hrp0092p2-246 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2019

Comparison of Growth Status, Level of Blood Glucose and Lipid Metabolism in SGA and AGA Girls with Central Precocious Puberty

Yang Xi , Yu Xiao , Zhao Yue , Luo Xiaoping , Liang Yan , Wu Wei , Ying Yanqin , Hou Ling

Background: Several studies have shown that born small for gestational age (SGA) children have earlier precocious puberty, progress faster, and are less likely to gain target height in adults than children born appropriate for gestational age (AGA). Moreover, SGA children are more prone to metabolic disorders - obesity, diabetes and cardiovascular disease.Objective: To compare the physical development status, serum lipid...

hrp0092p3-12 | Adrenals and HPA Axis | ESPE2019

Clinical Follow-Up of a Novel NR0B1 Mutation in a Case of Adrenal Hypoplasia Congenital

yang haihua , wei haiyan , Shen Linghua , Wang Huizhen , Chen Qiong , Chen Yongxing , Liu Xiaojing

We have examined a male child patient aged about 15 years old to confirm the diagnosis of adrenal hypoplasia congenital (AHC) at the Genetics in-patient department, Children's Hospital Affiliated to Zhengzhou University.When the child was 5 years and 9 months,he was diagnosed as abmormal phenotypic characteristics who had skin hyperpigmentation, penis enlargement, rapid growth over the past 2 years, along with fatigue, drowsiness, and pubic hair appearing for 2 months.Base...

hrp0092p3-305 | Late Breaking Abstracts | ESPE2019

Combined Surgical and Medical Treatment in an Adolescent with Severe Gynecomastia Due to Excessive Estradiol Secretion: A Case Report

Lee Miseon , Moon JungEun , Woo Ko Cheol , Seok Lee Joon , Dug Yang Jung

Background: Gynecomastia develops due to the reversed estradiol-to-Testosterone ratio in adolescence, and symptoms typically improve within two years. The causes vary widely, including estrogen excess and tumors, and surgical treatment is usually given in late adolescence because postoperative symptoms may recur in adolescents. There are no guiding recommendations for gynecomastia to date besides the suggestion to consider rapidly growing gynecomastia and brea...

hrp0089p1-p102 | Fat, Metabolism and Obesity P1 | ESPE2018

Plasma Adropin Levels are Associated with Lipid Characteristics Amongst Children with Obesity

Chen Ruimin , Yuan Xin , Ouyang Qian , Ai Zhuanzhuan , Lin Xiangquan , Zhang Ying , Yang Xiaohong , Cai Chunyan

Objective: This study is to evaluate the association among plasma adropin, leptin, lipopolysaccharide-binding protein (LBP) levels and lipid characteristics in children with obesity.Methods: This was a cross-sectional study of children with obesity ranging from 5.5 to 12.5 years old, and age- and gender-matched children with normal weight were collected as control. Height, weight, waist circumference and hip circumference of all the participants were mea...

hrp0089p1-p103 | Fat, Metabolism and Obesity P1 | ESPE2018

Associations of Non-High-Density Lipoprotein Cholesterol with Metabolic Syndrome and Its Components in Korean Children and Adolescents: the Korea National Health and Nutrition Examination Surveys 2008–2014

Shim Young Suk , Jeong Hwal Rim , Yang Seung , Kim Eun Young , Hwang Il Tae

Background: In this study, we aimed to investigate the relationship between single-gender Korean references for non-high-density-lipoprotein cholesterol (non-HDL-C) and metabolic syndrome (MetS) in childhood.Methods: A total of 5,742 Korean children aged 10–18 years who participated in a national survey were included. The subjects were classified into three groups based on single-gender non-HDL-C levels as follows: <120 mg/dl (desirable), &#8805...

hrp0089p2-p169 | Fat, Metabolism and Obesity P2 | ESPE2018

Relationship between Glucose and Lipid Metabolism, Inflammatory Factors and Adipokines in Children with Obesity

Chen Ruimin , Ouyang Qian , Yuan Xin , Ai Zhuanzhuan , Cai Chunyan , Lin Xiangquan , Zhang Ying , Yang Xiaohong

Objective: To investigate the co-relationship among glucolipid metabolism and inflammation, adipokines in obese and normal weight children.Methods: Children aged 5 to 15 year-old were collected. Fasting venous blood samples were collected to test liver function, triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), fasting plasma glucose (FPG) and insulin. The inflammatory marker...

hrp0089p3-p218 | GH &amp; IGFs P3 | ESPE2018

Bone Age Maturation During the Three Years of GH Treatment in Patients with Idiopathic GH Deficiency and Idiopathic Short Stature: Analysis of Data from LG Growth Study

Shim Young Suk , Hwang Il Tae , Yang Seung , Kim Eun Young

Background: Although the beneficial effects of GH treatment on statural growth are well known, the impacts on skeletal maturation are not fully understood. In the current study, we aimed to investigate the progression of bone age (BA) in children with idiopathic GH deficiency (iGHD) and idiopathic short stature (ISS) based on a LG Growth Study (LGS). We also evaluated the progression rate of BA relative to chronologic age (CA) between iGHD and ISS and to find their associated ...

hrp0089p1-p207 | Pituitary, Neuroendocrinology and Puberty P1 | ESPE2018

Urinary Gonadotropins as a Useful Non-invasive Marker of Central Precocious Puberty

Hwang Il Tae , Jeong Hwal Rim , Yang Seung , Shim Young Suk

Aims: The current study aimed that first morning voided (FMV) urinary gonadotropin measurements could be used as a noninvasive alternative to the gonadotropin-releasing hormone (GnRH) test in the assessment of the hypothalamic-pituitary-gonadal function in children.Methods: In a multi-center study, we compared FMV urinary gonadotropin concentrations with GnRH-stimulated serum gonadotropin levels in 140 girls aged 7–9 years who were evaluated for pub...

hrp0086p2-p707 | Endocrinology and Multisystemic Diseases P2 | ESPE2016

The Triglyceride to High-Density Lipoprotein Cholesterol Ratio and Non-High-Density Lipoprotein Cholesterol Reference Data for Korean Children and Adolescents: Results of the 2007–2013 Korean National Health and Nutrition Examination Surveys (KHANES)

Kang Min Jae , Baek Joon Woo , Oh Yeon Joung , Hwang Il Tae , Yang Seung

Background: Cholesterol levels are variable throughout childhood and adolescence. The attention not only to conventional lipid profiles but also to non-high-density lipoprotein cholesterol (non-HDL-C) and triglyceride to HDL-C ratio (TG/HDL-C ratio) are becoming more apparent in pediatric lipid studies because of their clinical importance.Objective and hypotheses: The aim of the present study was to establish age- and gender-specific reference values for...

hrp0086p1-p727 | Pituitary and Neuroendocrinology P1 | ESPE2016

Changes of Serum AMH and Inhibin B Levels in Girls with Central Precocious Puberty before and During Treatment with GnRH Agonists

Oh Yeon Joung , Baek Joon Woo , Kang Min Jae , Yang Seung , Hwang Il Tae

Background: In girls with central precious puberty (CPP), the hypothalamic-pituitary-gonadal axis is prematurely activated. If the girl is treated with GnRH agonist (GnRH-a), gonadotropins levels become suppressed.Objective and hypotheses: We aimed to evaluate whether serum antimu llerian hormone (AMH) and inhibin B levels are affected in girls with CPP and whether pituitary suppression by GnRH-a affects serum AMH and inhibin B levels.<p class="abste...