ESPE Abstracts

Background: Premature adrenarche (PA) is characterized by an advanced bone age (BA) relative to chronological age (CA); nevertheless, clinical importance of this is not entirely understood. Literature contains few data on the impact of increased BA on adult height (AH) in PA. Objective of this study is to assess AH in girls with PA, and factors influencing AH.Methods: Retrospective analysis was carried out on 477 girls w...

Introduction: Resistance to thyroid hormones is defined as lack of response of peripheral tissues to triiodothyronine (T3) which is the active form of thyroid hormones. In general (85%) a mutation is detected in the thyroid hormone receptor β (THRB) gene and more rarely, the thyroid hormone receptor α (TRHA) gene.Case: A 4.7-year-old boy, was admitted to the pediatric endocrinology outpatient clinic of Akdeniz...

A rare case of a 4-year-old boy with a SRY-positive 45, X karyotype was presented. Family history of the child was not remarkable. His height and weight were -2.1 SD and -1.4 SD, respectively. Physical examination revealed a well-developed penis with hypospadias. His right testis was in the scrotum and the left testis was not palpable. In previous inguinal exploration recordings, unilateral testicular agenesis on the left side were noted. The right testis was biopsied and prep...

Background: Insulin resistance is predominantly associated with obesity. The euglycemic hyperinsulinemic clamp test, the gold standard for diagnosis of insulin resistance, has limited practical application. Although oral glucose tolerance test (OGTT) is generally used instead, there remains a need for more practical methods in outpatient clinics.Aim: The objective of this study is to assess the outcomes of the OGTT in no...

Aim: This study aims to evaluate the comparative effects of the Minimed 780G system initiated at the time of diagnosis and subcutaneous insulin therapy with continuous glucose monitoring (CGM) systems also initiated at the time of diagnosis on metabolic control and CGM metrics.Methods: We enrolled 8 participants who started using the Minimed780G and 7 participants who started using continuous glucose monitoring (CGM) + m...

Purpose: This study aimed to determine the prevalence and predictors of Euthyroid Sick syndrome (ESS) in pediatric intensive care, and to establish a link between thyroid function tests and mortality.Methods: Between January 2015 and March 2020, children admitted to our pediatric intensive care unit (PICU) and tested for free triiodothyronine (fT3), free thyroxine (fT4), and thyrotropin (TSH) levels were included. Patien...

Introduction: The prevalence of celiac disease is 5–10 times higher in patients with type 1 diabetes mellitus (DM) than in the general population. Therefore, celiac serology should be screened intermittently in type 1 DM patients. However, anti-tissue transglutaminase (anti-TTG) antibody elevation may be detected incidentally at the time of type 1 DM diagnosis and regress spontaneously during follow-up, without medical or dietary interventions.<p clas...

Introduction: Autoimmune polyendocrinopathy type 1 (APECED) is an autosomal recessive disease caused by loss of function mutations of autoimmune regulatory (AIRE) gene. Characteristically, early onset ectodermal dysplasia, mucocutaneus candidiasis is followed by hypoparathyroidism and primary adrenal insufficiency usually within the first two decades. Although clinical features may be variable, recently, it is suggested that population characteristics and natu...

Introduction: Parathormone-related peptide (PTHrP) regulates tissue calcium concentration by acting in paracrine or autocrine ways. It is mostly responsible for paraneoplastic hypercalcemia seen in adults. Paraneoplastic hypercalcemia in children is rarely reported in cancers such as ALL, medulloblastoma and hepatoblastoma (0.4–0.7%). In experimental studies, PTHrP is shown to be synthesized apart from neoplastic tissue (glomerulus and tubule cells).<p class="abstext"...

Objective: Initiation of continuous subcutaneous insulin therapy (CSII) requires an appropriate basal rate profile. Although different approaches exist; there is a lack of evidence-based recommendations, especially in young children. Our aim was to show how the % of basal rates change at the end of first year of therapy when basal rates are equally distributed at the start of therapy.Materials and Methods: In this survey, 129 CSII patients were analyzed....