hrp0097p1-197 | Thyroid | ESPE2023

Effects of methimazole therapy on effector T and B regulatory cells in pediatric patients with Graves' disease

Stożek Karolina , Grubczak Kamil , Starosz Aleksandra , Bossowski Filip , Moniuszko Marcin , Bossowski Artur

Introduction: The incidence of autoimmune thyroid diseases (ATD) is constantly rising. Graves’ disease (GD) remains the most common cause of thyrotoxicosis in pediatric population, but the exact pathogenesis of GD is still not fully understood. The immunological basis of ATD assumes an imbalance between effector and regulatory T lymphocytes. B regulatory cells (Breg) are able to suppress the pro-inflammatory properties of effector T cells. Methimazole (M...

hrp0098p1-288 | Thyroid 3 | ESPE2024

Assessment of regulatory B cells in peripheral blood and zinc transporter 8 expression in thyroid tissue in children with autoimmune thyroid diseases

Stożek Karolina , Starosz Aleksandra , Opęchowska Aleksandra , Bossowski Filip , Moniuszko Marcin , Grubczak Kamil , Bossowski Artur

Introduction: There has been a growing trend in the incidence of autoimmune thyroid diseases (ATD) in the pediatric group of patients. The new aspects of its pathogenesis may contribute to understand innovative methods of prevention and treatment. Regulatory B cells (Breg) allow the maintenance of immune homeostasis by neutralizing the negative reactions of effector cells. Attention has been recently paid also to the new environmental factor like zinc and its ...

hrp0084p2-566 | Thyroid | ESPE2015

Analysis of B Regulatory Cells with Phenotype CD19+CD24hiCD27+IL-10+ and CD19+IL-10+ in the Peripheral Blood of Children with Graves’ Disease and Hashimoto’s Thyroiditis

Bossowski Artur , Grubczak Kamil , Singh Paulina , Radzikowska Urszula , Dabrowska Milena , Sawicka Beata , Bossowska Anna , Moniuszko Marcin

Background: Autoimmune thyroid disease (AITD) is the most common organ-specific autoimmune disorder. Genetic background, environmental and endogenous factors are play important roles in determining the activation of immune cells or the efficacy of the immunoregulatory pathways. Recently emphasizes the immunosuppressive role of B regulatory cells (phenotype CD19+CD24hiCD27+IL-10+, CD19+IL-10+) in regulation of immune respon...

hrp0089p1-p265 | Thyroid P1 | ESPE2018

HLA Alleles and Amino Acid Variants of HLA-A, -B, -C, -DRB1, -DQB1, -DPB1 Molecules in Early-Onset Autoimmune Thyroid Disease

Cho Won Kyoung , Shin Dong Hwan , Kim Seul Ki , Lee Seonhwa , Choi Yujung , Ahn Moonbae , Baek In Cheol , Jung Min Ho , Kim Tai-Gyu , Suh Byung-Kyu

Objective: We try to investigate the polymorphisms and amino acid variants of HLA-A, -B, -C, -DRB1, -DQB1, -DPB1 molecules in early-onset AITD.Methods: The genotypes of HLA-A, B, C, DRB1, DQB1, and DPB1 on AITD were analyzed in 102 Korean children with AITDs (Graves’ disease (GD)=62, Hashimoto’s disease (HD)=40) and 142 healthy control using sequence-based typing. Analysis of variant amino acids was performed across the genotyping results with ...

hrp0095p1-40 | Diabetes and Insulin | ESPE2022

Pancreatic Shear Wave Elastography in Children with T1D; Relation to Functional B cell mass Pancreatic Reserve

Salah Nouran , Madkour Sherihane , Soliman Khaled

Background: Little is known about the pancreatic changes during type 1diabetes (T1D) progression. Recently shear wave elastography (SWE) has emerged as a tool of pancreatic stiffness assessment in chronic pancreatitis and pancreatic cancer with few studies assessing it in diabetes. Objective: to compare the pancreatic SWE in children with recent-onset and long standing T1D to healthy controls and to correlate it to diabetes-duration, glycemic control (HbA1C), ...

hrp0089p1-p056 | Diabetes & Insulin P1 | ESPE2018

Different Clinical Findings in Maturity Onset Diabetes of the Young due to B-Lymphocyte Kinase Gene Mutations

Guven Ayla , Yildirimoglu Canan

Background: B-Lymphocyte kinase gene (BLK) gene acts on insulin synthesis and secretion, and mapped locus on chromosome 8p23. Monogenic diabetes due to BLK gene mutation is very rare and it’s named as MODY11. We aimed to present differences in clinical, laboratory and treatment of the patients with BLK mutations.Methods: OGTT performed in six patients. A panel of 23 MODY genes was screened. Patients with BLK</e...

hrp0086rfc12.6 | Neuroendocrinology | ESPE2016

Serum Antimüllerian Hormone and Inhibin B as Potential Markers for Progressive Central Precocious Puberty in Girls

Chen Ting , Chen Linqi , Wu Haiying , Xie Rongrong , Chen Xiuli

Background: Anti-Müllerian hormone (AMH) and inhibin B (INHB) are two hormones investigated as markers of ovarian reserve in female. serum AMH and INHB levels change through the progression of puberty, and might be markers for identifying pubertal progression rate in girls.Objective and hypotheses: To invetigate serum AMH and INHB levels as markers of pubertal progression rate in girls with central precocious puberty (CPP).Met...

hrp0082p1-d2-3 | Adrenals &amp; HP Axis | ESPE2014

Transient Generalized Glucocorticoid Hypersensitivity: Clinical Manifestations, Endocrinologic Evaluation, and Transcriptomic Profile: the Potential Role of nf-κb

Nicolaides Nicolas C , Lamprokostopoulou Agaristi , Polyzos Alexandros , Kino Tomoshige , Katsantoni Eleni , Triantafyllou Panagiota , Christophoridis Athanasios , Katzos George , Drakopoulou Maria , Sertedaki Amalia , Chrousos George P , Charmandari Evangelia

Background: Transient generalized glucocorticoid hypersensitivity is a rare disorder characterized by increased tissue sensitivity to glucocorticoids and compensatory hypoactivation of the hypothalamic–pituitary–adrenal (HPA) axis. The condition itself and the molecular mechanisms that underlie its pathophysiology have not been elucidated as yet. Adenovirus 36 has been reported to cause obesity in various animal species.Objective and Hypotheses...

hrp0082p3-d1-762 | Fat Metabolism &amp; Obesity | ESPE2014

A Rare Case of Sea-Blue Histiocytosis Associated with Niemann–Pick Disease Type B in a 8-year and 9-month Old Boy with Hypertension

Ma Hua-mei , Su Zhe , Li Yan-hong

Background: Sea-blue histiocytosis is a morphological finding that can be associated both with acquired conditions of increased cellular turnover and inborn errors of lipid metabolism.Objective and hypotheses: To present a Chinese boy of hypertension and sea-blue histiocytosis secondary to Niemann–Pick disease type B.Methods: Diagnosis was confirmed by the bone marrow aspiration and the specific enzyme assay of leukocytes (def...

hrp0084p2-498 | Perinatal | ESPE2015

Longitudinal Comparison of Inhibin B and AMH Levels and Testicular Volumes between Preterm and Full-Term Infant Boys

Kuiri-Hanninen Tanja , Seuri Raija , Tyrvainen Erja , Dunkel Leo , Sankilampi Ulla

Background: Decreased reproductive rates have been reported in men born prematurely. This potentially relates to an impaired Sertoli cell proliferation during the postnatal hypothalamic-pituitary-gonadal activity, which has been suggested to have a role in later reproductive capacity.Objective and hypotheses: To compare the levels of Sertoli cell markers in premature (PT) and full-term (FT) boys in infancy.Method: Serum AMH and inh...