hrp0084p1-112 | Puberty | ESPE2015

Aetiological Spectrum and Clinical Characteristics of 129 Children with Gonadotropin Independent Precocious Puberty: A Nationwide Cohort Study

Atay Zeynep , Yesilkaya Ediz , Erdeve Senay Savas , Akin Leyla , Eren Erdal , Doger Esra , Aycan Zehra , Abali Zehra Yavas , Akinci Aysehan , Siklar Zeynep , Ozen Samim , Kara Cengiz , Tayfun Meltem , Tutunculer Filiz , Karabulut Gulcan Seymen , Karaguzel Gulay , Saglam Halil , Bideci Aysun , Kurtoglu Selim , Bereket Abdullah , Turan Serap , Sari Erkan , Cetinkaya Semra , Guran Tulay

Background: Gonadotropin independent precocious puberty (GIPP) is caused by a heterogenous group of disorders. With the exception of congenital adrenal hyperplasia (CAH), disorders causing GIPP are uncommon, and there are no studies evaluating the etiologic distribution of GIPP in a large cohort.Objective and hypotheses: To find out the relative frequencies of each etiological group in patients with non-CAH GIPP and also to evaluate the clinical and labo...

hrp0084p3-1017 | Growth | ESPE2015

The Growth Characteristics of Patients with Noonan Syndrome, and First 2 Years Results of GH Treatment: A Nationwide Multicentre Study

Siklar Zeynep , Berberoglu Merih , Genens Mikayir , Poyrazoglu Sukran , Bas Firdevs , Darendeliler Feyza , Bundak Ruveyde , Aycan Zehra , Erdeve Senay Savas , Cetinkaya Semra , Abali Saygin , Atay Zeynep , Turan Serap , Kara Cengiz , Yilmaz Gulay Can , Akyurek Nesibe , Abaci Ayhan , Sari Erkan , Yesilkaya Ediz , Bolu Semih , Korkmaz Huseyin Anil , Simsek Enver , Catli Gonul , Cayir Atilla , Evliyaglu Olcay , Isguven Sukriye Pinar

Introduction: Short stature is a common manifestation of Noonan syndrome (NS). GH deficiency, GH insensitivity, and neurosecretory dysfunction have been reported in the literature. The optimal GH treatment for NS is still controversial. In this study, we aimed to evaluate the growth characteristics in addition to clinical features of NS, and the growth response to GH treatment by using a nationwide registration system.Material and methods: Children and a...

hrp0095p1-546 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Change of menarcheal age in schoolgirls living in Istanbul over the last 12 years

Guran Tulay , Alir Fahriye , Taha Arslan Yusuf , Molla Giasim , Sahin Berk , Emir Sayar Mehmet , Atay Zeynep , Helvacioglu Didem , Gurpinar Tosun Busra , Haliloglu Belma , Turan Serap , Hidiroglu Seyhan , Bereket Abdullah

Background: Menarche is the endpoint of a complex sequence of maturational events but is the unique marker of female puberty. Timing of menarche is a strongly heritable trait. However, secular trends suggest that lifestyle and/or environmental factors are important.Objective: To assess the trend in age at menarche (AAM) in Istanbul over the last 12 years, and compare the patterns according to socioeconomic status (SES), ...

hrp0095p2-218 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Evaluation of The Effects of Carob (Ceratonia Siliqua L.) Fruits on the Puberty of Rats

Kılınç Uğurlu Aylin , Bideci Aysun , Anadol Elvan , Süntar İpek , Take Kaplanoğlu Gülnur , Gülbahar Özlem , Şafak Teksin Zeynep , Dayanır Duygu , Saadet Deveci Bulut Tuba , Uluoğlu Canan , Çamurdan M.Orhun

Introduction: Ceratonia siliqua L. (CS) is from the legumes (Fabaceae) family, and different forms such as carob extract and flour are preferred by parents because it is a natural sweetener and a source of vegetable carbohydrates. CS is rich in polyphenols and flavonoids. When we questioned histories of the cases of early puberty and puberty variants who applied to our clinic, we noticed long-term and regular use in some cases. We planned to experimen...

hrp0092p1-273 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology (1) | ESPE2019

Hypergonadotropic Hypogonadism in 46, XX Adolescents Without Gonadotoxic Therapy: Clinical Features and Molecular Etiologies

Abali Zehra Yavas , Jolly Angad , Guran Tulay , Bayram Yavuz , Abali Saygin , Bas Serpil , Akdemir Zeynep Coban , Posey Jennifer Ellen , Helvacioglu Didem , Kirkgoz Tarik , Eltan Mehmet , Kaygusuz Sare Betul , Lupski James R , Bereket Abdullah , Turan Serap

Background: Hypergonadotropic hypogonadism(HH) in females results from primary gonadal failure related to genetic defects affecting ovarian development and function or acquired gonadal damage; limited knowledge exist regarding underlying genes involved or potential gene X environment interactions responsible for disease trait manifestations. While pathogenic variants in single genes, chromosomal abnormalities such as Turner syndrome and acquired gonadal damage...

hrp0092p3-263 | Thyroid | ESPE2019

Papillary Thyroid Cancer in Children: Single Center Results

Hatipoğlu Nihal , Direk Gül , Uzan Tatli Zeynep , Gül Şiraz Ülkü , Çiçek Dilek , Gök Ebru , Sarikaya Emre , Kendirci Mustafa , Kurtoğlu Selim

Introduction: Thyroid cancers are rare cancers in children and their incidence is 1.4% in pediatric malignancies. However, its frequency is increasing. While the incidence of prepubertal children is equal among girls boys, it increases with age in female patients. Radiotherapy, which is applied to the neck region, and hashimoto disease are the risk factors. The relationship between Hashimoto's disease and papillary thyroid cancer is thought to be assoc...

hrp0089p2-p177 | Fat, Metabolism and Obesity P2 | ESPE2018

The Effects of the Birth Weight on the Fat Distribution and Fatness Parameters of the Body

Hatipoğlu Nihal , Direk Gul , Hepokur Merve Nur , Tatlı Zeynep Uzan , Cicek Betul , Unalan Demet , Mazıcıoğlu M. Mumtaz , Ozturk Ahmet , Kurtoğlu Selim

The weight of birth affects the weight status and fat distribution in the later period of life. It is suggested that both low and high birth weight pose a risk for cardiometabolic diseases. In this study, the effects of birth weight on body fat mass and body fat distribution parameters during childhood and adolescence period were evaluated.Method: In this cross-sectional study, 4581 children ages between 6-17 years at primary and secon...

hrp0084p3-642 | Bone | ESPE2015

Comparison of Treatment Alternatives for Hypercalcemia due to Vitamin D Intoxication in Children

Demir Korcan , Doneray Hakan , Yesilkaya Ediz , Kara Cengiz , Atay Zeynep , Cetinkaya Semra , Cayir Atilla , Anik Ahmet , Eren Erdal , Demirel Fatma , Yilmaz Gulay Can , Ergur Ayca Torel , Kendirci Mustafa , Aycan Zehra , Bereket Abdullah , Aydin Murat , Orbak Zerrin , Ozkan Behzat

Background: No large study comparing efficiency of prednisolone, alendronate and pamidronate has been conducted so far in children with hypercalcemia due to vitamin D intoxication.Objective and hypotheses: To perform a multicentre, retrospective study assessing clinical characteristics and treatment results.Method: A standard questionnaire was uploaded to an online national database system (www.favorsci.org) to collect data of chil...

hrp0098fc12.2 | Thyroid | ESPE2024

Molecular Characterization of Childhood Thyroid Nodules and Thyroid Cancer with DNA/RNA Next Generation Sequencing and Investigation of Phenotype-Genotype Correlation

Aycan Zehra , Kızılcan Çetin Sirmen , Karadağ Kıvrak Hale , Ceyhan Koray , Şıklar Zeynep , Berberoğlu Merih , Özsu Elif , Suat Fitöz Ömer , Dizbay Sak Serpil

Background: Our study aimed to determine the molecular characterization of thyroid nodules and cancer in childhood and investigate the genotype-phenotype relationship.Methods: The pre-postoperative clinical follow-up features and genetic characteristics of 62 patients were evaluated. Next-generation sequencing (NGS) was used to investigate common variants in thyroid lesions with sufficient tissue in the pathology archive...

hrp0089p3-p011 | Adrenals and HPA Axis P3 | ESPE2018

Severe Hyponatraemia with Absence of Hyperkalaemia in a Patient with Addison’s Disease

Doneray Hakan , Ozden Ayse , Kizilelma Nagihan Erol

Objective: Autoimmunity of the adrenal gland, also known as Addison’s disease, is characterised by cell mediated immune destruction of the adrenal cortex. We present a child with Addison’s disease who has severe hyponatraemia and normokalemia, which led to an inappropriately low index of suspicion initially at presentation.Case: A 12-year-old boy diagnosed with adrenal deficiency was admitted to hospital with 2 weeks of vomiting, fatigue and we...