hrp0084p2-265 | Diabetes | ESPE2015

Importance of Thrombocyte Volume Parameters in Type 1 Diabetes Mellitus Patients with and without Clinical Findings of Diabetic Ketoacidosis

Vuralli Dogus , Aksoy Hatice Tatar , Yilmaz Arzu , Engiz Ozlem , Dallar Yildiz Bilge

Background: Thrombocyte volume parameters such as mean thrombocyte volume (MPV) and PDW (thrombocyte distribution volume) are parameters used in evaluation of thrombocyte size which have hemostatic importance. The increased thrombocyte volume is a marker of thrombocyte activation. The thrombocyte activity is important in pathophysiology of diseases with a tendency of thrombosis and inflammation. In adult studies it has been reported that MPV increases in thrombotic diseases su...

hrp0084p2-358 | Fat | ESPE2015

Elevated Serum Irisin Level is not Related to Metabolic and Anthropometric Parameters in Obese Children

Abaci Ayhan , Catli Gonul , Tuhan Hale Unver , Anik Ahmet , Kume Tuncay , Calan Ozlem Gursoy , Bober Ece

Background: Irisin is a newly discovered myokine which regulates energy metabolism and obesity (type 2 diabetes pathogenesis). However, results of the clinical studies investigating the relation of irisin with metabolic and anthropometric parameters remain controversial, and studies in obese children are limited.Objective and hypotheses: We aimed to investigate the relation of serum irisin level with metabolic and anthropometric parameters in obese child...

hrp0084p2-527 | Puberty | ESPE2015

Evaluation of Final Height in Girls Taking GnRH Analogue: Should the Age Limit for Precocious Puberty be Changed?

Vuralli Dogus , Dallar Yildiz Bilge , Tapci Esra , Engiz Ozlem , Simsek Enver

Background: The age limit for precocious puberty (PP) in girls is a topic that continues to be debated, and there is a new trend that supports the idea that the beginning of breast development in girls between ages 6 and 8 should not be accepted as true PP and it is necessary to label this clinical condition as accelerated puberty or early normal puberty.Objective and hypotheses: The aim of the current study is to determine the diagnostic criteria for gi...

hrp0084p3-640 | Bone | ESPE2015

Cranial MR Spectrometry Findings of Patients Aged 10–15 Years with Diagnosis of Rickets

Dogan Murat , Aydin Ilyas , Bala Keziban Asli , Kaba Sultan , Gulpinar Ozlem

Objective: It is known that vitamin D has differential roles in cell proliferation, differentiation, neurotransmission and neuroplasticity in nervous system and exerts neurotrophic and neuroprotective effects, even different functions of vitamin D has been studied by advocating that vitamin D should be classified as a neurosteroid. It has been long known that vitamin D deficiency, VDR dysfunction, hyperparathyroidism and hypervitaminosis are potential causes for sensorineural ...

hrp0084p3-645 | Bone | ESPE2015

Long Term Effects of Bisphosphonate Treatment in a Case with Infantile Onset Severe form of Juvenile Paget’s Disease

Gonc E Nazli , Ozon Z Alev , Buyukyilmaz Gonul , Alikasifoglu Ayfer , Simsek Ozlem , Kandemir Nurgun

Background: Juvenile Paget’s disease is a rare autosomal recessive osteopathy. Patients presenting in infancy develop severe bone deformities and may never walk. Bisphosphonate therapy is used to decrease bone turnover and it has generally good responses in milder forms of the disease. However there is no long-term experience of bisphosphonates in severe infantile forms.Case report: A 9 month-old boy was referred to our clinic for bone deformities. ...

hrp0084p3-758 | Diabetes | ESPE2015

A Case of Tacrolimus Related Posttranslated Diabetes Mellitus (PTDM)

Keskin Mehmet , Karaoglan Murat , Kara Mehtap Akbalik , Buyukcelik Mithat , Keskin Ozlem

Background: Tacrolimus is highly potent immunosuppressant agent. Despite it is quite prophylactic effect on renal allogreft rejection, the most marked side effect of tacrolimus is lead to posttranslated diabetes mellitus. There are some predictive risk factors which are determined on development of tacrolimus related diabetes mellitus: Advanced age, familial history, genetic factors, ethnicity, impaired glucose tolerance or metabolic syndrome in pre-transplantation period, obe...

hrp0084p3-855 | Fat | ESPE2015

Plasminogen Activator Inhibitor-1 as a Marker of Insulin Resistance in Obese Adolescents

Engiz Ozlem , Alioglu Bulent , Bagrul Denizhan , Karakaya Jale , Dallar Yildiz Bilge

Background: Obesity is considered to be a chronic inflammatory state in which the dysfunction of adipose tissue plays a central role. Adipose tissue is known to express and secrete a variety of products known as ‘adipokines’ including leptin, adiponectin, resistin, and visfatin, as well as cytokines and chemokines such as tumor necrosis factor-α (TNF-α), interleukin-6, and monocyte chemoattractant protein-1.Objective and hypotheses: T...

hrp0098p1-302 | Late Breaking 1 | ESPE2024

Evaluation of Copeptin Level in Children and Adolescents Monitored with Central Diabetes Incipidus

Manav Mustafa , Ozsu Elif , Dogan Ozlem , Siklar Zeynep , Kizilcan Cetin Sirmen , Aycan Zehra , Berberoglu Merih

Background: Polyuria-polydipsia syndrome (PPS) is a common condition in children, and its etiology is not always easily elucidated. Although the water deprivation test remains the gold standard for diagnosis, its limitations necessitate the search for alternative diagnostic methods. Due to its stability, copeptin is a valuable current parameter that is considered more reliable than AVP measurement. This study aims to compare copeptin levels between patients wi...

hrp0098p2-51 | Bone, Growth Plate and Mineral Metabolism | ESPE2024

Real-world experience with vosoritide treatment in achondroplasia: A single-center report from Turkey

Abali Saygin , Sebnem Ozkose Gulsah , Akgun-Dogan Ozlem , Semiz Serap , Alanay Yasemin

Introduction: Vosoritide, a C-type natriuretic peptide analog, has emerged as the first therapeutic agent approved to enhance growth velocity in individuals with achondroplasia (ACH).Aim: To assess growth response to vosoritide in children with ACH under the care of a specialized multidisciplinary team (MDT).Methods: A retrospective study was conducted in our center on children dia...

hrp0098p2-300 | Late Breaking | ESPE2024

Comparison of Steroid Hormone Levels Measured by Immunoassay and Liquid Chromatography-Mass Spectrometry (LC-MS) Methods in the Follow-Up of Patients with Congenital Adrenal Hyperplasia

Taba-Tabai Shahla , Ozsu Elif , Siklar Zeynep , Kizilcan Cetin Sirmen , Dogan Ozlem , Aycan Zehra , Berberoglu Merih

Background: Congenital adrenal hyperplasia (CAH) is an autosomal recessive inherited disorder resulting from a genetic defect in one of the enzymes involved in the synthesis of cortisol from cholesterol in the adrenal cortex. Although steroid hormone levels are used in the diagnosis and monitoring of CAH, not all steroid hormone levels can be measured by ELISA. Steroid hormone levels are measured using immunoassay and liquid chromatography-mass spectrometry (L...