ESPE Abstracts

Background: Blood glucose control in children and adolescents with type 1 diabetes (TD1) is the most important goal in order to reduce potential complications. Following up these patients frequently and recording the relative metabolic parameters on a regular basis is necessary.Objective and hypotheses: The aim of the study was to compare the level of metabolic control in the children and adolescents with TD1 that are followed up in our Pediatric Diabete...

Background: It has already been documented that selenium treatment has beneficial effects in adult patients with autoimmune thyroiditis, especially in those with a higher titer of antibodies and increased inflammatory disease activity.Objective and hypotheses: To investigate whether daily supplementation of organic selenium at a high dose (200 μg in the form of L-selenomethionine) has any effect on the titer of thyroid autoantibodies.<p class="a...

Background: A number of studies have previously described seasonality of birth in children with type 1 diabetes, thus suggesting that the autoimmune process may begin during fetal development. However, there is a lack of data regarding autoimmune thyroid disease in childhood.Objective and hypotheses: The aim of this study was to analyse the seasonal birth month pattern in young patients with Hashimoto thyroiditis and compare it with that of youth healthy...

Background: A positive association between osteoprotegerin (OPG) levels and cardiovascular morbidity and mortality has been recently reported. Additionally, there is evidence that OPG in obese adults participates in the pathogenesis of atherosclerosis and cardiovascular diseases by promoting inflammation, which is known to be linked to insulin resistance (IR). There is few data regarding the relationship among obesity-IR-OPG, in youth.Objective and hypot...

Background: Type 1 diabetes mellitus (T1DM) has been described to be associated with altered oxidative status. Combined analysis of pro-oxidative and anti-oxidative mechanisms in youngsters with T1DM has been less studied.Objective and hypotheses: To evaluate pro-oxidative/anti-oxidative status in T1DM youngsters and healthy controls and investigate their possible association with glycemic control.Method: Sixty-three children and a...

Background: Vitamin D deficiency has been associated with left ventricular geometry and hypertrophy and larger end-systolic diameters and worse left ventricular function in animals and humans.Objective and hypotheses: The aim of this study was to investigate any possible association between vitamin D levels and geometry of left ventricle (LV) in youngsters with type 1 diabetes mellitus (T1DM).Method: 58 youngsters with T1DM with me...

Background: Alterations in DNA methylation status of specific genetic loci may affect gene expression, thus leading to autoimmunopathies.Objective and hypotheses: This study aimed to investigate possible differences in DNA methylation pattern between type 1 diabetes mellitus (T1DM) youngsters and healthy controls.Method: Ten T1DM participants and 10 age-/gender-matched controls were enrolled. DNA was extracted from white blood cell...

Background: Autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy (APECED), is a rare inherited disease of childhood, caused by the mutation of the AIRE gene on chromosome 21. It is characterized by three main diseases: chronic mucocutaneous candidiasis (CMC), chronic hypoparathyroidism (HP), and Addison’s disease (AD), and can be associated with other autoimmune diseases and/or manifestations of ectodermal dystrophy.Case...

Background: Data regarding the prevalence of metabolic syndrome (MS) in Greek adolescents and the effect of school interventions are scarce.Objective and hypotheses: To study the prevalence of MS in a representative sample of Greek adolescents and evaluate the impact of a 6-month educational-behavioral intervention.Method: Cross-sectional anthropometric data ((height, weight, waist circumference (WC)), blood pressure (BP), fasting ...

Background: Endocrine impairments, such as diabetes insipidus (DI), growth hormone deficiency (GHD) and, to a lesser degree, thyroid or cortisol deficiencies, have been reported after traumatic brain injury (TBI) in adults and much less in children both at the acute post-traumatic phase and after a lag period of time. However, no prospective data exist on the endocrine and acute phase protein response to TBI in childhood.Aim/objective: To unravel possibl...