ESPE Abstracts

Objectives: We designed a longitudinal study to investigate the association between central pubertal activation with age at the appearance of clinical signs of puberty. We, therefore, assessed nocturnal gonadotropin secretion which can be detected in the form of total luteinizing hormone (LH) immunoreactivity in the daytime- and sleeptime-excreted urine.Methods: Thirty healthy volunteers (17 boys and 13 girls, aged 3.4&n...

Key words: Childhood, Obesity, Periaortic fat thickness, Echocardiography, Cardiovascular risk.Aim: To assess the periaortic fat thickness (PAFT) by echocardiograpy in a cohort of children with simple obesity and to evaluate its relationship to clinical and metabolic cardiovascular risk factors.Methods: Fifty children and adolescents with simple obesity and 25 healthy sex and age m...

Background: Hypoglycaemia is one of the most common presenting complaints at paediatric emergency department. There are many distinct causes of hypoglycaemia, ranging from nutritional insufficiency, infectious origins, to metabolic disorders. A thorough investigation can help differentiate the cause of hypoglycaemia, with subsequent tailored management. All patients with hypoglycaemia should have a full clinical assessment and together with a hypoglycaemia scr...

Introduction: The steroid metabolism of the newborn and infant is subject to rapid changes and is extremely difficult and complex to assess. Of all analytical techniques, the platform technology of GC-MS allows the most comprehensive assessment of the entire steroid metabolome and this approach is also non-invasive.Method: In order to characterize the essential changes in steroid metabolism during infancy, a total of 355...

Background: Acquired hypothalamic dysfunction (HD) in children following suprasellar brain tumor treatment may be caused by the tumor or its treatment (neurosurgery, radiotherapy). Rapid weight gain, obesity and pituitary dysfunction are readily recognized as symptoms of HD, however HD knows other signs and symptoms such as hypothermia, adipsia and behavioral problems. In our clinical experience, signs and symptoms of HD may differ per tumor type and the treat...

Introduction: The EQ5D questionnaire is an openly available, validated, age-specific and generic measure of quality of life (QoL) which takes less than 5 minutes to complete. A higher dimension score and a lower visual analogue scale (VAS) is associated with worse QoL. Our aim was to use this tool to assess the QoL of patients with a wide range of paediatric endocrine conditions in the routine clinical setting.Methods: B...

Introduction: Type I diabetes (T1D) is an autoimmune disease that might be associated with a family history of T1D (1). In Kuwait, pediatric diabetes is a growing healthcare concern with limited knowledge about familial T1D. We aim ed to identify the prevalence, clinical, and biochemical characteristics of familial T1D in Kuwait.Methods: All children (aged ≤12 years old) diagnosed with T1D between 2011-2022 and were r...

Objectives: We aim ed to validate first-morning-voided (FMV) total urinary luteinizing hormone immunoreactivity (U-LH-ir) as a marker for the onset of biochemical puberty and as a noninvasive method to predict the imminent onset of clinical puberty.Methods: We analyzed 651 children (305 boys aged 2.8–17.8 years and 346 girls aged 2.6–18.0 years, both spanning Tanner stages 1-5) across two distinct cohorts. In...

Background: Pituitary hyperplasia secondary to primary hypothyroidism has been reported in adult patients but is rare in paediatric patients. Despite advances in imaging technology, distinguishing between pituitary adenoma and pituitary hyperplasia remains a challenge. This differentiation is important as the primary modality of treatment in hyperplasia is thyroid hormone replacement and not neurosurgical intervention.Case report...

Background: Caregivers of patients with Bardet Biedl syndrome (BBS) face substantial burden from highly prevalent features of the disease, namely hyperphagia, or uncontrollable hunger, and obesity. However, the burden experienced by caregivers of individuals with BBS is not well characterized.Methods: A multicountry cross-sectional survey of caregivers of individuals with BBS was conducted to quantify the burden experien...