ESPE Abstracts

Background: Obesity is usually correlated with a higher prevalence of 25OH vitamin D (25OHD) deficiency. This might be due to either volumetric dilution of vitamin D in the large fat mass or its increased uptake by adipose tissue. To our knowledge, a systematic study on 25OHD levels in Prader-Willi syndrome (PWS), a genetic disorder associated with severe obesity, is not available.Objective and hypotheses: To analyze the 25OHD values in a population of p...

Background: The method for assessing adipose tissue thickness using ultrasound has been used extensively in sport medicine. However, the reliability of this method in children was not evaluated. We aim to determine the inter-observer reliability in measuring uncompressed subcutaneous adipose tissue thickness (USAT) using ultrasound, in children.Methods: About 40 healthy children (20 male, 20 female), median age 11.8 years (5.3 to 18.1) were evaluated. Me...

Background: Primary adrenal insufficiency (PAI) is a rare life-threatening disorder. Data on PAI in children are scanty, with the exception of Congenital Adrenal Hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD).Objective and hypotheses: Evaluate etiology of PAI in a large cohort of children and characterize clinical presentation in subjects with PAI not due to 21-OHD.Method: Children followed in eight tertiary centers wer...

Background: BoneXpert software calculates bone health index (BHI) from cortical thickness and mineralisation of three metacarpals, and bone age (BA) using 13 bones: Radius, ulna and bones in ray 1, 3, 5. Strong correlations between BoneXpert BHI and dual-energy x-ray absorptiometry (DXA) and peripheral quantitative computed CT (pQCT) measurements are reported 1. Low bone mineral density (BMD), measured by DXA, and improvement with GH is described in childhood GH deficiency (GH...

Background: Type 1 diabetes mellitus (T1DM) is an important risk factor for cardiovascular events. Endothelial dysfunction and carotid intima-media thickness (CIMT) lead to increased cardiovascular complications. Adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) are markers of early atherosclerosis and play a significant role in developing atherosclerosis. The general aim of the present study was to investigate...

Background: Socioeconomic status (SES) is inversely associated with many chronic diseases, with disadvantaged individuals faring worse than the others. In diabetes mellitus, however, studies evaluating the relationship between SES and the glycaemic control have shown variable results.Objective and hypotheses: To understand the effect of SES on the long term glycemic control in children with type 1 diaebtes mellitus (T1DM) at a tertiary centre in India.</...

Background: Obesity-related insulin resistance is present in obese children and Matsuda index is a method proposed to evaluate insulin resistance, using data obtained from the oral glucose tolerance test (OGTT).Objective and hypotheses: To investigate whether the clinical indicators of family history of obesity and/or Type II diabetes, acanthosis nigricans, and increased waist circumference are associated with insulin resistance, as calculated by the Mat...

Background: Obesity is a disease (2) which is associated with increased morbidity and mortality rate (3) and needs extensive preventive procedures and effective interferences. Children with obese parent are in danger of becoming obese in their adolescence and adulthood even when trying to keep their weight stable.Objective and hypotheses: We aimed to investigate whether parental obesity can trigger obesity in children or not.Method...

Background: Obesity is a disease which is associated with increased morbidity and mortality rate and needs extensive preventive procedures and effective interferences. Children with obese parent are in danger of becoming obese in their adolescence and adulthood even when trying to keep their weight stable.Objective and hypotheses: We aimed to investigate whether parental obesity can trigger obesity in children or not.Method: This i...

Background: Today the features of GH therapy in children after reaching the beginning of puberty and the necessity of therapy in such age group are discussed.Objective and hypotheses: To identify the relationship between the growth increase after the start of puberty (patient’s bone age achieved 12–13 years, according to the atlas Greulich) and the individual characteristics of the patients.Method: Thirty-four patients wi...