hrp0084p3-601 | Adrenals | ESPE2015

Central Cortisol Deficiency (Isolated ACTH Deficiency) in a Child

Alyafei Fawzia , Soliman Ashraf

Background: Isolated ACTH deficiency is a very rare condition, there is only seven cases in the literature reported after infancy and the cause is still unknown.Case study: We are reporting 11.5 years old Qatari boy who was known to have G6PD deficiency only and who presented with generalised tonic colonic seizure at the day of admission with history of fever, ear pain and discharge fatigue and excessive sleep, and vomiting for 4 days. He had fever (39C)...

hrp0084p3-974 | GH & IGF | ESPE2015

Linear Growth in a Child with Ellis Van Creveld Syndrome: Positive Effect of Growth Hormone Therapy

Soliman Ashraf , Alyafei Fawzia

Background: Ellis van Creveld syndrome (EVC) (chondroectodermal dysplasia) is a rare, multisystem disorder. It probably affects only around 1 in every 150,000 individuals. It is characterized by a long, narrow trunk and shortened arms and legs; extra fingers (postaxial polydactyly), and abnormalities of the oral region and teeth. In infants, non-bony manifestations, particularly congenital heart defects, may be health or life-threatening.Case presentatio...

hrp0084p3-1035 | Growth | ESPE2015

Two Cases with Decelerated Linear Growth, Normal GH – IGF1 Axis with an Exceptional Response to GH Therapy

Alyafei Fawzia , Soliman Ashraf

Introduction: Idiopathic short stature (ISS) describes short children with normal GH secretion. There is a lot of controversy about the outcome of treating ISS children with GH. Exceptional fast growth in response to GH therapy in these children enable scientist to delineate the different etiologies behind this broad term of ISSCase report: We are reporting two children aged 5 years and 9 years diagnosed with ISS. They presented with short stature with n...

hrp0095p1-304 | GH and IGFs | ESPE2022

Growth hormone deficiency and central hypothyroidism related to microarray abnormality involving a loss of ~111-kilobases (kb) within cytogenetic band Xq28 and a gain within cytogenetic band 20q11.22.

Soliman Ashraf , Alyafei Fawzia , Alaaraj Nada

Chromosomal microdeletions and microduplications have been associated with syndromic forms of intellectual disability (ID). The Xq28 duplication syndrome is an X-linked intellectual disability syndrome characterized by variable degrees of cognitive impairment (typically more severe in males), a wide spectrum of neurobehavioral abnormalities, and variable facial dysmorphic features. All males reported to date with the syndrome have a moderate-to-severe intellectual disability. ...

hrp0092p1-313 | Diabetes and Insulin (2) | ESPE2019

Familial Versus Non-Familial Type-2 Diabetes Mellitus in Children and Adolescents: Clinical and Biochemical Data.

Alyafei Fawzia , Soliman Ashraf , Sabt Aml , Aldarsy Nagwa

Familial clustering of type-2 diabetes is well-known. In adults, the prevalence of diabetes is higher among patients with diabetic parents. The Framingham offspring study found that maternal and paternal diabetes conferred equal risk for offspring type-2 diabetes.Objectives: We conducted this study to compare the clinical characteristics of children and adolescents with family history of type- 2 diabetes mellitus, in one or both parents,...

hrp0092p2-183 | Growth and Syndromes (to include Turner Syndrome) | ESPE2019

The Prevalence of Celiac Disease (CD) in Children with Type 1 Diabetes Mellitus (T1D); Does CD Adversely Affect Linear Growth in these Children?

Alyafei Fawzia , Soliman Ashraf , Sabt Aml , Elsayed Nagwa

The prevalence of biopsy-proven CD in T1D in pediatric populations widely ranges between 2.6 in Finland to 16.4 in Algeria. Many patients with CD and T1D are either asymptomatic (silent CD) or present with only mild symptoms. CD children may be less likely to show overt growth failure but can have weight and height measures at a lower growth percentile and complain of nonspecific symptoms, including anorexia and lassitude.Aim; Patients and Methods:<p...

hrp0089p2-p061 | Diabetes &amp; Insulin P2 | ESPE2018

The Prevalence of Double Diabetes in Children and Adolescents in Qatar

Soliman Ashraf , Alyafei Fawzia , Wasfy Reem , Aldarsy Nagwa

The incidence of both type 1 (T1DM) and type 2 diabetes (T2DM) has shown a rise in Qatar in parallel with a notable increase in the incidence of a new expression of the disease in children and adolescents, with the characteristics of a mixture of the two types of diabetes and referred to as Â’double diabetesÂ’ (DD). Insulin resistance and obesity, together with the presence of markers of pancreatic autoimmunity - namely, autoantibodies to islet cell antigens - typicall...

hrp0089p2-p087 | Diabetes &amp; Insulin P2 | ESPE2018

Translating the A1C Assay into Estimated Average Glucose Values in Children with Type 1 Diabetes Mellitus

Sayed Ahmed Mohamed , Alyafei Fawzia , Soliman Ashraf , Algamal Mona

Objective: The A1C assay, expressed as the percent of hemoglobin that is glycated, measures chronic glycemia and is widely used to judge the adequacy of diabetes treatment and adjust therapy. Day-to-day management is guided by self-monitoring of capillary glucose concentrations (milligrams per deciliter or millimoles per liter) as well as by using continuous glucose monitoring systems (CGMS). We found a mathematical relationship between A1C and average glucose (AG) levels meas...

hrp0082p3-d3-751 | Diabetes (4) | ESPE2014

Continuous Glucose Monitoring vs Oral Glucose Tolerance Test and HbA1C in the Evaluation of Glycemic Abnormalities in an Obese Adolescent Before vs After Partial Gastrectomy

Soliman Ashraf , Sabt Aml , Alyafei Fawzia , Eldarsy Nagwa

Background: We compared continuous glucose monitoring (CGMS) (Medtronic) to oral glucose tolerance test (OGTT) and HbA1c in the follow-up of glycemic abnormality in an adolescent girl with morbid obesity and glycemic abnormalities before and after 2 months of partial gastrectomy. This 16-year-old adolescent girl presented with obesity (weight 98 kg, height 158 cm, BMI=39.2 kg/m2), acanthosis nigricans and nocturnal polyuria and polydipsia. Trials to reduce weight th...

hrp0082p3-d2-855 | Growth (3) | ESPE2014

Effect of Cyanotic and Acyanotic Congenital Heart Disease on Placental and Birth Size

Soliman Ashraf , Shatlah Emad , Sabt Aml , Alyafei Fawzia , Alqadi Mohanad

Background: Abnormal cardiac development leading to CHD can be associated with abnormal placental development with abnormal trophoblast invasion and remodeling resulting in abnormal transfer of nutrients and oxygen.Objective and hypotheses: We measured the anthropometric parameters (length, weight, and head circumference) and the placental weight of 49 FT newborns (gestation period >36 weeks) infants with CHD ((cyanotic (n=8) and acyanotic (...