hrp0098p2-338 | Late Breaking | ESPE2024

Reducing BMI below the obesity threshold in children aged 6 to <12 years treated with once-daily liraglutide 3.0 mg: A secondary analysis of the SCALE Kids study

K. Fox Claudia , Barrientos-Pérez Margarita , M. Bomberg Eric , Dcruz John , Gies Inge , Majlund Harder-Lauridsen Nina , Yazid Jalaludin Muhammad , Sahu Kushal , Weimers Petra , Zueger Thomas , Arslanian Silva

Childhood obesity is associated with present and future complications, including type 2 diabetes and cardiovascular disease. Although lifestyle interventions (i.e. dietary and physical activity counselling) are the cornerstone of therapy, their impact on body mass index (BMI) is limited. The phase 3a SCALE Kids study (NCT04775082) demonstrated superiority of liraglutide 3.0 mg versus placebo, plus lifestyle interventions, for BMI reduction in children with general (i.e. non-mo...

hrp0092hdi2.1 | How Do I Session 2 | ESPE2019

How do I…. Manage Micropenis in a Child

Bertelloni Silvano , Tyutyusheva Nina

Micropenis is defined as a penile length less than 2.5 SD below the mean value for a given age (eg, <2.5 cm at term). Nowadays, it should be also diagnosed in utero by sonography. The incidence of micropenis has been reported as 1.5/10.000 male infants in Usa, 5/1.442 in France and 18/2710 in Brazil, suggesting geographical differences or different assessment. Micropenis represents a clinical sign, that may be part of various clinical conditions, such as hypogonad...

hrp0092p1-133 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2019

Congenital Disorders of Reproductive Hormones in Mini-puberty Boys with Bilateral Cryptorchidism

Raygorodskaya Nadezda , Bolotova Nina

Background: cryptorchidism is associated with the high risk of infertility. In some cases it may be the one of the first symptom of congenital hypogonadism. The period of 0 – 6 month of life is a short window for postnatal testicular maturation and the diagnostic of reproductive disorders.Objective: to evaluate the functional condition of pituitary and gonads in mini-puberty boys with bilateral cryptorchidism.<p...

hrp0084p2-506 | Perinatal | ESPE2015

Mini-Puberty in Boys with Cryptorchidism

Raygorodskaya Nadezda , Bolotova Nina

Background: The period of transitory postnatal activation of the hypothalamo-pitutary-gonadal axis (mini-puberty) plays an important role in the testicular maturation.Objective and hypotheses: To evaluate the functional condition of the gonads in 1–3 months boys with cryptorchidism.Method: 40 boys ages 1–3 months with cryptorchidism were examined: group 1–30 boys with unilateral inguinal retention testis and group 2&...

hrp0095p2-81 | Diabetes and Insulin | ESPE2022

Steroid-induced diabetes mellitus in children and adolescents: risk factors, course features, treatment specifics and prognosis on example of 10 patients

Frolova Elena , Shirokova Irina , Makretskaya Nina

Background: SIDM is not a common complication of high-dose glucocorticoid therapy (HD-GC) in pediatric practice. There are no clear generally accepted approaches to SIDM treatment. In 10 cases, we present the identified patterns of predictors, course, features of the treatment of SIDM in children and adolescents.Methods: 10 case histories of children with SIDM were analyzed. 4 boys, 6 girls, age 8-17.5 years, median 15 y...

hrp0089p2-p019 | Adrenals and HPA Axis P2 | ESPE2018

Two Cases of Apparent Mineralocorticoid Excess due to Novel Mutations in HSD11B2 Gene

Makretskaya Nina , Kostrova Irina , Tiulpakov Anatoly

Background: Human HSD11B2 metabolizes active cortisol into cortisone and protects the mineralocorticoid receptor from glucocorticoid occupancy. Loss of function mutations in HSD11B2 gene cause a rare autosomal recessive disorder, apparent mineralocorticoid excess, resulting in low-renin hypertension and hypokalemia.Objective: We present 2 children with apparent mineralocorticoid excess. Case 1, a boy presenting at 11 yea...

hrp0089p3-p274 | Multisystem Endocrine Disorders P3 | ESPE2018

The Case of Combination of Multinodular Goiter and Sertoli-Leydig Cell Ovarian Tumor due to Mutation in DICER1 Gene

Kolodkina Anna , Makretskaya Nina , Tiulpakov Anatoly

Background: Pathogenic germline DICER1 variants cause a hereditary cancer predisposition syndrome with a variety of manifestation. In addition to conferring increased cancer risks for pleuropulmonary blastoma (PPB) and ovarian sex cord-stromal tumors, particularly Sertoli–Leydig cell tumor, individuals with pathogenic germline DICER1 variants could also have lung cysts, cystic nephroma, multinodular goiter, ciliary body medulloepithelioma, genitourinary embryonal rhabdomy...

hrp0084s3.2 | Disorders of sex development: An update | ESPE2015

Decision Making in DSD: Development of a Decision Support Tool

Sandberg David , Callens Nina , Siminoff Laura

Background: Disorders/differences of sex development (DSD) differ from other rare conditions which are often accompanied by significant morbidity and mortality. With limited exceptions, DSD are not life-threatening and do not predict a given level of physical health or health-related quality of life across the lifespan. The birth of a child with DSD is anxiety-provoking. Stressors include weathering drawn-out diagnostic testing, difficulty absorbing complex medical information...

hrp0094p2-155 | Diabetes and insulin | ESPE2021

Dyslipidaemia in children with type 1 diabetes mellitus

Nikolaeva Nadezhda , Gumeniuk Olga , Bolotova Nina ,

Dyslipidemia is one of the major risk factors for cardiovascular disease in diabetes mellitus. The characteristic features of diabetic dyslipidemia in adults are a high plasma triglyceride concentration, low HDL cholesterol concentration and increased LDL cholesterol. Dyslipidaemia in children with type 1 diabetes mellitus (T1D) have been little studied (P. Lozano et al., 2016; J. D. Schofield et al.,2016; M. Kinoshita et al., 2018; C.Elkins et al., 2019). DECODE studies (Diab...

hrp0097p1-442 | Diabetes and Insulin | ESPE2023

Identification of GCK-MODY in case of neonatal hyperglycemia

Hakobyan Nina , Avetisyan Susanna , Markosyan Renata

Neonatal Diabetes mellitus (NDM) is a rare genetic disease. In this report, we presented a case of NDM due to mutation in GCK gene. A male baby born to a non-consanguineous parent at 42 weeks of gestation with a birth weight of 3.2 kg. The mother was diagnosed with gestational diabetes; no special treatment was given. The first episode of hyperglycemia was registered at the age of 13 days at hospitalization due to bronchitis /blood glucose -6.2⁓7.9 mmol/l. Due to mild h...