hrp0089p3-p346 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P3 | ESPE2018

Ovotesticular Disorder of Sexual Development: 31 Cases Followed-up in a Single-Center in Brazil

Melardi Julia , Cunha Diego , Ferreira Marianna , Brigatti Nathalia , Carvalho Filomena , Cominato Louise , Steinmetz Leandra , Damiani Durval

The Ovotesticular Disorder of Sexual Development (OT DSD) is a rare condition characterized by histologic demonstration of both ovarian and testicular tissue in the same individual. Descriptions in literature usually have small samples and do not include patient evolution data. The aim of this study is to describe clinical, biochemical and histological findings, as well as long-term outcomes (including onset and progression of puberty) in patients with OT DSD, accompanied betw...

hrp0086p2-p500 | Fat Metabolism and Obesity P2 | ESPE2016

Prevalence and Characteristics of Polycystic Ovary Syndrome in Obese Adolescents

Ybarra Marina , Franco Ruth , Cominato Louise , Sampaio Raissa , Sucena Silvia , Damiani Durval

Background: Polycystic ovary syndrome (PCOS) in adolescence has a challenging diagnosis and therefore has raised intense discussions. Its prevalence in childbearing age women ranges from 5 to 10%. However, the prevalence in obese adolescents has not yet been reported. Besides, the relationship of PCOS with metabolic and cardiovascular disorders in this specific population has not been established.Objective and hypotheses: We aimed to assess the prevalenc...

hrp0084p2-337 | Fat | ESPE2015

Laparoscopic Sleeve Gastrectomy in Adolescents: Metabolic Consequences

Ybarra Marina , Franco Ruth , Cominato Louise , Velhote Manoel Carlos , Damiani Durval

Background: Severe obesity (SO), defined as BMI ≥95th percentile, has increased worldwide among adolescents. American studies estimated that 1.3–2.8% of 12–19-year-old individuals have a BMI >40 kg/m2 or a BMI >35 kg/m2 with at least one serious co-morbidity. The immediate and long-term risks associated with SO in adolescents include cardiovascular and metabolic diseases, obstructive sleep apnoea, and nonalcoholic fatty liver disea...

hrp0086p2-p542 | Fat Metabolism and Obesity P2 | ESPE2016

Obstructive Sleep Apnea Syndrome in Early Childhood: Case Report

Rachid Ludmilla , Queiroz Edjane , Cominato Louise , Rocha Ruth , Ybarra Marina , Steinmetz Leandra , Semer Beatriz , Menezes Filho Hamilton , Damiani Durval

Background: Obstructive sleep apnea syndrome (OSAS) in children is a common medical disorder, often associated with adenoid and tonsil hypertrophy. The prevalence of OSAS has been increasing due to alarming rates of obesity in childhood. This is a very concerning subject since there is a higher risk of cardiovascular outcomes in patients with elevated BMI and OSAS.Objective and hypotheses: The aim of this study is to report a hazardous case regarding chi...

hrp0084p3-877 | Fat | ESPE2015

Higher Hb1Ac in Obese Prader-Willi Syndrome Patients vs Obese Controls

Passone Caroline , dos Santos Tiago Jeronimo , Ito Simone Sakura , Ybarra Marina , Cominato Louise , Franco Ruth , Damiani Durval

Background: Obesity in Prader-Willi Syndrome has peculiar features associated to reduced lean body mass which could confer different metabolic characteristics.Objective and hypotheses: The aim of this study is to describe and to compare the metabolic profile in obese patients and obese Prader-Willi syndrome patients (OPWS) followed in a Pediatric Endocrinology outpatient clinic.Method: 45 obese and 22 OPWS patients between 8 and 20...

hrp0092p1-39 | Fat, Metabolism and Obesity | ESPE2019

Differences Between Short- and Long-term Outcomes of Laparoscopic Sleeve Gastrectomy in Adolescence

Ybarra Marina , Rocha Franco Ruth , Santos Tiago Jerônimo dos , Rachid Ludmilla , Bezerra Marilia P. C. , Cominato Louise , Damiani Durval , Prieto Velhote Manoel Carlos

Background: Laparoscopic sleeve gastrectomy (LSG) has been established as a safe and effective bariatric procedure during adolescence, but its long-term results remain uncertain. Our aim was to report and compare the short- and long-term outcomes of LSG in adolescents.Methods: We performed a retrospective analysis of patients submitted to LSG between 2010 and 2013 in our Institution. Baseline, short-term (1 year) and lon...

hrp0089p3-p147 | Fat, Metabolism and Obesity P3 | ESPE2018

Bariatric Surgery as Treatment of Primary Pseudotumor cerebriin a Male Adolescent: Case Report

Ybarra Marina , Jeronimo dos Santos Tiago , Santos Queiroz Edjane , Rachid Ludmilla , Rocha Franco Ruth , Cominato Louise , Castelo Moura Frederico , Carlos Velhote Manoel , Damiani Durval

Introduction: Primary Pseudotumor cerebri (PPTC), also known as idiopathic intracranial hypertension, is clinically characterized by increased intracranial pressure in an alert and oriented patient, with no evidence of deformity or obstruction of the ventricular system on neuroimaging. Cerebrospinal fluid analysis is normal except for increased intracranial pressure at lumbar puncture, greater than the 90th percentile (28 cm of H2O) in the pediatric population. Papilledema may...

hrp0086p2-p69 | Adrenal P2 | ESPE2016

Exaggerated Adrenarche and Exogenous Obesity: A Diagnostic Challenge

Ferreira Marianna , Semmer Beatriz , Queiroz Edjane , Brigatti Nathalia , Pinheiro Claudia , Athayde Debora , Steinmetz Leandra , Cominato Louise , Menezes Filho Hamilton , Kupperman Hilton , Setian Nuvarte , Damiani Durval

Background: The exaggerated adrenarche is an extreme variant of the maturation of the adrenal cortex, often associated with hyperinsulinemia and obesity. Hyperandrogenism by congenital adrenal hyperplasia (CAH) and adrenal neoplasms are differential diagnoses.Case report: Male, 8 years and 3 months, who came from another service with diagnosis of Precocious Puberty and Obesity, already being treated with Leuprolide acetate for 1 year and half. His compla...

hrp0086p2-p436 | Gonads & DSD P2 | ESPE2016

Mixed Gonadal Disgenesia: Patients of Instituto da Criança, HC-FMUSP

Ferreira Marianna , Pinheiro Claudia , Queiroz Edjane , Brigatti Nathalia , Ito Simone , Steinmetz Leandra , Cominato Louise , Setian Nuvarte , Dichtchekenian Vae , Filho Hamilton Menezes , Manna Thais Della , Damiani Durval

Background: Mixed gonadal dysgenesis (MGD) is a heterogeneous group of gonadal, chromosomal and phenotypic abnormalities. The diagnosis is based on the presence of testicular tissue and streak.Objective and hypotheses: Casuistics description of patients with MGD in our hospital.Method: A retrospective analysis of medical records.Results: We studied 15 patients. The age at first visit ranged from two weeks to ...

hrp0086p1-p471 | Fat Metabolism and Obesity P1 | ESPE2016

Improved Clinical and Laboratory Changes after 12 Months of Use of Metformin in Obese Insulin Resistant Children and Adolescents

Cominato Louise , Rocha Ruth , Renie Oliveira Rachid Ludmilla , Filgueiras Vilaca Duarte Nathalia , Cinquini Freitas Franco Natalia , Ybarra Marina , Steinmetz Leandra , Damiani Durval

Background: Childhood obesity is one of the most prevalent and challenging health care concerns. In this context, insulin resistance (IR) is an important disorder with strong association with metabolic (type 2 diabetes, hypercholesterolemia) and cardiovascular (hypertension, atherosclerosis) outcomes. Clinical trials have been showing Metformin as an effective drug on reducing the IR and BMI. However, there is little data on use of metformin in children....