hrp0084p2-285 | Diabetes | ESPE2015

Implementation of Effective Transition from Paediatric to Adult Diabetes Care: Epidemiological and Clinical Characteristics – A Pioneering Experience in North Africa

Leila Essaddam , Zinet Turki , Zohra Fitouri , Claude Ben Slama , Nadia Matoussi , Saayda Ben Becher

Background: Diabetes mellitus (DM) is a chronic metabolic disorder requiring daily care to prevent both acute and chronic complications. Healthcare providers are challenged to manage the transition of adolescents from paediatric to adult diabetes services. Until recent date, this change of the medical team was lived by teenagers as a tearing and a discontinuity of the medical care.Objective and hypotheses: While centres providing structured integrated pa...

hrp0098fc15.2 | Late Breaking | ESPE2024

Amount and Pattern Of Pulsatile GH Secretion Induced By The Oral Growth Hormone Secretagogue LUM-201 Is Related To Growth And IGF-1 Responses In Moderate Pediatric Growth Hormone Deficiency (PGHD)

Roslan Amirul , Román Rossana , Avila Alejandra , Said Daniela , Baier Ingrid , L. Brincks Erik , Bruchey Aleksandra , C. McKew John , Duke Pitukcheewanont Pisit , L. Johnson Michael , Garner Terence , O. Thorner Michael , E. Clayton Peter , Stevens Adam , Cassorla Fernando

Background: Oral LUM-201 normalizes growth rates in moderate PGHD over 12 months (Phase 2 Trials: OraGrowtH210/OraGrowtH212) [FC-746 ESPE 2024]. In OraGrowtH212, GH profiles, based on 10-minute sampling over 12 hours (8am-8pm), showed significant increases in inter-pulse, pulsatile and total GH secretion in response to 1.6 and 3.2 mg/kg/day doses of LUM-201 over 6 months, with no difference between the doses [FC14.3, ESPE 2023].O...

hrp0095lb1 | Late Breaking | ESPE2022

Amenorrhea in an Anorexia Nervosa patient as a presenting symptom of Cushing’s disease.

Avnon Ziv Carmit , T. Ben Harush Negari Shelly

Anorexia nervosa (AN) manifests in the restriction of energy intake relative to energy output. Atypical AN includes those who meet the criteria for AN but are not underweight. Hypothalamic amenorrhea can be a presenting symptom in AN, and the return of menses is part of recovery. It can take more than a year for menses to return after weight restoration and nutritional rehabilitation. Hypercortisolemia is common in AN, but usually does not cause cushingoid symptoms We describe...

hrp0092p2-134 | Fat, Metabolism and Obesity | ESPE2019

Tumor Necrosis Factor Alpha in Metabolic Syndrome Development in Children

Ben-Skowronek Iwona , Kapczuk Iga , Mroczek Wacinska Joanna

Background: Tumor necrosis factor alpha (cachexin) is a cell signaling cytokine involved in systemic inflammation process. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. The primary role of TNF alpha is the regulation of immune cells. TNF, being an endogenous pyrogen, is able to induce fever, apoptotic cell death, an...

hrp0089p2-p223 | GH & IGFs P2 | ESPE2018

Health Lifestyle and Obesity of Adult Patients with Congenital Isolated Growth Hormone Deficiency Treated in Childhood

Nun-Yaari Efrat Ben , Kauli Rivka , Lilos Pearl , Laron Zvi

Background: Data on congenital isolated growth hormone deficiency (cIGHD), mostly due to consanguinity, treated in childhood and followed into adult age is very rare and on few patients.Aim: To assess the clinical and social characteristics of adults with cIGHD who were treated in childhood and followed thereafter.Subjects: Thirty nine patients with cIGHD from our clinic were followed into adult age (mean age 30.7±13.3). All w...

hrp0089p1-p247 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P1 | ESPE2018

Evaluation of Hormonal Profiles and Autoantibodies Against Sperm and Leydig Cells in Patients after Testicular Torsion Treatment

Osemlak Pawel , Miszczuk Konrad , Jedrzejewski Grzegorz , Ben-Skowronek Iwona

Background: Proper endocrine function of testicles is essential for the healthy development of children and for adult life.Methods: Hormonal profiles of patients (aged 1–18 years) were evaluated several years after surgical testicular torsion treatment. Blood samples were obtained between 11a.m and 1p.m. to measure serum levels of FSH, LH, AMH, testosterone, VEGF-A total, IGF-1, IGFBP-3 and autoantibodies against sperm and Leydig cells.<p class=...

hrp0086p2-p530 | Fat Metabolism and Obesity P2 | ESPE2016

Vascular Endothelial Growth Factor as The Predictor Microangiopathy in Obese and Diabetic Children

Ben-Skowronek Iwona , Kapczuk Iga , Stapor Natalia , Banecka Bozena

Background: Vascular endothelial growth factor (VEGF) is a signal protein produced by cells that stimulates vasculogenesis and angiogenesis. It is part of the system that restores the oxygen supply to tissues when blood circulation is inadequate. Serum concentration of VEGF is high in bronchial asthma and diabetes mellitus. Overexpression of VEGF can cause vascular disease in the retina of the eye and other parts of the body.Objective and hypotheses: The...

hrp0082p3-d1-978 | Thyroid | ESPE2014

Treatment the Resistance to Thyroid Hormones in Girl

Budzynska Elzbieta , Ben-Skowronek Iwona , Korobowicz Elzbieta , Klatka Maria

Background: The cardinal feature of the resistance to thyroid hormone (RTH) is reduced responsiveness of target tissues to thyroid hormone action caused by thyroid hormone receptor β gene (THRB) mutations impairing hormone binding in the majority (90%) of cases. It results in elevated serum levels of free thyroxine (FT4) and triiodothyronine (FT3) associated with unsuppressed thyroid SH.Objective and hypotheses: The ai...

hrp0084p2-443 | Gonads | ESPE2015

Usefulness of 3D Ultrasonography for Assessment of the Morphology of the Ovary in Adolescents with Hyperandrogenism

Ben-Skowronek Iwona , Budzynska Elzbieta , Wozniak Magdalena , Wieczorek Pawel

Background: Polycystic ovary morphology (PCOM) in USG should not be identified with polycystic ovary syndrome (PCOS) and it is not a criterion for diagnosis of this syndrome in adolescents.Objective and hypotheses: Assessment of the usability of 3D ultrasonography in diagnostics of androgen excess disorders.Method: 40 girls aged 14–18 with hyperandrogenism were subjected to endocrinological examinations and transrectal USG of ...

hrp0094p2-105 | Diabetes and insulin | ESPE2021

Recurrent episodes of hypoglycemia in an infant with type 1 spinal muscular atrophy after gene therapy: Beta oxidation defect exaggerated by hepatic dysfunction.

Alaaraj Nada , Hamed Noor , Soliman Ashraf , Omran Tawfeg Ben ,

Introduction: Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease. In 2016, nusinersen (Spinraza) was approved by the FDA. The first AAV9-based gene therapy (Zolgensma), was approved by the FDA (2019) for the treatment of infants with SMA. We report an SMA case with recurrent hypoglycemic events after gene therapy.Case Report: A 22 months old boy, with SMA type 1 was born at term by CS for fetal bradycardia....