hrp0089p1-p065 | Diabetes & Insulin P1 | ESPE2018

Evaluation of Diabetes Related Complications and Endothelial Dysfunction in Adolescents with Type 1 Diabetes

Metwally Nehad , Macken Alan , O'Regan Myra , Fitzgerald Helen , McDonnell Ciara , O'Gorman Clodagh S , Molloy Eleanor , Roche Edna F

Introduction: Patients with type 1 diabetes (T1D) are at high risk of developing vascular complications. Endothelial dysfunction is considered the early reversible stage in the development of diabetes related vascular disease. Early detection and management of endothelial dysfunction can delay or even prevent the development of vascular complications.Aim: Endothelial dysfunction is associated with poor metabolic control in adolescents with T1D. Based on ...

hrp0084p3-917 | GH & IGF | ESPE2015

Serum IGFI Concentration and Growth During Infancy Correlate to Polyunsaturated Fatty Acid Pattern

Dahlgren Jovanna , Kjellberg Emma , Strandvik Birgitta , Roswall Josefine

Background: IGF1 is important for fetal and infant growth and is influenced by nutrition. In young pigs, docosahexaenoic acid (DHA)-enriched food is associated with higher IGF1 levels but studies in human infants are lacking.Aims and objectives: To assess levels of polyunsaturated fatty acids (PUFA) relate to IGF1, birth size and growth during infancy.Methods: The setting was a population-based longitudinal cohort comprising 126 fu...

hrp0097p1-247 | Fat, Metabolism and Obesity | ESPE2023

Th17 lymphocytes and peripheral complete blood count alterations in obese children

Artemniak-Wojtowicz Dorota , M. Kucharska Anna , Stelmaszczyk-Emmel Anna , Majcher Anna , Rumińska Małgorzata , Pyrżak Beata

Introduction: Obesity is considered one of the most common chronic diseases worldwide which is associated with chronic, low-grade, sterile inflammation. It leads to variable changes in metabolic and hormonal homeostasis. The aim of our study was to evaluate the impact of obesity associated chronic inflammation on peripheral complete blood count alterations.Material and Methods: 27 overweight/obese and 15 normal-weight ch...

hrp0092rfc6.2 | Bone, Growth Plate and Mineral Metabolism Session 2 | ESPE2019

High Levels of LIGHT/TNFSF14 in Prader-Willi Syndrome

Brunetti Giacomina , Fintini Danilo , Crinò Antonino , Piacente Laura , Convertino Alessio , Concetta Colucci Silvia , Grano Maria , Grugni Graziano , Faienza Maria Felicia

Background: Low bone mineral density (BMD) has been found in up to 50% of adolescents and adults with Prader-Willi syndrome (PWS). High fracture risk has been described in adult PWS patients. However, the mechanism/s of low BMD in PWS have not been clarified. These patients also display high BMI-SDS that prompted us to evaluate the levels of LIGHTTNFSF14, a cytokine involved in pathological bone remodeling and obesity.Objecti...

hrp0086rfc1.8 | Adrenals | ESPE2016

Adrenal Dysfunction in HIV-Exposed Uninfected Infants Receiving Ritonavir-Boosted Lopinavir, an HIV Protease Inhibitor, for the Prevention of Breastfeeding HIV Transmission. An ANRS 12174 Substudy

Polak Michel , Wudy Stefan , Meda Nicolas , Hartmann Michaela , Kankasa Chipepo , Tumwine James , Laborde Kathleen , Hofmeyr Justus , Vallo Roselyne , Nagot Nicolas , Tylleskar Thorkild , Van de Perre Philippe , Blanche Stephane

Background: We recently demonstrated that both ritonavir-boosted lopinavir (LPV/r) and lamivudine (3TC, a nucleoside analogue) given to breastfed infants can reduce the risk of post natal HIV transmission (ANRS 12174 trial; Nagot, Lancet 2016). In another setting we previously showed the occurrence of adrenal dysfunction in newborn perinatally exposed to LPV/r leading to acute adrenal insufficiency in premature babies (Simon, JAMA 2011).Objective and hyp...

hrp0084fc1.3 | Adrenal | ESPE2015

Aldosterone and Mineralocorticoid Receptor as Inducers of Immune Markers in Peripheral Blood Mononuclear Cells: Beyond Elevating Blood Pressure

Vecchiola Andrea , Munoz-Durango Natalia , Cifuentes Mariana , Lagos Carlos , Fuentes Cristobal , Gonzalez Luis-Martin , Ortiz David , Carvajal Cristian , Tapia-Castillo Alejandra , Valdivia Carolina , Martinez-Aguayo Alejandro , Allende Fidel , Solari Sandra , Bancalari Rodrigo , Garcia Hernan , Campino Carmen , Baudrand Rene , Kalergis Alexis , Fardella Carlos E

Background: In vitro studies suggest a broader role for aldosterone, beyond elevating blood pressure. Clinical data support the notion that aldosterone can directly alter the function of the immune system and can participate in low-grade inflammation which leads to blood pressure elevation and end organ damage.Objective and hypothesis: To assess in humans, whether aldosterone plasma levels and mineralocorticoid receptor (MR) expression associate...

hrp0098p2-198 | Multisystem Endocrine Disorders | ESPE2024

A Correlation Study Between Iron Overload, Chelation Therapy (ICT), and Metabolic Outcomes in β-Thalassemia Major (β-TDT) Patients

De Sanctis Vincenzo , Soliman CAshraf , Daar Shahina , Campisi Saveria , Tzoulis Ploutarchos

Introduction and Aim: We conducted this correlation study to analyze the impact of iron overload and chelation therapy on metabolic outcomes in 30 β-Thalassemia Major (β-TDT) patients, divided into those with prediabetes (Group A, n = 15) and those maintaining normal glucose tolerance (Group B, n = 15) over 8 years of consistent iron chelation therapy (ICT).Results: A negative correlation betw...

hrp0089p3-p293 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Two Identical Twins … But not in Everything. A Difficult Diagnosis

Damia Chiara Maria , Gallo Dario , Partenope Cristina , Pitea Marco , Fioretti Lorenzo , Adavastro Marta , Pajno Roberta , Weber Giovanna , Barera Graziano

GR and GT are diamniotic monochorial preterm twins (32 GA), both AGA (GR: W -1 SDS, L -1.5 SDS; GT: W and L 0 SDS), with normal karyotype and array-CGH on amniotic fluid, with no major complications associated to prematurity. At birth GT presented bilaterally cryptorchidism associated with micropenis, GR presented normal male genitalia. In the first year of life a severe growth deceleration in length (from -3SDS to -5 SDS) was observed, mainly after six months of life in both ...

hrp0086p2-p304 | Diabetes P2 | ESPE2016

Cardiovascular Risk and Long Term Follow-up of Turkish Children with Type 2 Diabetes: Single Center Experience

Guven Ayla , Demir Elif Gokce

Background: Type 2 diabetes (T2DM) increases in parallel with obesity in childhood. T2DM can be associated with cardiovascular risk (CVR) even childhood.Objective: To investigate the presence of CVR criterions in children with T2DM and to detect CVR as the earliest age as possible.Method: This study enrolled 84 (58 Girls) children with T2DM. OGTT was performed in 47 children. Biochemical and hormonal analyses were performed in fast...

hrp0082p2-d3-345 | Diabetes (2) | ESPE2014

Improvement in Type 1 Diabetes Mellitus Metabolic Control: From Conventional to Functional Insulin Therapy

Serra-Caetano Joana , Ferreira Sara , Lourenco Helena , Aveiro Lina , Batista Nanci , Freitas Filomena , Simao Luisa , Cardoso Rita , Dinis Isabel , Mirante Alice

Background: Type 1 diabetes mellitus (1DM) is a common chronic disease of childhood. Treatment targets the best metabolic control in order to prevent long-term complications.Objective: To evaluate metabolic control in children and adolescents with 1DM along the years. Methods: Retrospective study including 1DM children and adolescents with more than 2 years of disease. Data were collected at 2005 and at 2012: sex, age at diagnosis, therapy in the last ye...