hrp0086p2-p576 | Perinatal Endocrinology P2 | ESPE2016

The Postnatal Effect of Serum Vitamin D Binding Protein on Serum Vitamin D Level

Doneray Hakan , Yesilcibik Remziye Seda , Laloglu Esra , Orbak Zerrin

Background: It is not an uncommon situation that newborns have normal serum Ca, P, Mg, ALP, and PTH levels despite low vitamin D. Serum vitamin D binding protein (VDBG) may play a role for this situation. However, there is no any study investigated the relationship between serum vitamin D and VDBP in postnatal period.Objective and hypotheses: The aim of this study is to examine the relationship between serum vitamin D level and VDBP in neonates who have ...

hrp0082p3-d2-996 | Thyroid (1) | ESPE2014

Report of a Hurthle Cell Neoplasm in a Boy

Orbak Zerrin , Cayir Atilla , Doneray Hakan , Oral Akgun , Gursan Nesrin

Background: Thyroid nodules are rare in children compared to adults. Although most thyroid nodules are benign, the risk of malignancy is greater in pediatric patients.Case: We described a 10-year-old boy who presented with a right sided thyroid nodule that was 12×8 mm. He had not cervical lymphadenopathy. His fine needle aspiration biopsy cytology was benign. It was subsequently diagnosed as a Hurthle cell adenoma after thyroidectomy. In histopathol...

hrp0084p3-1088 | Perinatal | ESPE2015

Leptin and Neuropeptide Y Levels in Newborns

Kaya Avni , Orbak Zerrin , Polat Ismail , Polat Harun , Gumusdere Musa

Background: Several studies have investigated leptin and NPY levels in children, but the information for newborns in the literature is limited.Objective and hypotheses: The aim of this study was to determine leptin and neuropeptide Y (NPY) levels in between 14 and 28-days newborns.Method: This prospective study was performed in the Erzurum Atatürk University Medical Faculty Research Hospital Neonatal Clinic, Turkey, between Ju...

hrp0094p2-95 | Bone, growth plate and mineral metabolism | ESPE2021

Effect of cholecalciferol treatment on serum FGF-23, vitamin D-binding globulin and α-klotho levels in children with vitamin D deficiency

Tosun Ilker , Orbak Zerrin , Doneray Hakan , Ozturk Nurinnisa ,

Introduction and Aim: FGF-23 is a hormone that works by inhibiting phosphorus reabsorption in kidneys, and systematic regulation of phosphate homeostasis by FGF23 depends on the activity of the membrane protein Klotho. It affects the active vitamin level according to the bioactive free vitamin hypothesis, which binds DVBP to vitamin D and prolongs its half-life. In this study, it was aimed to investigate 1.25 (OH) Vitamin D, Vitamin D Binding Protein, FGF-23 a...

hrp0092p2-42 | Bone, Growth Plate and Mineral Metabolism | ESPE2019

Stuve-Wiedemann Syndrome: A Case Report without Osteorosis

Orbak Zerrin , Yüce Kahraman Çigdem , Orbak Recep , Özden Ayse , Tatar Abdulgani

Stüve-Wiedemann syndrome (SWS) is an autosomal recessive disorder characterized by bowing of the long bones and other skeletal anomalies, neuromuscular abnormalities, dysautonomic symptoms, and respiratory and feeding distress usually resulting in early death.We report a girl, aged 6 years, with SWS. We measured bone mineral density in the lumbar spine, using dual-energy x-ray absorptiometry (DXA) with a densitometer (Hologic). The result is express...

hrp0089p3-p096 | Diabetes & Insulin P3 | ESPE2018

Serum Trace Element Levels in Children Presenting with Diabetic Ketozis and Diabetic Ketoacidosis: A Longitudinal Controlled Study

Doneray Hakan , Gurbuz Kadri , Ozden Ayse , Gul Mehmet Ali , Orbak Zerrin

Objective: There have been very few studies, with contradictory results, on the serum trace elements in children and adolescents presenting with diabetic ketosis and diabetic ketoacidosis due to type-1 diabetes mellitus. The objective of this longitudinal controlled study was to determine serum trace element status including selenium (Se), zinc (Zn), copper (Cu), manganese (Mn), chrome (Cr), and cobalt (Co) in type-1 diabetic children and adolescents presenting with diabetic k...

hrp0082p3-d3-754 | Diabetes (4) | ESPE2014

Ketoacidosis-Associated Stroke: Cerebral Infarction

Orbak Zerrin , Doneray Hakan , Yesilcibik Seda , Kantarci Mecit , Tan Huseyin , Kucuk Nuran , Kosan Celalettin

Background: Type 1 diabetes mellitus (T1DM) is a common autoimmune condition in childhood and may be complicated by episodes of diabetic ketoacidosis (DKA). DKA is a state of severe insulin deficiency, resulting in hyperglycemia, ketonemia, acidemia, and systemic inflammation. This is predominantly attributable to intracerebral complications. We report a girl with a newly diagnosed T1DM who presented with DKA and cerebral infarction.Case: A 13-year-old p...

hrp0084p3-1084 | Perinatal | ESPE2015

Plasma Kisspeptin Levels of Infants Breast Growth in Neonatal Period

Kaya Avni , Orbak Zerrin , Polat Harun , Cayir Atilla , Erdil Abdullah , Doneray Hakan

Background: The studies investigating kisspeptin levels in the neonatal period is very limited.Objective and hypotheses: This study was intended to investigate plasma kisspeptin hormone levels in newborns with or without breast growth.Method: This prospective study was performed to determine plasma hormone levels of kisspeptin in patients admitted to the Erzurum Ataturk University Faculty of Medicine Research and Educational Hospit...

hrp0097p2-180 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2023

SRY-positive 45, X male with monoorchism and hypospadias

Orbak Zerrin , Demir Busra , Yüce Kahraman Çiğdem , Fırıncı Binali

A rare case of a 4-year-old boy with a SRY-positive 45, X karyotype was presented. Family history of the child was not remarkable. His height and weight were -2.1 SD and -1.4 SD, respectively. Physical examination revealed a well-developed penis with hypospadias. His right testis was in the scrotum and the left testis was not palpable. In previous inguinal exploration recordings, unilateral testicular agenesis on the left side were noted. The right testis was biopsied and prep...

hrp0092lb-2 | Late Breaking Posters | ESPE2019

The Effects of Different Diets (High Fat and High Fructose Diet) on the Development of Insulin Resistance and Tissue Advanced Glycation End Product Levels in Rats

Demirci Tuba , Orbak Zerrin , Ozturk Nurinnisa , Kaygisiz Merve Durmus , Nalci Kemal Alp , Polat Zeliha Başak

Introduction & Objectives: Fat and fructose-rich nutrition bring many metabolic diseases, especially obesity and diabetes. Recent years, more scientific interest in how can diet effect on brain function has emerged. We aimed to investigate the effect of high fructose and high-fat diet on the brain, and whether the presence of relationship with advanced glycation end products histologically, in rat model.Materials & Method...