented to a pediatric clinic with short stature...

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hrp0094fc2.3 | Fat, Metabolism and Obesity | ESPE2021

A Phase 2 Trial of the Melanocortin-4 Receptor Agonist Setmelanotide in Obesity Due to SRC1 Insufficiency: Body Weight, Body Mass Index Z Score, and Safety Results

Farooqi Sadaf , Argente Jesus , Martos-Moreno Gabriel , Oral Elif , Spiliotis Bessie , Kostopoulou Eirini , Pinhas-Hamiel Orit , Ben-Ami Michal , Ohayon Olga , Scimia Cecilia , Yuan Guojun , Stewart Murray , McCormack Shana ,

Background: Rare genetic diseases of obesity can be caused by genetic variants leading to disrupted activity of the melanocortin-4 receptor pathway (MC4R). Setmelanotide, an MC4R agonist, is being investigated in a basket study of populations with rare variants in different genes in the MC4R pathway who have early-onset, severe obesity and hyperphagia.Methods: This ongoing, Phase 2, open-label study (NCT03013543) enrolle...

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hrp0094pl7 | Novel insights into weight regulation | ESPE2021

Novel insights into weight regulation

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hrp0095rfc1.5 | Thyroid | ESPE2022

“Screening for congenital hypothyroidism in preterm newborns: Thyroid Stimulating Hormone (TSH) percentiles for weight and gestational age and congenital hypothyroidism features”

Gerdi Tuli , Jessica Munarin , Kristela Topalli , Daniele Tessaris , Patrizia Matarazzo , Luisa De Sanctis

Background: Preterm newborns (PN) are at risk of developing congenital hypothyroidism (CH) with a high reported incidence (1:300 vs 1:2000 for at term newborns). The study's objective was to determine the TSH percentiles at neonatal screening (NS) in PN and to analyze the incidence of permanent and transient CH in this population.Materials and Methods: PN born in the Piedmont Region of Italy in the period 2019-2021 ...

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hrp0089p1-p115 | Fat, Metabolism and Obesity P1 | ESPE2018

Greater Maternal BMI Early in Pregnancy and Excessive Gestational Weight Gain are Independently Associated with Adverse Health Outcomes in the Offspring at Age 7 Years

Derraik Jose G B , Chiavaroli Valentina , A Hopkins Sarah , Biggs Janene B , Rodrigues Raquel O , Seneviratne Sumudu N , McCowan Lesley M E , Cutfield Wayne S , Hofman Paul L

Background: Maternal overweight/obesity during pregnancy and excessive gestational weight gain (GWtG) have been recognized as important early-life risk factors for childhood obesity. We aimed to examine whether maternal BMI at 20 weeks of gestation and excessive GWtG were associated with alterations in body composition and metabolism in childhood in the offspring of primiparous mothers who participated in a randomised controlled trial of exercise regimen during pregnancy.<...

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hrp0082p2-d1-362 | Fat Metabolism & Obesity | ESPE2014

Age at Onset of Weight Gain in Prader–Willi Syndrome is Often Between 1 and 2 Years, Preceding the Hyperphagic Phase; Implications for Management

Donaldson Malcolm , Hammed Noran Abu-Of , Shaikh M Guftar

Background: PraderWilli syndrome (PWS) results from loss of paternally imprinted genes from the 15q1113 region and causes hypotonia with weight faltering in infancy, followed later by obesity which is classically attributed to hyperphagia.Objective and hypotheses: To determine, where possible, the age at onset of unwanted weight gain (as opposed to actual obesity) in children with PWS attending a specialist clinic.Metho...

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hrp0097p1-83 | Fat, Metabolism and Obesity | ESPE2023

Improvement in Health-Related Quality of Life scores in Children and Young people with Obesity following intervention and support from a Tertiary MDT Weight Management Service

Ramya Gokul Pon , Apperley Louise , Parkinson Jennifer , Clarke Ellie , Gubaeva Diliara , Clark Kate , Lund Kim , Owens Meghan , Senniappan Senthil

Introduction: Obesity is a significant public health concern affecting children and young people (CYP) worldwide. The impact of obesity on CYP is multi-faceted and can have a significant effect on their lives. They are at risk of being stigmatized and discriminated against, leading to poor academic performance and social functioning. It is crucial to assess the impact of obesity on the lives of CYP through tools such as Health-related quality of life (HRQOL) q...

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hrp0092p1-381 | Growth and Syndromes (to include Turner Syndrome) (2) | ESPE2019

The Relation Between Changes in Body Mass Index (BMI) and Linear Growth in Prepubertal Children: Daily Weight Gain and BMI Changes in Relation to Linear Growth During Nutritional Rehabilitation of Underweight Children.

Soliman Ashraf Tawfik , Itani Maya , Jour Celine , Shaat Mona , Elsiddig Suhair , Souieky Fatima , Al-Naimi Noora

We analyzed the effect of having different BMI and BMI SDS, if any, on linear growth (HtSDS) in a cohort of prepubertal children (n = 102) in different BMI categories. In addition, we studied the effect of weight changes on linear growth in a randomly selected group of underweight children after nutritional rehabilitation (NR).Subjects and Methods: All prepubertal children between 1 and 9 years presented to the general pediatric clin...

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ESPE Abstracts

Body composition following initiation of daily glucocorticoid in Duchenne Muscular Dystrophy: Identifying the timing of increase of fat mass to introduce intensive weight management strategies

Higher Risk of Low Birth Weight and Multiple Nutritional Deficiencies in Neonates from Mothers after Gastric Bypass: A Case Control Study

The effect of growth hormone therapy on linear growth and weight gain in children with growth hormone deficiency vs idiopathic short stature (ISS) a controlled study

A Phase 2 Trial of the Melanocortin-4 Receptor Agonist Setmelanotide in Obesity Due to SRC1 Insufficiency: Body Weight, Body Mass Index Z Score, and Safety Results

Novel insights into weight regulation

“Screening for congenital hypothyroidism in preterm newborns: Thyroid Stimulating Hormone (TSH) percentiles for weight and gestational age and congenital hypothyroidism features”

Greater Maternal BMI Early in Pregnancy and Excessive Gestational Weight Gain are Independently Associated with Adverse Health Outcomes in the Offspring at Age 7 Years

Age at Onset of Weight Gain in Prader–Willi Syndrome is Often Between 1 and 2 Years, Preceding the Hyperphagic Phase; Implications for Management

Improvement in Health-Related Quality of Life scores in Children and Young people with Obesity following intervention and support from a Tertiary MDT Weight Management Service

The Relation Between Changes in Body Mass Index (BMI) and Linear Growth in Prepubertal Children: Daily Weight Gain and BMI Changes in Relation to Linear Growth During Nutritional Rehabilitation of Underweight Children.

BiosciAbstracts