hrp0089p3-p093 | Diabetes & Insulin P3 | ESPE2018

Symptomatic Cerebral Infarction: A Rare Complication of Diabetic Ketoacidosis

Celmeli Gamze , Parlak Mesut , Akcurin Sema , Bircan Iffet

Diabetic ketoacidosis (DKA) is accompanied by intracerebral complications from 0.3% to 1%. Cerebrovascular events account for 10% of intracerebral complications. Our aim is to present a case of symptomatic cerebral infarction as a serious complication of DKA and draw attention to the management of DKA treatment. A 3.5-years-old male patient was referred to our department with DKA for further evaluation and treatment. Before coming to our center, insulin and sodium bicarbonate ...

hrp0084p1-111 | Puberty | ESPE2015

Serum Neurokinin B Level can be Used to Differentiate Central Precocious Puberty from Premature Thelarche

Parlak Mesut , Turkkahraman Doga , Ellidag Hamit Yasar , Parlak Ayse Eda

Background: Neurokinin B and kisspeptin appear to play main roles in puberty.Aims and objectives: The aim of the present study was to investigate the diagnostic role of kisspeptin and neurokinin B in central precocious puberty (CPP) and premature thelarche (PT).Methods: The girls who presented with breast development (between 5 and 8 years) were included in the study. All cases underwent bone age (BA) assesment. Basal serum FSH, LH...

hrp0084p2-180 | Adrenals | ESPE2015

High-Dose Hook Effect in 17- Hydroxyprogesterone Assay in 21-Hydroxylase Deficiency

Parlak Mesut , Turkkahraman Doga , Parlak Ayse Eda , Ellidag Hamit Yasar

Background: False-negative results can occur an extremely high level of substrate at the assay system. This is called the ‘high-dose hook effect’.Case presentation: 14 year-old female patient was referred with short stature, amenorea and hirsutism. Height, weight and blood pressure were 140.5 cm (SDS:−3.5), 43.4 kg (SDS:−1.6) and 120/80 mmHg. She had stage 1 Tanner breast, stage 5 pubic hair and hirsutism (mFG scale: 28) with androi...

hrp0082p3-d2-860 | Growth (3) | ESPE2014

Clinical Expression of Familial Williams–Beuren Syndrome in a Turkish Family

Parlak Mesut , Nur Banu Guzel , Mihci Ercan , Durmaz Erdem , Karauzum Sibel Berker , Akcurin Sema , Bircan Iffet

Background: WBS is a rare genetic disorder characterized by distinctive facial features, intellectual disability, cardiovascular anomalies, and infantile hypercalcemia.Objective and hypotheses: Majority of WBS cases occur sporadically, only five families with clinically confirmed WBS have been identified by molecular cytogenetic analysis. Here, we report on the three molecular cytogenetically confirmed familial WBS detected in a family with familial shor...

hrp0082p3-d2-893 | Perinatal and Neonatal Endocrinology (1) | ESPE2014

Severe Vitamin D Deficiency Among Pregnant Women and Their Newborns in Turkey

Parlak Mesut , Kalay Zuhal , Kirecci Ahmed , Guney Ozgur , Koklu Esad , Kalay Salih

Objectives: Vitamin D deficiency is an important health problem in pregnant women and their infants in sunny countries. The present study evaluated serum 25-hydroxyvitamin D3 (25(OH)D3) concentrations in pregnant women and in their newborns and determined the risk factors in LSES cities in Turkey.Methods: Ninety-seven pregnant women and their newborns were included in the study between December 2012 and February 2013. All of the pregnant women had irregu...

hrp0097p1-193 | Thyroid | ESPE2023

Thyroid hormone resistance syndrome due to a new mutation in the TRHA gene

Tuhan Hale , Donbaloğlu Zeynep , Kırbıyık Özgür , Parlak Mesut , Demir Korcan

Introduction: Resistance to thyroid hormones is defined as lack of response of peripheral tissues to triiodothyronine (T3) which is the active form of thyroid hormones. In general (85%) a mutation is detected in the thyroid hormone receptor β (THRB) gene and more rarely, the thyroid hormone receptor α (TRHA) gene.Case: A 4.7-year-old boy, was admitted to the pediatric endocrinology outpatient clinic of Akdeniz...

hrp0095p1-300 | GH and IGFs | ESPE2022

Evaluation of the growth response of children with growth hormone deficiency according to peak growth hormone levels on provocative tests

Donbaloğlu Zeynep , Singin Berna , Acar Sezer , Bedel Aynur , Barsal Çetiner Ebru , Aydin Behram Bilge , Parlak Mesut , Tuhan Hale

Objective: We aimed to evaluate the relation between the peak growth hormone (GH) levels on provocative tests and response to recombinant human GH (rhGH) therapy in patients with GH deficiency (GHD).Methods: This was a cross-sectional, single-center, and retrospective study. A total of 518 patients who received rhGH therapy under the age of 16 in the Endocrinology Clinic of Akdeniz University Hospital between 1997 and 20...

hrp0095p1-155 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Evaluation of the influence of the gonadotropin-releasing hormone agonist therapy on growth and body mass index in girls with idiopathic central precocious puberty

Donbaloğlu Zeynep , Bedel Aynur , Barsal Çetiner Ebru , Singin Berna , Aydın Behram Bilge , Tuhan Hale , Parlak Mesut

Objective: We aimed to examine the auxological findings of the girls diagnosed with idiopathic central precocious puberty (CPP) at the end of the Gonadotropin-releasing hormone analogs (GnRHa) treatment and to investigate the effect of related factors on the height gain of those patients.Methods: This study was designed as single-center, descriptive, cross-sectional retrospective study. A total of 43 patients who were di...

hrp0097p1-419 | Bone, Growth Plate and Mineral Metabolism | ESPE2023

Evaluation of the pediatric patients diagnosed with secondary osteoporosis

Singin Berna , Donbaloğlu Zeynep , Barsal Çetiner Ebru , Aydın Behram Bilge , Ünver Tuhan Hale , Parlak Mesut

Objective: Secondary osteoporosis has a high rate of accompanying chronic diseases. We aimed to review the clinical and laboratory features, underlying causes, Dual Energy X-ray Absorptiometry (DEXA) results before and after treatment of patients diagnosed with secondary osteoporosis and to determine the relationship between this condition and fracture rates.Methods: This study was designed as a single-center, descriptiv...

hrp0097p1-358 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Do gonadotropin releasing hormone analogues increase the total body fat mass and body mass index in girls with idiopathic central precocious puberty?

Donbaloğlu Zeynep , Singin Berna , Barsal Cetiner Ebru , Aydin Behram Bilge , Bedel Aynur , Tuhan Hale , Parlak Mesut

Aim: Gonadotropin-releasing hormone analogues (GnRHa) are widely used in the treatment of idiopathic central precocious puberty (ICPP) cases due to premature maturation of the hypothalamus-pituitary-gonad axis. The effect of GnRHa therapy on body weight and fat distribution is controversial in the literature. We aimed to examine the anthropometric measurements and body composition analysis of the girls with ICPP and to investigate the effect of related factors...