ESPE Abstracts

Background: Recently, patients with severe obesity have been described due to functional leptin deficiency. This new entity is characterized by high immunoreactive levels of circulating leptin (Lep), but a reduced bioactivity of the hormone due to defective receptor binding (N Engl J Med 2015;372:48–54). Since these patients can be successfully treated with human recombinant leptin (metreleptin), a diagnostic tool to detect functional leptin deficiency is needed.<p cl...

Background: Severe early-onset obesity (SEOO) in children is more frequently observed in subjects with genetic disorders of which those of leptin pathway can be analyzed biochemically and genetically.Objectives: The aim of the study was to investigate anthropometrics and leptin parameters, specifically searching for bio-inactive leptin, in children with SEOO.Methods: Study cohort includes children ...

Introduction: The soluble leptin receptor (sLR) is the main binding protein of leptin in the serum. It reflects the amount of membrane-bound leptin receptors (LEPR) as the sLR is produced by proteolytic cleavage of the extracellular domain of membrane-bound LEPR. Low sLR but high leptin levels were measured in patients with severe obesity. In patients with monogenic obesity caused by biallelic LEPR variants, sLR levels were found to be either undetect...

Background: Current reference values for leptin in childhood and adolescence are presented separately for girls and boys, and as a function of age without considering the variability of fat mass. This complicates the interpretation of measured serum leptin concentrations since fat mass is the major determinant of circulating leptin concentrations. To fill this gap, we aimed at pooling existing data (age, BMI, sex, tanner stage (TS), serum leptin concentrations...

Background: Obesity is increasingly being diagnosed in the paediatric population. Obesity during childhood and adolescents is related to an increased risk for cardiovascular diseases, high blood pressure, diabetes mellitus and menstrual disorders including heavy menstrual bleeding, oligomenorrhea, dysmenorrhea. The study aim: is to investigate the incidence of menstrual disorders in adolescents with severe obesity. <...

Aim: Childhood obesity has become extremely important issue worldwide. The aim of this study was to determine associations between data from bioimpedance analysis with the antrophometric measurements and biochemical results obtained from children and adolescents with severe obesity.Study population and Methods: Study group consisted of 128 children recruited in four regional reference centers including 70 girls (54.7%) a...

It is estimated that 1-5% of children and adolescents in Europe suffer from severe obesity (corresponding to an adult BMI > 40 kg/m2). However, in risk stratification, the occurrence of metabolic complications is more important than BMI itself. The study aimed to assess the occurrence of cardiovascular risk factors in a cohort of children and adolescents with severe obesity.Patients and Methods: The analysis included 140 patients (75 ...

Background: Fatty liver disease in children and adolescents is the most common cause of chronic liver disease in many countries. Criteria for a diagnosis of pediatric metabolic associated fatty liver disease (MAFLD) are based on hepatic steatosis in ultrasound, blood biomarkers or liver biopsy in association with one of the three criteria: excess adiposity (overweight, obesity or abdominal obesity), prediabetes or type 2 diabetes, or evidence of metabolic dysr...

Aims: The aimof this study was to investigate the prevalence and risk factors of MAFLD in severely obese polish children and adolescents.Patients and Methods: Data were collected in four Polish medical centers as a part of the project "Prevalence of monogenic obesity among Polish children and adolescents with severe obesity" (funded by National Science Center, Poland (2021/41/B/NZ5/01676)). Inclusion criteria f...

Severe early-onset obesity (SEOO) increases the likelihood of obesity persisting into adulthood. Leptin (LEP), a hormone primarily produced in adipose tissue, plays a crucial role in regulating energy balance. When assessing young children with SEOO, it is important to consider abnormalities in the leptin-melanocortin pathway. Our study aim ed to identify children with SEOO who may have LEP deficiency or biologically inactive leptin by analyzing leptin and biologically active ...