ESPE Abstracts

Objective: The mechanism underlying postnatal growth failure and catch up growth in small for gestational age (SGA) is poorly understood. This study attempted to identify exosomal miRNA signature associated with catch – up growth in SGA children.Methods: A total sixteen SGA children and 10 appropriate for gestational age (AGA) children included in this study. Exosomal miRNA was analyzed with next generation sequenc...

Introduction: C-type natriuretic peptide (CNP, NPPC gene) and its receptor, natriuretic peptide receptor B (NPR-B, NPR2 gene), is critical for endochondral ossification in growth plate. Biallelic NPR2 mutations are known as acromesomelic dysplasia, type Maroteaux which is characterized by severe short stature. A monoallelic NPR2 mutation has been suggested to mildly impair long bone growth.Obje...

Background/aim: Anti – Müllerian hormone (AMH) and Inhibin B (INHB) are considered as possible biomarker of central precocious puberty(CPP). This study investigated serum AMH and INHB level in central precocious puberty andanalyzed clinical factors associated with these two hormone levels.Methods: In total, 48 girls with CPP and 35 age – matched prepubertal girls were enrolled in the study. The subjects were divided into two groups as CPP ...

Background: Although the beneficial effects of GH treatment on statural growth are well known, the impacts on skeletal maturation are not fully understood. In the current study, we aimed to investigate the progression of bone age (BA) in children with idiopathic GH deficiency (iGHD) and idiopathic short stature (ISS) based on a LG Growth Study (LGS). We also evaluated the progression rate of BA relative to chronologic age (CA) between iGHD and ISS and to find their associated ...

Background: In girls with central precious puberty (CPP), the hypothalamic-pituitary-gonadal axis is prematurely activated. If the girl is treated with GnRH agonist (GnRH-a), gonadotropins levels become suppressed.Objective and hypotheses: We aimed to evaluate whether serum antimu llerian hormone (AMH) and inhibin B levels are affected in girls with CPP and whether pituitary suppression by GnRH-a affects serum AMH and inhibin B levels.<p class="abste...

Background: Precocious puberty (PP) is associated with psychological and behavioral problems. However, little is known about body image and psychological features in girls with PP, being treatment with GnRH analogues.Objective and hypotheses: This study aimed to evaluate the perception of body image and self-esteem in girls with PP, were receiving GnRH analogue therapy.Method: From March to August 2013, 82 girls with PP with GnRH a...

Background: As metabolic complication and polycystic ovarian syndrome due to childhood obesity is rising, the role of hyperandrogenemia (HA) and hyperinsulinism is receiving attention.Objective and hypotheses: The aim of this study was to investigate the presence or absence of obvious HA according to pubertal status and to find potential etiologic determinants of HA in Korean obese girls.Method: We analysed 91 subjects aged 6–...

Background: Triglyceride and glucose (TyG) index is significantly associated with higher risk of developing type 2 diabetes mellitus (T2DM). The mechanism of the role of TyG index in the development of T2DM is not clear. There are few studies on the relationship between the TyG index and homeostatic model assessment of insulin resistance (HOMA-IR).Aims: To elucidate the role of the TyG index, studies are needed on the association between...

Background: Perturbation of inflammation is critically linked to nutrient metabolic pathways and obesity-associated complications, such as insulin resistance and type 2 diabetes (T2DM). The S100 family of proteins, including S100A8/A9 (calprotectin), have been implicated in disease pathogenesis and investigated as potential markers of inflammation. In adults, increased circulating levels of calprotectin have been reported in obesity-related chronic low-grade i...

Purpose: Vitamin D deficiency (VDD) is very common nowadays in children as well as in adults, probably due to decreased exposure to sunlight. In Korea, the prevalence of VDD was 47% in teenage boys and 65% in teenage girls. However, the optimal dosage regimen for correcting deficiency is unknown. We investigate the change of serum 25(OH) vitamin D concentration according to the treatment dosage and duration in VDD.Methods...