ESPE Abstracts

Childhood obesity (CO) is an important risk factor for the development of many chronic metabolic diseases in adulthood. Sleep patterns are known to affect leptin and ghrelin levels in the body. Recent studies using Functional Magnetic Resonance Imaging (fMRI) have shown that insufficient sleep time leads to unhealthy eating behaviors in the brain. The aim of this study is to investigate the association between sleep time in childhood and obesity. Consistent with this associati...

Studies show that vitamin D deficiency can have negative effects on glucose homeostasis, although the mechanism for this is still unclear. The possible mechanism may be related to the presence of vitamin D receptors and their metabolizing enzymes in insulin-sensitive cell types, such as pancreatic cells and adipocytes. The aim of this study is to compare how serum 25- OH D level and HOMA-IR index are related to acanthosis nigricans (AN) and which of them is a better marker for...

In children and adolescents, vitamin D deficiency negatively affects muscle physiology, exposing them to increased muscle damage and pain, stress fractures, and tendon structures. In addition, free radicals released when the body is exposed to oxidative stress after exercise can cause DNA damage. Vitamin D plays an important role in removing these radicals. The purpose of this study is to investigate the relationship between physical activity and 25- OH vitamin D in obese chil...

Childhood obesity (CO) is an important risk factor for the development of many chronic metabolic diseases in adulthood. Understanding the mechanisms that promote childhood obesity and eliminating these causes in childhood are critical for later life. One of the major complications of obesity is insulin resistance. The purpose of this study is to investigate the relationship between sunlight exposure and insulin resistance in childhood. Specifically, it examines how the duratio...

Objective: Obesity is a multifactorial genetic disorder. Monogenic obesity, explaining 5-13% of early-onset cases, is often associated with hyperphagia and reduced energy expenditure. Syndromic obesity involves additional clinical features such as developmental delay, hypogonadism, and sensorial hearing deficits. This study aims to enhance the understanding and management of patients with syndromic obesity by evaluating their anthropometric, laboratory, and cl...

Carney Complex (CNC) is a rare genetic disorder characterized by multiple endocrine and nonendocrine neoplastic manifestations across various organ systems, primarily driven by mutations in the PRKAR1A gene. The most common clinical effects are on the adrenocortical axis. This study seeks to dissect the clinical heterogeneity observed in CNC patients with PRKAR1A mutations, emphasizing the adrenocortical axis and its impacts on patient outcomes.C...

Objectives: American Thyroid Association (ATA) and European Thyroid Association (ETA) published guidelines about evaluation, treatment and follow-up. Despite these recommendations, published data on this subject is insufficient. This study aims to investigate the outcome of pediatric DTC and factors predicting the response to therapy in pediatric DTC.Methods: Medical records of 46 children diagnosed with DTC, between 200...

Objective: The use of glucagon-like peptide-1 (GLP-1) agonists for the medical treatment of childhood obesity was approved by the FDA four years ago; however, clinical experiences are limited. In this context, our study aims to present the clinical data of obese adolescents receiving liraglutide treatment in our clinic, providing preliminary insights into its efficacy and potential benefits.Method: We retrospectively eva...

Objectives: The incidence and importance of endocrine comorbidities related to cystic fibrosis-related diabetes (CFRD) and bone diseases (CFRBD) increase with age. Recent studies have indicated that insulin deficiency in type 1 diabetes mellitus(T1D) may be associated with an increased risk of osteoporosis. Our study aims to evaluate the relationship between glucose metabolism and bone health in pediatric cystic fibrosis patients.<strong...