hrp0092s2.3 | Novel Mechanisms and Therapies in Bone and Growth Plate: Investing in the Future Health of Children | ESPE2019

Glucocorticoid-Induced Osteoporosis in Children: Targeting the Spine in Osteoporosis Diagnosis, Monitoring and Treatment

Ward Leanne M.

Despite significant advances in the medical management of childhood diseases, glucocorticoids (GCs) continue to be the mainstay of therapy for numerous serious conditions, including hematological malignancies, Duchenne muscular dystrophy (DMD) and inflammatory disorders. In order to understand the natural history of bone development in GC-treated children, a pan-Canadian longitudinal observational research study called "STOPP" (STeroid...

hrp0089ss1.2 | Special Symposia: Nutrition and Growth | ESPE2018

Fascinating Growth Phenomena: What Causes Individual Catch-up Growth and Population Secular Change?

Wit Jan M

Catch-up growth (CUG) is characterized by a period of supranormal height velocity following a transient period of growth inhibition. The two classical hypotheses on the mechanism are the neuro-endocrine hypothesis (a central mechanism that would recognize the degree of mismatch between actual size and target size) and the growth plate hypothesis (local regulation of growth according to a preset cellular program of senescence, characterized by decreasing growth proliferation ra...

hrp0084p3-705 | Diabetes | ESPE2015

Treatment of Dyslipidemia in Children and Adolescents with Diabetes Mellitus Type 1

Borgerink M M H , van Albada M A , Venema G , Bakker-van Waarde W M

Background: Cardiovascular disease (CVD) is the major cause of mortality in diabetes mellitus type 1 (T1DM). Dyslipidemia will increase this risk. Several guidelines have been published, how to treat dyslipidemia in T1DM, yet some studies have shown that the number of patients who are treated according to these guidelines is low.Objective and hypotheses: To investigate the frequency of dyslipidemia in children and adolescents with T1DM and if they are tr...

hrp0097s12.1 | What's new for the HPG Axis | ESPE2023

Minipuberty - Looking into the future

Main Katharina M.

The transient activation of the hypothalamus-pituitary-gonadal (HPG) axis shortly after birth has been described as early as in the 70ies. This discovery has since been applied clinically as a ‘window of opportunity’ for diagnostic evaluation of patients suspected of endocrine disorders and differences of sex development. With the advent of increasingly more sensitive and specific analytical methods for peptide and steroid hormones produced in the pituitary, gonads...

hrp0094fc5.2 | Sex Development and Gender Incongruence | ESPE2021

Unexpected impact of sex hormones on B-cells in trans- and cis-gendered healthy young people

Peckham Hannah , Rosser Elizabeth C , Radziszewska Anna , Robinson George , Martin-Gutierrez Lucia , De Gruijter Nina M , Jury Elizabeth C , Butler Gary E , Ciurtin Coziana ,

Background: Cis-gender females are known to mount stronger immune responses to invading pathogens or vaccines than cis-gender males. However, this is also associated with increased risk of autoimmunity. Little is known about the immunophenotypes of transgender individuals on gender-affirming hormonal treatment, despite growing evidence that hormones influence the immune system. Via the process of class-switch recombination (CSR), B-cell immunoglobulin isotype ...

hrp0098p3-321 | Late Breaking | ESPE2024

Etiological aspects of growth failure

Benyahya Nadia , Rhouzali Khawla , Hamdane Chaymae , Bouichrat Nisrine , Rouf Siham , Latrech Hanane

Introduction: Short stature is a common cause of consultation in the endocrinology department, It can be a sign of many affections or hereditary conditions. A clear and rapid diagnostic procedure is imperative for the improvement of height prognosis. The present study sought to evaluate the etiological profile of short stature in childrenPatients and Methods: This is a retrospective study of 292 patients admitted for del...

hrp0098p2-106 | Fat, Metabolism and Obesity | ESPE2024

Comparative Analysis of the Discriminative Ability of BMI, TMI, and BMI zscore in Establishing Metabolic Syndrome Risk

Domingo-Ajenjo Julia , Torres-Martos Álvaro , Bustos-Aibar Mireia , Arteaga Maria , Vázquez-Cobela Rocio , Nagore Carlos , De Miguel Pilar , Alcalá-Fdez Jesús , Anguita-Ruiz Augusto , Leis Rosaura , M. Aguilera Concepción , Bueno-Lozano Gloria

Pediatric obesity is intimately related to the development of Metabolic Syndrome (MetS), which is a cluster of metabolic alterations associated with an increased risk of premature death. Some indexes of obesity, such as the Triponderal Mass Index (TMI), Body Mass Index (BMI), and Body Mass Index z-score (BMI-zscore), are used to identify children at high risk. This study aims to compare the discriminative ability of BMI, BMI and BMI-zscore to determine the risk of developing M...

hrp0097p1-177 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2023

The consistency between Assigned Gender and Individual Gender Identity in Disorder of Sex Development Cases: Long-Term Results from a Single Center

Jalilova Arzu , Özen Samim , Yuluğ Taş Begüm , Kızılay Özalp Deniz , Ece Solmaz Aslı , Gül Balkı Hanife , Tekin Ali , Arslan Emrullah , Atik Tahir , Gülpınar Kübra , Çoğulu Özgür , Ünal Kocabaş Gökçen , Özbaran Burcu , Onay Hüseyin , Ulman İbrahim , Özkınay Ferda , Saygılı Füsun , Gökşen Damla , Darcan Şükran

Introduction: In cases of disorder of sex development (DSD), the change between the gender assigned at birth and the individual's chosen gender identity can occur especially after puberty.Aim: was to determine the relationship between genetic sex, gender assigned at birth and gender identity, and the importance of molecular diagnosis.Method:154patients older than 14years of ag...

hrp0092p1-79 | GH and IGFs | ESPE2019

The experience of Pain in Children with Growth Hormone Deficiency and Psychosocial Correlates: Preliminary Data from a Longitudinal Prospective Study

Bettini Alessandra , Teodori Caterina , Maffei Francesca , Ciofi Daniele , Stagi Stefano

Background: Pain represents one of the most stressful experiences for children undergoing medical therapies (Kortesluoma, 2008), but is under represented in literature for what concerns pediatric endocrinology. Children consider Injections one of the most painful, frighteningand distressing procedures (Fassler, 1985). The treatment for patients with Growth Hormone Deficiency requires daily subcutaneous injection, performed by parents or patients themselves. Th...

hrp0092p2-270 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2019

Follow-up of Individuals with Gender Identity Disorders: A Long and Challenging Process

Ozturan Esin Karakilic , Ozturk Ayse Pinar , Kardelen Al Asli Derya , Poyrazoglu Sukran , Bas Firdevs , Ayaz Ayse Burcu , Yuksel Sahika , Darendeliler Feyza

Background/Aim: Gender identity disorder (GID) is a condition, which is characterized by incongruence between experienced gender and the natal-sex, which also causes deterioration of functionality. After psychiatric evaluations, medical treatment for adolescents with GID consists of 3 phases. First phase is the suppression of puberty with GnRH-analogues, which may be considered to be supporting the diagnostic process. In the second phase, cross-sex steroid hor...