ESPE Abstracts

In recent years, the problem of androgen deficiency as a factor in the formation of dyslipidemia, endothelial dysfunction, insulin resistance and systemic inflammation has been studied mainly in adult men, because the main cause of mortality and disability in this cohort is cardiovascular disease. However, there are practically no data on the relationships of sex hormones with lipid metabolism during hypoandrogenism (HA) during puberty.Aim of research: w...

The changes of the immune reactivity, the production of hormones and the neuroendocrinal regulation of immune homeostasis are the entities closely connected with the puberty. There is evidence for the role of cytokines in securing of intersystemic interaction as well as for the influence of reproductive hormones on the cytokine production. However, the question as to the role of cytokine in the formation of delayed puberty continues to be relevant.<stron...

Background: The negative effect of military conflicts on the health of the child population is a proven fact. The consequences of modern military conflicts for the physical development of children are practically not studied.The aim: Of the study is to assess the nature of the physical development of children affected by the military conflict in the East of Ukraine.Materials and methods: At the 179 girls and 128 boys aged 6–18...

Background: The most common cause of permanent neonatal diabetes (PNDM) is heterozygous activating mutations in the KCNJ11 gene encoding the pore-forming Kir6.2 subunit of the pancreatic beta cell KATP channel.Objective and Hypotheses: To determine the dynamic of carbohydrate metabolism in family transferred from insulin to sulphonylureas (SU).Method: We studied a family (...

Background: Insulin therapy by creating a subcutaneous depot remains an integral part of the treatment of diabetes in children. Places of insulin administration are restricted to certain parts of the body and the condition of subcutaneous fat affects the variability of glycaemia no less than quality of insulin. Formation of lipodystrophies (LD) causes glycaemia variability, difficulties in selection of insulin doses and achieving disease compensation.Obj...

Background: To achieve the compensation of type 1 diabetes, psychological factors that contain individual psychological characteristics of the patient’s personality, his emotional state and responsibility for his own health are important.Objective and hypotheses: The purpose of the study was to study the specifics of responsibility for the health of adolescents with type I diabetes of different sex, depending on the level of glycemic control (GC).</...

Background: Dystopia thyroid is an anomaly of development and is the result of a violation of embryogenesis and often remains unrecognized, the true frequency of the dystopia of the thyroid gland is not known, described 800 cases of ectopic thyroid gland in the region of blind holes of the tongue in adults and 80 cases in children, half of them diagnosed congenital hypothyroidism.Objective and hypotheses: To reveal some features in the diagnosis and trea...

Background: Neonatal diabetes is a rare pathology occurring in around one in every 200 000–400 000 live births. The most common cause of permanent neonatal diabetes (PNDM) is heterozygous activating mutations in the KCNJ11 gene encoding the pore-forming Kir6.2 subunit of the pancreatic β cell KATP channel.Objective and hypotheses: To determine the dynamic of carbohydrate metabolism in family transferred from insulin to sulphonylureas (...

Background: Vascular Endothelial Growth Factor (VEGF) is largely produced by adipose tissue and is an important regulator of physiological and pathological angiogenesis in adults with obesity.Objective and hypotheses: To determine the nature of VEGF production and its connection to the formation of vascular complications in patients with childhood obesity.Method: In 87 children (42 boys and 45 girls) 9–17 years old with obesit...

Background: Psychological characteristics of patients with type 1 diabetes mellitus (DM1) factor significantly into the effectiveness of disease self-control training. An important part of I-concept of child with DM1, along with internal picture of disease, is internal picture of health (IPH). IPH is an individual’s special attitude towards his/her health, represented by recognizing its value and taking active and positive effort to improve it.<p clas...