hrp0095p1-13 | Adrenals and HPA Axis | ESPE2022

Clinical characteristics and pubertal development in Greek girls with premature adrenarche.

Athina Vlachopapadopoulou Elpis , Dikaiakou Eirini , Kosteria Ioanna , Athanasouli Fani , Kafetzi Maria , Michalacos Stefanos

Background: Premature adrenarche (PA) is characterized by the appearance of pubic and axillary hair associated with an increase in adrenal androgen production, in the absence of central puberty, steroidogenic enzyme defects, or virilizing tumors, before the age of 8 years in girls and 9 years in boys. Studies have shown increased likelihood of PA for children with obesity and those born small for gestational age (SGA).Aim:</stron...

hrp0089p2-p056 | Bone, Growth Plate &amp; Mineral Metabolism P2 | ESPE2018

First Reported Cases of a Novel Variant of GNAS 1 Gene

Fafoula Olga , Panagiotakou Argyro , Grivas Grigorios , Fryssira Eleni , Kosteria Ioanna , Korovessi Paraskevi , Kostaridou Stavroula

Background: GNAS 1 gene (guanine nucleotide binding protein, alpha stimulating) encodes the alpha subunit of the stimulatory guanine nucleotide-binding protein (G-protein). Variations in the GNAS 1 can cause several disorders including Pseudohypoparathyroisism Type 1A (PHP1A), Type 1B (PHP1B), Type 1C (PPHP1C), Progressive Osseous Heteroplasia (POH), Pseudopseudohypoparathyroidism (PPHP) and McCune-Albright syndrome (MAS).Objectives: To report 2 patients...

hrp0086rfc13.2 | Management of Obesity | ESPE2016

The Use of Proteomics in the Assessment of Health Status of Offspring Born after Intracytoplasmic Sperm Injection (ICSI)

Kosteria Ioanna , Gkourogianni Alexandra , Papadopoulou Aggeliki , Anagnostopoulos Athanasios , Chrousos George , Tsagaris George , Kanaka-Gantenbein Christina

Background: Several studies have correlated Assisted Reproduction Technologies (ART) including classic IVF and Intacytoplasmic Sperm Injection (ICSI) with epigenetic alterations in the offspring that could have long lasting unfavorable metabolic effects. Proteomics, a state-of-the-art technology used for the identification of early biomarkers of disease, has already been implemented in the search of success in ART but not yet for such markers evaluation in offspring of ART.</p...

hrp0094p2-360 | Pituitary, neuroendocrinology and puberty | ESPE2021

In vivo magnetic resonance spectroscopy as a non-invasive tool for the identification of a sellar tumour in a boy with precocious puberty.

Kosteria Ioanna , M. Gavra Maria , Vlachopapadopoulou Elpis-Athina , A. Verganelakis Dimitrios , Dikaiakou Eirini , Vartzelis Georgios , Michalakos Stefanos ,

Aim: To highlight the role of in-vivo magnetic resonance spectroscopy (MRS), as a non-invasive tool that can clarify the specific etiology of a sellar tumour in a boy with precocious puberty.Case presentation: A 4-year-old boy was admitted due to repeated episodes of focal seizures with fixed gaze, head turn to the right, and postictal drowsiness. Parents reported episodes of inappropriate laughter ("gelastic seizures") in the pr...

hrp0097p1-497 | GH and IGFs | ESPE2023

First-year response to growth hormone (rGH) treatment and assessment of iGRO software for the prediction of growth velocity.

Kosteria Ioanna , Atnanasouli Fani , Dikaiakou Eirini , Leka-Emiris Sofia , Vlachopapadopoulou Elpis-Athina

Objectives: Response to rGH during the first year of treatment is considered indicative of its effectiveness for the improvement of final height. The iGRO software assesses the response to rGH in children with idiopathic growth hormone deficiency (IGHD) or small for gestational age (SGA) based on age, gender, gestational age, birthweight, rGH dose, maximal GH during stimulation tests, as well as weight and height measurements on follow-up visits. The aim was t...

hrp0095p2-96 | Fat, Metabolism and Obesity | ESPE2022

SGPT and FT4 correlations among Greek school age children with obesity or severe obesity

Leka-Emiri Sofia , Kosteria Ioanna , Vlachopapadopoulou Elpis , Dikaiakoy Eirini , Evangelopoulou Catherine , Kafetzi Maria , Petrou Vasilios , Michalacos Stefanos

Background/Aims: Pediatric obesity remains an ongoing serious international health concern. Whether liver dysfunction is related to thyroid dysfunction in this population is controversial. Compare SGPT, TSH, FT4 and insulin resistance indexes between children with obesity or severe obesity.Methods: 279 children (143 females) with ΒΜΙ (≥95percentile) (CDC BMI curves) were divided in two groups (Group 1, ob...

hrp0089p1-p048 | Diabetes &amp; Insulin P1 | ESPE2018

Menstrual Cycle Disorders in Young Women with Type 1 Diabetes Mellitus

Paschou Stavroula A , Vryonidou Andromachi , Melissourgou Marina , Kosteria Ioanna , Anagnostis Panagiotis , Goulis Dimitrios G , Chrousos George P , Kanaka-Gantenbein Christina

Background and aim: Epidemiologic observations suggest that women with type 1 diabetes mellitus (T1DM) often suffer from menstrual cycle disorders. There may also be a negative association between the age of onset of T1DM and the age of menarche. Delayed menarche, in turn, may be associated with increased risk for diabetic complications. The aim of this study was to prospectively investigate pathologic manifestations of reproductive function in young women with T1DM and their ...

hrp0086p2-p270 | Diabetes P2 | ESPE2016

Seasonality of Type 1 Diabetes in Children and Adolescents According to Date of Diagnosis and Date of Birth in a Large Diabetes Centre

Vasilakis Ioannis Anargyros , Kosteria Ioanna , Tzifi Flora , Christopoulos-Timogiannakis Evangelos , Kotrogianni Paraskevi , Chrousos George , Kanaka-Gantenbein Christina

Background: There are studies supporting the seasonality of diabetes according to date of diagnosis and date of birth, with most T1D children being diagnosed in fall and winter and most of them been born in the same period. That is in concordance with previously published data from 1978 to 2008 in our country.Objective and hypotheses: To assess whether there is a seasonal variation of diabetes onset according to date of diagnosis and date of birth of inc...

hrp0086p2-p293 | Diabetes P2 | ESPE2016

Impact of Demographic Factors on Diabetic Ketoacidosis Occurrence at Type 1 Diabetes Onset in Childhood

Tzifi Flora , Kosteria Ioanna , Vasilakis Ioannis Anargyros , Christopoulos-Timogiannakis Evangelos , Koutaki Diamanto , Chrousos George , Kanaka-Gantenbein Christina

Background: Diabetic Ketoacidosis (DKA) in newly diagnosed children with Type 1 Diabetes (T1D) has been associated in previous studies with several factors, such as age or season of diagnosis.Objective and hypotheses: The aim of the present study was to assess the impact of age, gender, birth order and seasonality in DKA occurrence in newly diagnosed T1D pediatric patients.Method: Data of children aged 0–14 years newly diagnos...

hrp0094p2-451 | Thyroid | ESPE2021

A girl with Trisomy 21 presents with Van Wyk-Grumbach syndrome. A rare diagnosis

Dikaiakou Eirini , Vlachopapadopoulou Elpis Athina , Kosteria Ioanna , Panos Alexandros , Dede Eirini , Koutrouveli Eleni , Zouridaki Christina , Michalacos Stefanos

Background: Van Wyk-Grumbach syndrome (VWGS) is a rare diagnosis that should be suspected in children with signs of peripheral precocious puberty and hypothyroidism. It is characterized by multicystic enlarged ovaries, in the presence of long-term severe hypothyroidism. Treatment of VWGS consists of hormonal replacement with levothyroxine. Usually, ovarian cysts and increased ovarian volume subside within an average of 2 months but can persist up to 12 months after treatment.<...