hrp0082p2-d3-307 | Bone (2) | ESPE2014

Suppression of Bone Turnover and its Determinants in Children Receiving Bisphosphonate Therapy

Kyriakou Andreas , McNeilly Jane D , McMillan Martin , Shaikh Guftar M , Mason Avril , Ahmed Syed Faisal

Background: Bisphosphonate therapy (BPT) reduces osteoclast activity and may be associated with adynamic bone turnover. The extent of suppression of bone turnover and its determinants are unclear.Method: Markers of bone metabolism were evaluated in 15 children (9M/6F) undergoing BPT for osteoporosis. The median age at first biochemical assessment was 10.8 years (0.16, 16.3). Serum type I collagen cross-linked C-telopeptide (CTX), alkaline phosphatase (AL...

hrp0082p2-d3-316 | Bone (2) | ESPE2014

Bone Size and Bone Mineral Content in Adolescents and Young Adults with Eating Disorders

Mason Avril , Shepherd Sheila , Oakley Charlotte , Thrower Michelle , Kyriakou Andreas , Shaikh Guftar , Ahmed Syed Faisal

Background: There is growing concern about the impact of eating disorders on the bone heath during adolescence where peak bone mass acquisition is of paramount importance.Method: A total of 85 patients (77F/8M, 75% anorexia nervosa(AN) and 25% atypical eating disorder), median age 15.2 years (range, 10.9–19.8) and median BMI SDS −1.3 (−4.7 to 0.8) attended the bone densitometry service between Jan 2009 and Dec 2013 for total body (TB) an...

hrp0082p2-d1-453 | Growth | ESPE2014

New Reference for Height in Swedish Boys and Girls

Albertsson-Wikland Kerstin , Niklasson Aimon , Gelander Lars , Holmgren Anton , Nierop Andreas F M

Background: The actual Swedish growth references are based on a cohort born 1974.Objective and hypotheses: Due to secular changes there is need for new height references.Method: Material: Height measurements from birth to adult height (AH) in a cohort of healthy, Nordic and born full term 1990, 20.796 from 1647 boys, 19.202 from 1501 girls were used (ALL) and compared to both a subgroup with puberty close to mean (PHV &#17...

hrp0082p2-d2-576 | Sex Development (1) | ESPE2014

The Utility of AMH for Predicting Testosterone Response to hCG Stimulation in Children with Suspected DSD

Kyriakou Andreas , McNeilly Jane D , Shaikh Guftar M , Mason Avril , Shapiro David , Ahmed Syed Faisal

Background: In children undergoing investigation of testicular function the relationship between serum anti-Mullerian hormone (AMH) and the testosterone response to hCG stimulation test (HST) is unclear.Method: 75 children (3F, 72M) with a median age of 1.08 years (range, 0.003, 14.3) were investigated for suspected DSD by AMH on D1 and testosterone on D1 and D4, before and after 3-day HST. Of these children, 27 had an additional prolonged HST. Normal te...

hrp0094p1-157 | Fetal Endocrinology and Multisystem Disorders B | ESPE2021

Endocrine Monitoring and Outcome After Therapy In Childhood Survivors of Central Nervous System Tumours

Gilani Misha , McIntosh Diana , Murphy Dermot , Ronghe Milind , Sastry Jairam , Shaikh M Guftar , Kyriakou Andreas ,

Background: Childhood cancer survivors (CCS) are at increased risk of endocrinopathies; as a consequence of cranial/craniospinal radiotherapy and alkylating agents. Hypothalamic-pituitary dysfunction, thyroid dysfunction and gonadal failure are frequently seen.Aim: To explore the endocrine monitoring following completion of treatment for central nervous system (CNS) tumours within a regional paediatric oncology service.<...

hrp0094p1-162 | Growth B | ESPE2021

Evaluation of growth patterns from the Edinburgh and Gothenburg cohorts by the QEPS model

Holmgren Anton , Niklasson Aimon , Nierop Andreas F.M , Butler Gary , Albertsson-Wikland Kerstin ,

Background: The QEPS-growth-model, developed and validated in GrowUpGothenburg cohorts, used for developing growth references and investigating healthy/pathological growth, lacks external validation from other longitudinal cohorts of healthy individuals.Objective: To investigate if the QEPS-model fits the longitudinal Edinburgh growth study of another design than GrowUpGothenburg cohorts. To compare growth patterns in tw...

hrp0094p2-354 | Pituitary, neuroendocrinology and puberty | ESPE2021

Relation between specific pubertal growth and breast maturation - a longitudinal study in healthy girls

Bergendahl Sophie , Niklasson Aimon , Stefan Aronson A. , Nierop Andreas F.M , Albertsson-Wikland Kerstin , Holmgren Anton ,

Background: Few studies have investigated in detail how the pubertal breast maturation in girls is related to the pubertal growth spurt in a longitudinal setting. The golden standard for assessment of secondary sex characteristics for girls includes breast development (B1-B5)1. The different maturation stages follow the increasing estradiol production from the ovaries also giving rise to the pubertal growth spurt. The QEPS-growth model makes it poss...

hrp0097p1-240 | Diabetes and Insulin | ESPE2023

Age differences in the distribution of diabetes-specific antibodies in children and adolescents with type 1 diabetes mellitus

Schweizer Roland , Mayer David , Bung Julia , Liebrich Franziska , Neu Andreas , Ziegler Julian

Background: The assignment to type 1 diabetes mellitus (T1DM) can be confirmed by the determination of diabetes-specific autoantibodies. Five different antibodies can be determined. The determination of several antibodies is more expensive than the determination of a single antibody. In times of scarce resources, the sequential determination of antibodies could save costs. The aim of this study was to determine the frequency of antibodies and their age and gen...

hrp0097p2-108 | GH and IGFs | ESPE2023

Acromegaly in a 14-year-old girl with pituitary adenoma

Fingerhut Karin , Krebs Andreas , Otfried Schwab Karl , Spiekerkötter Ute , van der Werf Natascha

Introduction: Acromegaly is a rare disorder, developed by overproduction of growth hormone (GH) and insulin-growth factor 1 (IGF-1), in most cases based on a pituitary adenoma. The increased IGF-1 and GH levels lead to the growth of acres and organs as well as metabolic changes. When manifesting before epiphyseal closure, a giant growth develops.Case Report: A Ukrainian girl presented at the age of 14 years with enlargem...

hrp0098p1-191 | Sex Endocrinology and Gonads 2 | ESPE2024

Assessing quality of care for people with differences of sex development (DSD) – results of an annual benchmarking of DSD centres in Germany

Doehnert Ulla , Schnoor Maike , Heidenreich Andreas , Juergensen Martina , Katalinic Alexander , Hiort Olaf

Background: International guidelines recommend specialised medical and psychosocial care for people with DSD by multidisciplinary teams in designated centres. The DSDCare project, funded by the German Federal Ministry of Health from 05/2020-08/2023, aimed to implement a standardised care model for people with DSD, and evaluate quality of care in 10 centres in Germany.Methods: Initially, quality indicators for structural,...