ESPE Abstracts

Introduction: Congenital Hypothyroidism if not treated timely presents with growth & developmental delay. Thyroid hormones and Growth hormone- Insulin like growth factor 1 axis (GH-IGF-1) together are critical for somatic and skeletal growth. Hypothyroidism and derangement in this axis leads to profound growth retardation and delayed skeletal maturation. Limited studies suggest that thyroxine directly regulates IGF-1 independent of GH in congenital hypothyroidism.<p cl...

Background: Children with septo-optic dysplasia (SOD) and related disorders can present with either hypogonadotropic hypogonadism or precocious puberty. This phenotypic variability remains unexplained.Objective and hypotheses: To compare pubertal characteristics of SOD with isolated congenital hypopituitarism (CPHD) and optic nerve hypoplasia (ONH).Method: Retrospective longitudinal data collection from 259 patients with: SOD (...

Introduction: Septo-optic dysplasia (SOD) is characterized by a combination of midline forebrain, pituitary and eye abnormalities. We aimed to evaluate endocrine features of patients with SOD, and multiple pituitary hormone deficiencies (MPHD).Design: Retrospective data were collected from 130 patients: 102 SOD and 28 MPHD followed at a single tertiary centre. SOD were divided into two groups: with pituitary hormone deficiencies (SOD+, n=83) and...

Background: Third generation aromatase inhibitors have been used to increase predicted adult height (PAH) in boys but in girls only in McCune–Albright syndrome.Objective and hypotheses: We overcame the theoretical concern of secondary hyperandrogenism by combining anastrazole to an LHRH analogue in a 6-year prospective study to test whether the combination therapy could significantly improve PAH compared to inhibition of puberty alone.<p class="...

Background: Strong association of early postnatal catchup growth in SGA with higher leptin levels and increased risk of insulin resistance has been described.Objective: To determine leptin levels in term small for gestational age (SGA) children at 15–18 months age and assess their relationship with postnatal catchup growth (CUG).Methods: Birth and current weight and length of 60 term SGA (<10thpercentile) childr...

Background: Small for gestational age (SGA) children, especially those with postnatal catchup growth, have increased risk of insulin resistance and adult metabolic diseases. Adipokines produced by adipose tissue play crucial role in fetal growth and early postnatal life. Low adiponectin (adipokine) is marker of insulin resistance.Objective: To evaluate adiponectin levels in term SGA at 15–18 months age and its relationship with postnatal catchup gro...

Background: Obese children are known to be at high risk for vascular complications and there is paucity in Indian literature regarding the onset and magnitude of vascular complications. Carotid intima media thickness (cIMT) and Brachial artery distensibility are known to predict future atherogenesis.Objective and hypotheses: To compare vascular parameters of obese children aged 5–18 years with age and sex matched controls and its relationship with p...

Background: Childhood obesity associated with risk of developing metabolic syndrome (MetS) and paucity in Indian literature regarding correlation between clinical and biochemical parameters in obese and MetS.Objective and hypotheses: Comparing clinical and biochemical correlation of obese children, controls and MetS.Method: Eighty children (40 obese and 40 age and sex matched controls) 5–18 years recruited after approval by In...

Background: Recently, T3 receptor alpha (TRα) mutations have been identified in a number of patients with varying degrees of growth impairment, delayed development, constipation, increases in serum T3 and decreases in T4 and rT3.Objective: To determine the spectrum of clinical and functional consequences of novel TRα mutations.Method: Clinical assessment and biochemical, imaging...

Background: Congenital adrenal hyperplasia (CAH) due to 11β-hydroxylase deficiency (11OHD), a rare autosomal recessive disorder, is the second most common form of CAH, resulting in glucocorticoid deficiency, hyperandrogenism and hypertension.Objective and hypotheses: To investigate the specific CAH mutations in CYP11B1 gene and to examine for genotype-phenotype correlations.Method: 21 patients (n=9, 46, XX; <...