hrp0084wg6.4 | Turner Syndrome | ESPE2015

Management of Middle Ear and Hearing Problems in Turner Syndrome – How Can We Do Better?

Lim David , Donaldson Malcolm , Gault Emma Jane , Clement Andrew , Kubba Haytham , Mason Avril

Background: Otological problems in Turner syndrome (TS) are notoriously common and troublesome, often requiring intervention with adeno-tonsillectomy, insertion of ventilation tubes and occasionally resulting in serious disease such as cholesteatoma.Survey of otological problems in the West of Scotland: A case note review of 174 girls attending the Turner clinic in Glasgow, Scotland from 1989–2015 found that of 155 patients in whom data were availab...

hrp0084p3-935 | GH & IGF | ESPE2015

Do IGF1 Generation Test Results Predict 1st-Year Growth Response to GH Treatment in Idiopathic Short Stature?

Masoom Mohammad Ajmal , Ercan Oya , Bucak Feride Tahmiscioglu , Ozcabi Bahar Taskin , Evliyaoglu Olcay

Background: It is well-known that human GH (hGH) treatment increases growth rate in idiopathic short stature (ISS) in the short term which might predict the overall height gain. However,the fact that ISS might involve a heterogeneous group of individuals with individual benefits from hGH treatment makes the decision to treat or not to treat difficult.Objective and hypotheses: The aim of this study was to investigate retrospectively whether an IGF1 genera...

hrp0094p1-2 | Adrenal A | ESPE2021

Adrenocortical hormone profiles do not predict the molecular etiology in non-CAH primary adrenal insufficiency

Seven Menevse Tuba , Demirkol Yasemin Kendir , Tosun Busra Gurpinar , Bayramoglu Elvan , Yildiz Melek , Acar Sezer , Karaca Seda Erisen , Orbak Zerrin , Onder Asan , Sobu Elif , Anik Ahmet , Atay Zeynep , Bugrul Fuat , Demir Korcan , Dogan Durmus , Emeksiz Hamdi Cihan , Kirmizibekmez Heves , Murat Nurhan Ozcan , Yaman Akan , Turan Serap , Bereket Abdullah , Guran Tulay ,

Background: Primary adrenal insufficiency other than congenital adrenal hyperplasia (non-CAH PAI) is very uncommon in children but associated with a variety of molecular defects. Biosynthesis of adrenocortical hormones is reduced although the relation of steroid profiles with underlying molecular etiology is not yet studied.Objective: Investigation of clinical and steroid hormone profiles of a multicenter cohort of child...

hrp0094p2-2 | Adrenals and HPA Axis | ESPE2021

How do urine steroid metabolites of spot samples correlate with 24 hour urine specimens in children with congenital adrenal hyperplasia?

Sommer Grit , Abawi Ozair , Groessl Michael , Halbsguth Ulrike , Charmandari Evangelia , Akker Erika L.T. van den , Fluck Christa E. ,

Introduction: Steroid profiling in children with congenital adrenal hyperplasia (CAH) is used to monitor the balance between androgen and cortisol metabolites and to decide on the optimal glucocorticoid dosage. Twenty-four hour collection is the gold standard for measurement of steroid metabolites in urine, because steroid production follows a circadian rhythm and is influenced by short-term stress and steroid drugs. For some children, e.g. those who were diap...

hrp0097p1-356 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Acquired Hypothalamic dysfunction in childhood: “What do patients need?“ – an Endo-ERN survey

van Roessel I.M.A.A. , de Graaf J.P. , Biermasz N.R. , Charmandari E. , van Santen H.M.

Objective: Hypothalamic dysfunction is a rare condition and can be encountered in patients who have been diagnosed or treated for a suprasellar brain tumor. Due to its rarity, signs and symptoms of hypothalamic dysfunction may be difficult to recognize, leading to delayed diagnosis of the suprasellar brain tumor or to difficulties in finding the health care expertise for hypothalamic dysfunction after tumor treatment. To improve care and outcome of patients wi...

hrp0097p1-558 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Do perinatal history and mode of delivery affect age at menarche? Preliminary data of girls with Greek origin

Tsinopoulou Vasiliki-Rengina , P. Kotanidou Eleni , Bacopoulou Flora , Fidani Liana , Galli-Tsinopoulou Assimina , Christoforidis Athanasios

Objectives: Age at menarche depends on genetic, environmental, epigenetic and other factors. Studies have shown that aspects of perinatal history, including birth weight, mode of delivery (caesarian section or vaginal delivery) and gestational week at birth influence the onset of puberty. The purpose of this study was to record the age at menarche in a sample of Greek girls and to correlate it with their perinatal history, the mothers’ age at menarche, t...

hrp0098p1-85 | Pituitary, Neuroendocrinology and Puberty 1 | ESPE2024

Do aromatase inhibitors used during adolescence affect male reproductive function in adulthood? An exploratory study.

Dai Chengjun , Ding Jingchao , Zhang Junrong , Zhu Jianfang , Fang Yanlan , Wang Chunlin

Aim: Aromatase inhibitors are widely used in clinical practice and are currently employed in the treatment of adolescents with short stature. However, the impact of these inhibitors on the reproductive function in male adolescents remains unclear.Methods: The data of patient with short stature who had completed aromatase inhibition therapy between 2015 and 2022 at the First Affiliated Hospital of Zhejiang University Scho...

hrp0098p1-313 | Late Breaking 2 | ESPE2024

Do We Need Seasonal Thyroid Hormone Reference Values in Pediatric Endocrinology? Results from a Population-Based Study

Hirtz Raphael , Thamm Michael , Kuhnert Ronny , Thamm Roma

Studies in adults provide convincing evidence of seasonal fluctuations in thyroid hormone levels. However, the evidence in children and adolescents is less consistent, potentially due to unaddressed confounding and the use of statistical methods not well-suited to investigate this specific issue. Using the baseline data from KiGGS (German Health Interview and Examination Survey for Children and Adolescents), an analysis was conducted among 6,071 participants aged 6 to 17 years...

hrp0098p2-348 | Late Breaking | ESPE2024

Do aromatase inhibitors used during adolescence affect male reproductive function in adulthood? An exploratory study.

Dai Chengjun , Ding Jingchao , Zhang Junrong , Zhu Jianfang , Fang Yanlang , Wang Chunlin

Purpose: Aromatase inhibitors are widely used in clinical practice and are currently employed in the treatment of adolescents with short stature. However, the impact of these inhibitors on the reproductive function in male adolescents remains unclear.Methods: The data of patient with short stature who had completed aromatase inhibition therapy between 2015 and 2022 at the First Affiliated Hospital of Zhejiang University ...

hrp0095p1-285 | Fat, Metabolism and Obesity | ESPE2022

Nutritional disparities among Brazilian children: study of the temporal trend of the BMI from 2010 to 2021.

Machado Pinto Renata , Carvalho Lima Vitor , Marinho de Jesus Luciana , Barreira Duarte de Sousa Mariana , Paulo do Carmo Assunção Marcos , Lima Mutão Stival Nicolle , Oliveira Vaz Tiago

Introduction: The Body Mass Index (BMI) is an essential indicator for the nutritional assessment of children and reflects the exposure to health conditions that are harmful to the development of this population.Objective: To analyze the temporal trend of the BMI of Brazilian children, 0 to < 10 years old from 2010 to 2021.Methods: Descriptive ecological study. Data obtained from...