hrp0095p2-34 | Bone, Growth Plate and Mineral Metabolism | ESPE2022

Optimal 25-OH-Vitamin D level in children derived from metabolic parameters

Gillis David , Hefter Ari , Edri Edri Shalom , Strich David

Context: Optimal levels of 25-OH-Vitamin D (25OHD) for children are unknown. Prevalent population levels of 25OHD are likely to be sub-optimal since sun exposure is reduced in modern living.Objective: To deduce recommended levels of 25OHD by testing, in children, the level at which 25OHD optimally effects calcium, phosphate and parathyroid hormone levels in a population-based data.Design:</...

hrp0094p2-82 | Bone, growth plate and mineral metabolism | ESPE2021

Vitamin D - What is the Optimal Level in the Pediatric Population

Gillis David , Hefter Ari , Edri Shalom , Strich David ,

Introduction: The optimal level of 25-OH-Vitamin D in children is not clear since most studies have been performed on adults. Creating normal levels is problematic since the recommended level of vitamin D is based on the effect of vitamin D on other parameters and not upon its level in the population.Methods: This is a "big-data" study in which we analyzed Vitamin D tests from 49,935 children sampled in Clalit He...

hrp0097p2-34 | Fat, Metabolism and Obesity | ESPE2023

Case Report: Massive Obesity secondary to a Homozygous MC4R mutation in a 3-year-old Boy

Gillis David , Hefter Ari , Edri Edri Shalom , Strich David

We present a 3-year-old boy with massive obesity and hyperphagia. His appetite symptoms were evident from age 3 months, and his parents report he has an insatiable appetite, and seeks food constantly. At presentation to our clinic, his BMI was 37.21 Kg/m² [+ 6.87 SDS]. Sleep apnoea is suspected, for which he is undergoing evaluation. Parents are second cousins. Both parents are moderately obese, but his siblings are normal weight for age. The mother did not have a history...

hrp0098p1-161 | GH and IGFs 2 | ESPE2024

Obesity/overweight – an unjustified obstacle to growth hormone treatment

Strich David , Meirman Cherut , Edri Shalom , Gillis David

Objective: Peak stimulated growth hormone (GH) levels are lower in overweight and obese subjects and it has been suggested that results of tests should be adjusted for body mass index (BMI). The study aimed - A. To evaluate the association between growth hormone peak levels and body mass index (BMI) in a single center. B. To discuss the biological and clinical significance of the findings and make recommendations based on a literature review.<p class="abst...

hrp0086p1-p113 | Bone &amp; Mineral Metabolism P1 | ESPE2016

Extension of The Bone Health Index to Adults, and Reference Curves of Four Indices of Cortical Bone for Healthy Europeans

Martin David , Thodberg Hans Henrik

Background: The BoneXpert method for automated determination of bone age from hand X-rays has always included a determination of the Bone Health Index (BHI) from the cortical thicknesses in the metacarpals.Objective and hypotheses: The aim was to extend this so-called digital X-ray radiogrammetry method into adults, and present reference curves for BHI and three other indices: the metacarpal index, the Exton-Smith index and the volume-per-area (proportio...

hrp0086p1-p114 | Bone &amp; Mineral Metabolism P1 | ESPE2016

Extension of Automated Bone Age Determination to the End of Puberty

Martin David , Thodberg Hans Henrik

Background: The BoneXpert method for automated determination of bone age (BA) from hand X-rays was introduced in 2009, covering the Greulich-Pyle BA range up to 17 years for boys and 15 years for girls.Objective and hypotheses: To present an extension of the BA range of the automated method up to 19 years for boys and 18 years for girls and to validate it against manual rating.Method: The extension was developed based on images fro...

hrp0097p1-41 | Diabetes and Insulin | ESPE2023

ADIPOQ gene (adiponectin) causing neonatal diabetes mellitus in a Palestinian newborn

Abu-Libdeh Abdulsalam , Zanged David

Background: Monogenic diabetes is a type of diabetes resulting from mutations of a single gene that may be spontaneous de novo or autosomal dominant or recessive. Reported incidence is 1-4% and confirmed by molecular genetic testing. Transient neonatal diabetes is usually diagnosed within the first week of life and resolves around 12 weeks. Permanent neonatal diabetes should be considered in all children presenting with diabetes in first month of age, and do n...

hrp0092fc2.6 | Bone, Growth Plate and Mineral Metabolism Session 1 | ESPE2019

Validation of a New Version of BoneXpert Bone Age in Children with Congenital Adrenal Hyperplasia (CAH), Precocious Puberty (PP), Growth Hormone Deficiency (GHD), Turner Syndrome (TS), and other Short Stature Diagnoses

Thodberg Hans Henrik , Martin David D

Background: The BoneXpert method for automated determination of bone age from hand X-rays is based on machine learning, so it lends itself naturally to be improved by adding more training data and using better learning algorithms. Currently, version 2 is running in 145 hospitals across Europe, and a new version 3 is rolled out in 2019.Objective and Hypotheses: The aim was to validate version 3 against manual ratings in r...

hrp0086rfc7.7 | Gonads &amp; DSD | ESPE2016

Clinical Decision-Making in Disorders of Sex Development (DSD): Physician Recommendations Pre- and Post-Consensus Statement

Sandberg David E. , Kogan Barry , Gardner Melissa

Background: Despite advances in genetic diagnosis and surgical technique, and guidance from the Consensus Statement on Intersex Disorders, aspects of clinical management in disorders/differences of sex development (DSD) remain unsettled. Actively debated decision points include gender of rearing in specific syndromes, genital surgery prior to the patient developing the capacity to provide assent, and uncertainty over how and when to best educate young patients about diagnostic...

hrp0086p2-p424 | Gonads &amp; DSD P2 | ESPE2016

Follow-up to Adulthood of Two 46,XY Siblings with 5-alpha Reductase Deficiency and Different Sex of Rearing

Chiniara Lyne , Sandberg David , Van Vliet Guy

Background: 46,XY patients with 5α-reductase deficiency (5-ARD), reared from birth as girls, are reported to self-reassign as boys subsequent to a masculinizing puberty; whether this holds true in cases of early orchidectomy is less well documented.Objective and hypotheses: Prepubertal orchidectomy reduces the likelihood of gender self-reassignment.Method: Presentation, management and outcome of two siblings with 5-ARD with na...