hrp0082p3-d1-974 | Thyroid | ESPE2014

Increasing Incidence of Congenital Hypothyroidism in Neonatal Screening Program in Central Serbia: 30 Years of Experience

Milenkovic Tatjana , Opancina Branka , Mitrovic Katarina , Todorovic Sladjana , Vukovic Rade

Background: Neonatal TSH screening program for congenital hypothyroidism (CH) in Central Serbia was introduced in 1983. Over the past three decades, increasing overall incidence rate of children with both permanent and transient forms of CH has been observed.Objective and hypotheses: The aim of the study was to compare incidence of CH in the first 16 years of screening (period 1) with the last 15 years of screening (period 2). We also investigated the im...

hrp0082p3-d2-991 | Thyroid (1) | ESPE2014

Missed Cases of Congenital Hypothyroidism Detected By Screening Program in Central Serbia (1983–2014)

Todorovic Sladjana , Milenkovic Tatjana , Zdravkovic Dragan , Mitrovic Katarina , Vukovic Rade

Background: There are a lot of reasons for missing the diagnosis in neonatal screening for congenital hypothyroidism (CH), but errors in processing samples and reporting results are the most frequent! In Central Serbia screening for CH was instituted in 1983 by determination of the TSH level in dried filter-paper blood spots. All samples are analyzed at one central laboratory. The average number of specimens that are annually screened is 50 000. The screening process was divid...

hrp0092p1-369 | GH and IGFs (2) | ESPE2019

Detection and Referral of Children with Short Stature in Serbia - the Impact of Electronic Growth Charts

Panic Sanja , Rade Vukovic , Milenkovic Tatjana , Mitrovic Katarina , Todorovic Sladjana , Soldatovic Ivan

Introduction: in countries with highly developed health information systems (HIS), early detection of short stature (SS) is facilitated by automated anthropometric calculations, with warning alarms and automated referrals when prespecified conditions are met (poor growth velocity etc.). In countries where available HIS resources are insufficient for implementation of complex automated systems for growth supervision, much simpler, graphical-based growth electro...

hrp0089p2-p127 | Fat, Metabolism and Obesity P2 | ESPE2018

Pediatric Continuous Metabolic Syndrome Score (PsiMS score): Use in Everyday Clinical Practice

Vukovic Rade , Soldatovic Ivan , Milenkovic Tatjana , Mitrovic Katarina , Todorovic Sladjana , Plavsic Ljiljana

Introduction: Dichotomous nature of current definition of metabolic syndrome (MS) in youth results in loss of information. On the other hand, the complex calculation of continuous MS scores using standardized residuals in linear regression (Z scores) or factor scores of principal component analysis (PCA) is demanding and highly impractical for clinical use. Recently, a novel, easily calculated continuous MS score called Pediatric siMS score (PsiMS score) was developed based on...

hrp0089p2-p302 | Pituitary, Neuroendocrinology and Puberty P2 | ESPE2018

Triptorelin Test in Idagnosing Central Precocious Puberty

Vukovic Rade , Milenkovic Tatjana , Mitrovic Katarina , Todorovic Sladjana , Plavsic Ljiljana , Soldatovic Ivan

Introduction: GnRH test is standard in confirming the diagnosis of central precocious puberty (CPP). However, GnRH (Relefact) is not always readily available in Serbia and several other countries. Two studies so far have assessed use of triptorelin in diagnosing CPP, with different sampling protocols, and in only one of these studies were triptorelin test findings compared to GnRH test findings.Objective: To evaluate the diagnostic accuracy of triptoreli...

hrp0086p1-p219 | Diabetes P1 | ESPE2016

Impact of Continuous Glucose Monitoring System on Therapy of Cystic Fibrosis Related Diabetes in Children and Young Adults

Todorovic Sladjana , Milenkovic Tatjana , Minic Predrag , Mitrovic Katarina , Sovtic Aleksandar , Rodic Milan , Vukovic Rade , Plavsic Ljiljana

Background: Cystic fibrosis related diabetes (CFRD) is one of the most common complications of CF. CFRD has great impact on progressive deterioration of lung function, poor growth and increased mortality. The need for early detection of disturbance in glucose metabolism was recognized long ago. Current recommendations include screening that begins at age of 10 by performing oral glucose tolerance test (OGTT) but it cannot reveal the initial glucose disturbances. Many centres a...

hrp0084p3-602 | Adrenals | ESPE2015

The First Case of Primary Generalized Glucocorticoid Resistance in Serbia in an 8-Year-Old Boy with G679S Mutation of the NR3C1 Gene

Mitrovic Katarina , Vukovic Rade , Milenkovic Tatjana , Todorovic Sladjana , Plavsic Ljiljana , Zdravkovic Dragan

Background: Primary generalized glucocorticoid resistance (PGGR) is a rare genetic condition characterised by generalised, partial target-tissue insensitivity to glucocorticoids owing to inactivating mutations of the NR3C1 gene.Case presentation: An 8.5-year-old boy was hospitalized because of precocious puberty and arterial hypertension. Over the last year, the appearance of pubic hair and gynecomastia were noted. At the local centre, high leve...

hrp0095p1-18 | Adrenals and HPA Axis | ESPE2022

Very early and atypical presentation of Triple A (Allgrove) syndrome

Cehic Maja , Kovacevic Gordana , Milenkovic Tatjana , Kravljanac Ruzica , Todorovic Sladjana , Vukovic Rade , Panic-Zaric Sanja , Katarina Mitrovic

Background: Triple A (Allgrove syndrome) is a rare, autosomal recessive disorder characterized by the alacrimia, achalasia, and adrenal insufficiency triad. Alacrimia starts in early infancy, while achalasia and adrenal insufficiency appear subsequently during childhood or adulthood. We are presenting an infant with very early and simultaneous clinical manifestations of triple A syndrome.Case presentation: An 11-month-ol...

hrp0095p2-14 | Adrenals and HPA Axis | ESPE2022

The first case of pediatric Cushing disease in Serbia

Panic Zaric Sanja , Vukovic Rade , Milenkovic Tatjana , Mitrovic Katarina , Todorovic Sladjana , Ristic Snezana , Stajic Natasa , Putnik Jovana , Paripovic Aleksandra , Vukomanovic Vladislav , Ninic Sanja , Prijic Sergej , Popovic Sasa , Cerovic Ivana , Kitic Ivana , Pasic Srdjan , Minic Predrag , Rodic Milan , Kuzmanovic Milos , Jovic Milena , Djordjevic Milosevic Maja , Pekic Djurdjevic Sandra , Petakov Milan , Milicevic Mihajo , Jovanovic Milan

Background: The definition of Cushing disease (CD) is hypercortisolism caused by excess adrenocorticotropic hormone (ACTH) secretion by a pituitary corticotrope adenoma. It is extremely rare in the pediatric population and requires rapid diagnosis and early management.Case presentation: A 14-year old boy was hospitalized because of sudden onset of chest pain, loss of consciousness, elevated cardio-specific enzymes, and s...

hrp0092p1-157 | Adrenals and HPA Axis (1) | ESPE2019

Influence of Salt Supplementation on Drug Therapy in Children with Congenital Adrenal Hyperplasia (CAH) Due to 21-Hydroxylase Deficiency Aged 0-3 Years: Update on a Retrospective Multicentre Analysis Using the I-CAH Registry

Neumann Uta , van der Linde Annelieke , Krone Ruth , Guven Ayla , Güran Tülay , Elsedfy Heba , Darendeliler Feyza , Bachega Tania , Balsamo Antonio , Hannema Sabine , Birkebaek Niels , Vieites Ana , Acerini Carlo , Cools Martine , Milenkovic Tatjana , Bonfig Walter , Costa Eduardo , Atapattu Navoda , de Vries Liat , Filho Guilherme , Korbonits Marta , Mohnike Klaus , Bryce Jillian , Ahmed Faisal , Voet Bernard , Blankenstein Oliver , van der Grinten Hedi Claahsen

Introduction: Classic congenital adrenal hyperplasia (CAH) caused by 21-hydroxylase deficiency results in impaired synthesis of gluco- and often also of mineralocorticoids. Early treatment with glucocorticoids and mineralocorticoids prevents life-threatening crises. In some centres, additional salt is prescribed in the first year. However, until now the use of salt is controversial and not proved to result in better outcome in studies.<s...