hrp0089p3-p333 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P3 | ESPE2018

Young Male Adolescent with Gender Dysphoria (GD)/Gender Incongruence – A Case Presentation

Vlachopapadopoulou Elpis-Athina , Dikaiakou Eirini , Karagianni Stavroula , Michalacos Stefanos

Background: Children and adolescents who have a gender identity that does not correlate with their assigned gender (based upon genital anatomy and chromosomes) are described as Gender-Dysphoric/Gender-Incongruent Persons (GD/gender incongruence) based on the ICD-11 classification of the World Health Organization.Objective: The case of a young teenager with Gender Dysphoria Disorder.Case presentation: A boy, aged 13 and 4/12 years, ...

hrp0095p1-13 | Adrenals and HPA Axis | ESPE2022

Clinical characteristics and pubertal development in Greek girls with premature adrenarche.

Athina Vlachopapadopoulou Elpis , Dikaiakou Eirini , Kosteria Ioanna , Athanasouli Fani , Kafetzi Maria , Michalacos Stefanos

Background: Premature adrenarche (PA) is characterized by the appearance of pubic and axillary hair associated with an increase in adrenal androgen production, in the absence of central puberty, steroidogenic enzyme defects, or virilizing tumors, before the age of 8 years in girls and 9 years in boys. Studies have shown increased likelihood of PA for children with obesity and those born small for gestational age (SGA).Aim:</stron...

hrp0092p3-102 | Fat, Metabolism and Obesity | ESPE2019

Obesity and Insulin Resistance: Differences Between Pubertal and Prepubertal Children

Dikaiakou Eirini , Vlachopapadopoulou Elpis-Athina , Athanasouli Fani , Stergiotis Stefanos , Kafetzi Maria , Fotinou Aspasia , Michalakos Stefanos

Introduction: The presence of insulin resistance in obese children is strongly related to severity of obesity. Furthermore, insulin resistance is exacerbated during puberty, mainly due to increased sex steroids and growth hormone secretion.Objective: To compare obesity and insulin resistance indicators between pre-adolescent and adolescent children.Methods: 54 pre-adolescent and 41...

hrp0089p3-p392 | Thyroid P3 | ESPE2018

Hashitoxicosis:a Rare Diagnosis in Childhood

Vlachopapadopoulou Elpis Athina , Stergiotis Stefanos , Dikaiakou Eirini , Kafetzi Maria , Vakaki Marina , Fotinou Aspasia , Michalacos Stefanos

Aim: To highlight the diagnosis of Hashitoxicosis and its distinction from Graves’s disease. Subjects with Hashimoto’s thyroiditis are often euthyroid or may experience subclinical or true hypothyroidism. However, in 5 to 10% of children, a transient phase of hyperthyroidism, called Hashitoxicosis, may occur.Patients-Methods: Three female patients, were referred at the ages of 61/12, 96/12 and 12...

hrp0086p2-p423 | Gonads &amp; DSD P2 | ESPE2016

Sisters with 46XY Gonadal Dysgenesis and Gonadoblastoma

Petychaki Foteini , Vlachopapadopoulou Elpis , Dikaiakou Eirini , Mpaka Margarita , Kitsiou-Tzeli Sofia , Mavrou Ariadni , Michalakos Stefanos

Background: 46XY DSD with female phenotype is classified as complete gonadal dysgenesis (46XY CGD) if a uterus is present or a disorder of androgen synthesis or action if a uterus is absent. The genetic causes of 46XY CGD are not fully clarified. Less than 15% of the cases were found to carry mutations of the sex determining region Y gene (SRY).Purpose: The description of the rare case of two sisters affected of 46XY CPD and gonadoblastoma with SRY mutat...

hrp0084p3-633 | Autoimmune | ESPE2015

Hypercalcaemia as an Indication of Adrenal Insufficiency in a Patient with Autoimmune Polyendocrinopathy–Candidiasis–Ectodermal Dystrophy

Dikaiakou Eirini , Vlachopapadopoulou Elpida-Athina , Anagnostou Elli , Panagiotopoulos Ioannis , Photinou Aspasia , Michalacos Stephanos

Background: Autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy (APECED), is a rare inherited disease of childhood, caused by the mutation of the AIRE gene on chromosome 21. It is characterized by three main diseases: chronic mucocutaneous candidiasis (CMC), chronic hypoparathyroidism (HP), and Addison’s disease (AD), and can be associated with other autoimmune diseases and/or manifestations of ectodermal dystrophy.Case...

hrp0094p2-401 | Sex differentiation, gonads and gynaecology or sex endocrinology | ESPE2021

Two sisters with primary hypergonadotrophic hypogonadism, pubertal progress and deletion of 61.5MB of Χq21.33q28 region

Dikaiakou Eirini , Vlachopapadopoulou Elpis Athina , Papoulidis Ioannis , Manolakos Emannouil , Vakaki Marina , Michalacos Stefanos

Objective: To present the novel finding of hypergonadotropic hypogonadism, pubertal progress and molecular alterations in two sisters with variable phenotype.Case Presentation: Two Greek sisters were investigated. The eldest was referred for investigation of short stature, at the age of 9 and 5/12 years. There was no positive family history for short stature. Physical examination revealed no dysmorphic features, and she was prepubertal according to Tanne...

hrp0094p2-38 | Adrenals and HPA Axis | ESPE2021

Addison’s disease: Delay in diagnosis in a girl with longstanding symptoms

Vlachopapadopoulou Elpis Athina , Bonataki Myrto , Dikaiakou Eirini , Fakiolas Stefanos , Kafetzi Maria , Michalacos Stefanos ,

Background: Autoimmune destruction of the adrenal cortex is the cause of primary adrenal insufficiency in 45% to 55% of cases in children.Case presentation: A 10-year and 10-month-old female was admitted to the Pediatric Endocrinology Clinic for evaluation of suspected adrenal insufficiency. The girl reported longstanding complaints of fatigue, loss of appetite, recurrent gastric symptoms and salt craving. Medical history was significant...

hrp0094p2-360 | Pituitary, neuroendocrinology and puberty | ESPE2021

In vivo magnetic resonance spectroscopy as a non-invasive tool for the identification of a sellar tumour in a boy with precocious puberty.

Kosteria Ioanna , M. Gavra Maria , Vlachopapadopoulou Elpis-Athina , A. Verganelakis Dimitrios , Dikaiakou Eirini , Vartzelis Georgios , Michalakos Stefanos ,

Aim: To highlight the role of in-vivo magnetic resonance spectroscopy (MRS), as a non-invasive tool that can clarify the specific etiology of a sellar tumour in a boy with precocious puberty.Case presentation: A 4-year-old boy was admitted due to repeated episodes of focal seizures with fixed gaze, head turn to the right, and postictal drowsiness. Parents reported episodes of inappropriate laughter ("gelastic seizures") in the pr...

hrp0097p1-497 | GH and IGFs | ESPE2023

First-year response to growth hormone (rGH) treatment and assessment of iGRO software for the prediction of growth velocity.

Kosteria Ioanna , Atnanasouli Fani , Dikaiakou Eirini , Leka-Emiris Sofia , Vlachopapadopoulou Elpis-Athina

Objectives: Response to rGH during the first year of treatment is considered indicative of its effectiveness for the improvement of final height. The iGRO software assesses the response to rGH in children with idiopathic growth hormone deficiency (IGHD) or small for gestational age (SGA) based on age, gender, gestational age, birthweight, rGH dose, maximal GH during stimulation tests, as well as weight and height measurements on follow-up visits. The aim was t...