hrp0086p1-p247 | Diabetes P1 | ESPE2016

Which is the Best Site for Catheter Placement in Young Children with Type 1 Diabetes (T1D) and CSII?

Xatzipsalti Maria , Vakaki Marina , Patouni Konstantina , Kourti Afroditi , Mentesidou Lida , Choundala Anna , Stamoyannou Lela , Vazeou Andriani

Background: Few data exist for young children regarding the proper site for insulin catheter insertion for pump (CSII) users.Objective and hypotheses: To evaluate the proper site for catheter insertion in very young children (<8 year old) with T1D and CSII.Method: The study comprised 10 children [7 females, median age 4.43 years (range 2.3–7.18), median disease duration 1.65 years] with T1D who were on CSII. Ultrasound mea...

hrp0086p2-p321 | Diabetes P2 | ESPE2016

Achievement of Metabolic Parameter Goals in Children and Adolescent with Type 1 Diabetes According to the Latest ADA/ISPAD Standards of Medical Care in Diabetes in a Pediatric Diabetes Clinic in North Greece

Papagianni Maria , Vamvakis Anastasios , Tsiroukidou Kiriaki , Kosta Konstantina , Mameka Iliana , Chatzakis Christos , Grenda Efthimia , Tsanakas Ioannis

Background: Blood glucose control in children and adolescents with type 1 diabetes (TD1) is the most important goal in order to reduce potential complications. Following up these patients frequently and recording the relative metabolic parameters on a regular basis is necessary.Objective and hypotheses: The aim of the study was to compare the level of metabolic control in the children and adolescents with TD1 that are followed up in our Pediatric Diabete...

hrp0086p2-p790 | Pituitary and Neuroendocrinology P2 | ESPE2016

Precocious Puberty in a Girl With Prader Willi Syndrome

Papagianni Maria , Kosta Konstantina , Lialias Ioannis , Chatzakis Christos , Tsiroukidou Kiriaki , Tsanakas Ioannis

Background: Prader Willi Syndrome (PWS) is a rare genetic disorder with a wide range of symptoms manifestation. Main characteristics are hypotonia, growth retardation, feeding difficulties in neonatal period, increased appetite and obesity in childhood, delayed puberty or hypogonadism in adolescence. It is also associated with behavioral disturbances and impaired cognitive function. The genetic defect is located on the 15q11-13 chromosome.Objective and h...

hrp0086p1-p925 | Thyroid P1 | ESPE2016

L-selenomethionine Supplementation in Children and Adolescents with Autoimmune Thyroiditis: Preliminary Results of a Randomized Double-blinded Placebo-controlled Clinical Trial

Kyrgios Ioannis , Dimopoulou Aikaterini , Kotanidou Eleni , Kleisarchaki Angeliki , Mouzaki Konstantina , Galli-Tsinopoulou Assimina

Background: It has already been documented that selenium treatment has beneficial effects in adult patients with autoimmune thyroiditis, especially in those with a higher titer of antibodies and increased inflammatory disease activity.Objective and hypotheses: To investigate whether daily supplementation of organic selenium at a high dose (200 μg in the form of L-selenomethionine) has any effect on the titer of thyroid autoantibodies.<p class="a...

hrp0082lbp-d3-1014 | (1) | ESPE2014

CpG Methylation Changes within the INS, HLA-G and PTPN-22 Promoters in Childhood Type 1 Diabetes

Kyrgios Ioannis , Mouzaki Konstantina , Spandonidis Theodoros , Fragou Aikaterini , Tzimagiorgis Georgios , Eboriadou-Petikopoulou Maria , Galli-Tsinopoulou Assimina

Background: Alterations in DNA methylation status of specific genetic loci may affect gene expression, thus leading to autoimmunopathies.Objective and hypotheses: This study aimed to investigate possible differences in DNA methylation pattern between type 1 diabetes mellitus (T1DM) youngsters and healthy controls.Method: Ten T1DM participants and 10 age-/gender-matched controls were enrolled. DNA was extracted from white blood cell...

hrp0097p1-218 | Bone, Growth Plate and Mineral Metabolism | ESPE2023

Osteoporosis pseudoglioma syndrome: a case report of a child with osteoporosis and impaired vision

Iordanidou Aikaterini , Toulia Ilektra , Adamidou Fotini , Kosta Konstantina , Papadopoulou Anna , Roilides Emmanouel , Papagianni Maria

Introduction: Osteoporosis pseudoglioma syndrome (OPPG) is a rare autosomal recessive disease which is caused by mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene and is characterized by severe early – onset osteoporosis and vitreoretinal complications leading to blindness by young adulthood.Case presentation: We present a case of an 8 years old boy, who was initially referred to our d...

hrp0089lb-p4 | Late Breaking P1 | ESPE2018

An Updated Evolutionary Study in Glucocorticoid Receptors; Insights from a Comprehensive Phylogenetic, SNP’s and Mutation’s Analysis of the Nuclear Receptors Family: An Updated Evolutionary Study in Glucocorticoid Receptors; Insights from a Comprehensive Phylogenetic, SNP’s and Mutation’s Analysis of the Nuclear Receptors Family

Papageorgiou Louis , Papakonstantinou Eleni , Salis Constantinos , Raftopoulou Sofia , Mitsis Thanasis , Nicolaides Nicolas , Hagidimitriou Marianna , Eliopoulos Elias , Charmandari Evangelia , Chrousos George , Vlachakis Dimitrios

Background: Protein subfamilies within the Nuclear receptor (NR) family share common domain architecture. These closely related receptors and their cognate ligand compounds play a key role in homeostasis, reproduction, growth, and development. Despite their biological significance, their evolution and diversification remains to be elucidated. SNPs and mutations are characterized by the permanent alteration of the nucleotide sequence in the genome of an organism. These alterati...

hrp0092p3-96 | Fat, Metabolism and Obesity | ESPE2019

Assessment of Cardiac Function in Obese Children and Adolescents with Metabolic Syndrome

Tragomalou Athanasia , Kosti Evangelia , Sveroni Konstantina , Loukopoulou Sofia , Binou Maria , Kourlaba Georgia , Papadopoulou Marina , Kassari Penio , Charmandari Evangelia

Background: Obesity in childhood and adolescence is often associated with dyslipidemia, hypertension, insulin resistance, inflammation, and disturbances in adipocytokine secretion, which lead to endothelial dysfunction and the development of atherosclerotic cardiovascular disease.Aim: To determine the prevalence of metabolic syndrome (MS) among obese children and adolescents attending our out-patient childhood obesity cl...

hrp0089fc1.5 | Adrenals &amp; HPA Axis | ESPE2018

Untargeted Plasma Metabolomics in Subjects with Differences in Tissue Glucocorticoid Sensitivity Identifies a Novel metabolic Signature

Nicolaides Nicolas C. , Ioannidi Maria-Konstantina , Koniari Eleni , Sertedaki Amalia , Klapa Maria I. , Chrousos George P. , Charmandari Evangelia

Background: Tissue glucocorticoid sensitivity is characterized by a considerable variation in terms of therapeutic response and side effects to synthetic glucocorticoids. The multi-metabolite concentration profile measured by untargeted plasma metabolomics provides a comprehensive metabolic signature that might be used in clinical practice.Objective and Hypotheses: To investigate the usefulness of plasma metabolomics in identifying a metabolic signature ...

hrp0089p1-p054 | Diabetes &amp; Insulin P1 | ESPE2018

CpG Methylation Status Changes within the Protein Tyrosine Phosphatase Non-Receptor Type 22 Gene Promoters in Children and Adolescents of Greek Origin with Type 1 Diabetes

Mouzaki Konstantina , Giza Styliani , Kotanidou Eleni P. , Fragou Aikaterini , Taousani Maria , Eboriadou-Petikopoulou Maria , Tzimagiorgis Georgios , Galli-Tsinopoulou Assimina

Introduction: Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a well-established genetic locus of type 1 diabetes (T1D). The aim of the present study is to compare the methylation level of PTPN22 between children and adolescents of Greek origin with T1D and healthy controls.Patients and Methods: Twenty T1D participants and 20 age-/gender-matched healthy youngsters were enrolled. DNA was extracted from white blood cells, the...