hrp0095p2-97 | Fat, Metabolism and Obesity | ESPE2022

Linear growth and prevalence of the different components of the metabolic syndrome (MetS) in young obese nondiabetic children (below 5 years) in comparison to older obese children (6-12 years)

Hamed Noor , Soliman Ashraf

Introduction: In Qatar, the prevalence of metabolic syndrome (MetS) in children and adults is increasing in parallel with the markedly increasing trends in obesity rates. We studied the prevalence of different components of MetS, measure plasma atherogenic indexes (AIP), and linear growth in young obese nondiabetic children (< 5 years) in comparison to older obese children (6-12 years).Methods: We analyzed the anthrop...

hrp0092p3-50 | Diabetes and Insulin | ESPE2019

Hybrid Diabetes with Good Response to Metformin in an Adolescent with Polyglandular Polyendocrinopathy (APS2)

Hamed Noor , Soliman Ashraf

Introduction: Development of type 1 diabetes is well known in cases of type 2 autoimmune polyglandular syndrome (APS). We describe a case of APS2 who developed a hybrid form of diabetes that responded to metformin therapy.Case: The patient is a 17.5 year old male patient who has been diagnosed with APS2 at the age of 13 years with primary adrenal insufficiency and autoimmune hypothyroidism .he has been on treatment with ...

hrp0095p2-167 | Growth and Syndromes | ESPE2022

Short stature and mild developmental delay in a child with partial duplication of DIAPH2 gene: good response to recombinant Growth Hormone therapy: A Case Report

Elsiddig Sohair , Hamed Noor , Soliman Ashraf

Introduction: The DIAPH2 gene (Diaphanous homolog 2 Drosophila) is a Protein Coding gene found on the long arm of the X chromosome and is a member of the FH1/FH2 protein family. Members of this family affect cytokinesis and other actin-mediated morphogenetic processes required in early gonadal development.Case Description: An eight-year-old girl was referred with a chief complaint of short stature. She is a product of no...

hrp0092p3-74 | Diabetes and Insulin | ESPE2019

Does Metformin Therapy Prolong the Honeymoon Period in Obese Adolescent with Hybrid Diabetes?

Hamed Noor , Elawwa Ahmed , Soliman Ashraf

Introduction: Hybrid diabetes is a challenging form od diabetes that need to be more studied. We describe a case of hybrid diabetes with a prolonged honeymoon due to the use of metformin.Case: Our patient is a 10 year old female patient who was diagnosed as type 2 DM on September 2017 at the age of 8 years. She was obese with BMI = 29.8 Kg/ m^2 with marked acanthosis nigricans. She had a patch of vitiligo on the face...

hrp0094p2-306 | Growth and syndromes (to include Turner syndrome) | ESPE2021

Growth hormone deficiency (GHD) with high circulating insulin-like growth factor-1 (IGF-1) in an adolescent with celiac disease: Is it IGF-1 insensitivity?

Alaaraj Nada , Soliman Ashraf , Hamed Noor ,

Impaired growth in children with Celiac Disease (CD) results mainly from nutritional deficits. Withdrawal of gluten from the diet is frequently associated with a marked improvement of linear growth. Some CD patients still have impaired growth despite good gluten elimination. GH secretion should be evaluated in CD patients showing no catch-up growth. We describe a case with CD and severe linear growth retardation due to possible IGF-1 resistance.Case Pres...

hrp0095p1-138 | Multisystem Endocrine Disorders | ESPE2022

Long-term Growth and Endocrine Complications of Bone Marrow Transplantation in Children and Adolescents with Beta-Thalassemia Major: Comparison with Conventional treatment

Ahmed Shayma , Soliman Ashraf , Alaaraj Nada , Hamed Noor

Introduction: The conventional approach to the treatment of Beta- thalassemia major (BTM) is based on the correction of hemoglobin status through regular blood transfusions and iron chelation therapy for iron overload. Allogeneic hematopoietic stem cell transplantation (HCT) remains the only currently available technique that has curative potential. No previous study compared the long-term growth and endocrinopathy changes among large cohorts of BTM patients o...

hrp0095p2-100 | Fat, Metabolism and Obesity | ESPE2022

Comparison between Triglyceride-Glucose Index (TyG) and Atherogenic index of plasma (AIP) in relation to the different components of the metabolic syndrome (MetS) in morbidly obese children

Hamed Noor , Soliman Ashraf , Alaaraj Nada , Ahmed Shayma

Background: Metabolic syndrome (MetS) is related to increased cardiovascular complications of obesity. The triglyceride-glucose (TyG) index is frequently used as an indicator of insulin resistance in adults. However, there is scant information on the TyG index in the morbidly obese Pediatric population, nor is its correlation with the components of the metabolic syndrome (MetS).Methods: We compared the use of TyG vs athe...

hrp0092p2-43 | Bone, Growth Plate and Mineral Metabolism | ESPE2019

A Rare Form of Vitamin D Receptors Dysfunction (vitamin D-dependent Rickets Type II) with Alopecia. A Case Report

Ahmed Shayma , Soliman Ashraf , Elawwa Ahmed , Hamed Noor , Alaaraj Nada

Introduction: VDDR II is an autosomal recessive disorder caused by a defect in the vitamin D receptor gene located on chromosome 12q12–q14. Thus far, 13 mutations have been identified. It is characterized by hypocalcemia, secondary hyperparathyroidism, and early onset severe rickets. Here we report a case of a severe form of rickets associated with alopecia.The Case: This 23-month-old boy was born at term to consang...

hrp0089p3-p114 | Diabetes &amp; Insulin P3 | ESPE2018

Metformin Therapy Ina Lean Adolescent Girl with Prediabetes Dysglycemia Treated: Good Response

AlAaraj Nada , Hermi Amene , Hamed Noor , Ahmed Shaymaa , Soliman Ashraf

Background: Metformin (dimethylbiguanide) is the most widely prescribed treatment for children with T2DM. Long term controlled studies are still required to assess its effect on prediabetes dysglycemia in childrenCase presentation: A 13-year-old lean adolescent girl presented to PEC with a day history of difficult breathing associated with dry cough. No history of fever, abdominal pain, vomiting or change in bowel motion. She had a 10 months’ histor...

hrp0094p2-415 | Sex differentiation, gonads and gynaecology or sex endocrinology | ESPE2021

Obesity, ovarian mass, vaginal bleeding and hypothyroidism in a 5-year-old female girl

Alhemaidy Noora , Alaaraj Nada , Soliman Ashraf , Hamed Noor , Ahmed Shayma

Introduction: Van Wyk-Grumbach Syndrome (VWGS) is a constellation of symptoms including precocious puberty without adrenarche, delayed bone age, ovarian cysts, and hypothyroidism.Case report: We report here a five-year-old girl who presented for evaluation of obesity, abdominal distension, vaginal bleeding, and abdominal distention. Her HtSDS =-1.3 and BMI SDS =1.5. A large abdominal mass was palpable. She had no breast development or pubic hair. Her Inv...