hrp0082p2-d3-352 | Diabetes (2) | ESPE2014

Socioeconomic Deprivation is Associated with Increased Hospital Admissions in Children with Type 1 Diabetes Mellitus

Apperley Louise , Ng Sze May

Background: Socioeconomic deprivation is an important determinant of health.Objectives: This study examined the relationship between incidence of hospital admissions for patients with Type 1 diabetes mellitus (T1DM) and their socioeconomic deprivation.Methods: All hospital admissions of patients with T1DM from 0 to16 years were identified during a 5-year period between 2007 and 2012 using the hospital episodes statistics database (...

hrp0082p2-d3-353 | Diabetes (2) | ESPE2014

Household Unemployment and Low Levels of Education are Associated with Poor Glycaemic Control in Children and Young People with Type 1 Diabetes Mellitus

Apperley Louise , Ng Sze May

Background: Socioeconomic deprivation, obesity and emotional well-being are important determinants of health inequalities and poor glycaemic control in adults with type 1 diabetes mellitus (T1DM).Objectives: This study aims to look at the effect of social deprivation, BMI and patient reported emotional well-being on glycaemic control in children and young adults with T1DM.Methods: Socioeconomic status was measured by cross-referenc...

hrp0086p2-p961 | Thyroid P2 | ESPE2016

Profound Growth Failure in Peripubertal Adolescents Presenting with Severe Acquired Autoimmune Hypothyroidism: A Case Series

Upadrasta Swathi , Soni Astha , Ng Sze May

Background: Children with severe hypothyroidism are known to present with significant growth restriction. Institution of treatment with thyroxine (T4) results in catch-up growth. However, treatment commenced in pubertal period may result in loss of adult height in cases with longstanding severe hypothyroidism.Objective and hypotheses: The objective of our study is to evaluate the presentation, investigations and catch-up growth after initiatio...

hrp0082p2-d1-323 | Diabetes | ESPE2014

Improving Paediatric Diabetes Care with the Use of an Electronic Diabetes Information Management System (Twinkle.Net) and Routine Uploading of Blood Glucose Meters and Insulin Pumps (Diasend) in Outpatient Clinic

Ng Sze May , Connellan Linda , Finnigan Lynne

Background: The UK has the highest number of children and young people with type 1 diabetes mellitus in Europe, but the lowest number of children and young people attaining good diabetes control.Methods: In December 2012, our diabetes service established the use of an electronic diabetes information management system that was web-based (Twinkle.Net) and routine uploading of glucose meters and pumps (Diasend). The electronic management system Twinkle.Net ...

hrp0084p3-703 | Diabetes | ESPE2015

A 1-year Follow-up Study to Evaluate Efficacy and Compliance of Continuous Glucose Monitoring in Children with Type 1 Diabetes Mellitus

Soni Astha , Clemente Marisa , Ng Sze May

Background: Self monitoring of blood glucose (SMBG) is an important part of diabetes management. Continuous glucose monitoring system (CGMS) provides the real time measurements of users’ glucose levels. The NICE guideline recommends use of CGMS if there is persistent hypoglycaemia unawareness or repeated hypoglycaemia or hyperglycaemia. In our paediatric diabetes clinic within a large DGH, we have a cohort of 12 children who were funded for the CGM use for a minimum of 1 ...

hrp0092p1-314 | Diabetes and Insulin (2) | ESPE2019

Comparison Between Patients and Families who Routinely Download Data and Those who do Not Download Data at Home in The Management of Type 1 Diabetes

Ng Sze May , Sultana Perveen , Clemente Marisa , Apperley Louise

Background: In type 1 diabetes (T1D), optimal glycaemic control requires intensive self-management to reduce the risk of complications. While routine downloading and review of blood glucose data is part of clinical practice of healthcare providers in an outpatient setting, patients and families are also educated, advised and encouraged to regularly download and review blood glucose data at home in order to make adjustments to insulin dosing for carbohydrate in...

hrp0082p2-d2-330 | Diabetes (1) | ESPE2014

A Multicentre Study Evaluating the Risk and Prevalence of Diabetic Retinopathy in Children and Young People with Type 1 Diabetes Mellitus

Ng Sze May , Ayoola Omolola O , McGuigan Michael , Chandrasekaran Surendran

Background: There is currently limited data published on the prevalence of diabetic eye disease in children and young people (CYP) with type 1 diabetes mellitus (T1DM), yet diabetic retinopathy remains one of the commonest causes of blindness in young adults.Objectives: To determine the risk and prevalence of diabetic retinopathy and to evaluate the risk factors associated with diabetic retinopathy in CYP with T1DM.Methods: All CYP...

hrp0082p2-d3-509 | Perinatal and Neonatal Endocrinology | ESPE2014

Neonatal Pituiiary–Thyroid Axis Dysregulation with Combined Thyroid Hormone and TSH Resistance in Infant with Trisomy 21 and Maternal Subclinical Hypothyroidism

Soni Astha , Avula Shivaram , Didi Mohammed , Ng Sze May

Background: Trisomy 21 is associated with dysregulated pituitary thyroid axis with higher TSH and lower FT4 than controls. This may be due to genomic imbalance from trisomy of chromosome 21. Transient congenital hypothyroidism (CH) in newborns is recognised in association with maternal thyroperoxidase (TPO) antibody positivity. ‘Thyroid hormone resistance’ in infancy in CH is also been described.Objective and hypotheses: We report an...

hrp0084fc12.5 | Obesity - Clinical | ESPE2015

Link Between BMI and Insulin Requirement in Children and Young People with Type 1 Diabetes Mellitus

Upadrasta Swathi , Finnigan Lynne , Connellan Linda , Ng Sze May

Background: Prevalence of being overweight or obese is increasing in type 1 diabetes mellitus (T1DM). The recent UK National Paediatric Diabetes Audit (NPDA) 2013/14 reported that 36.6% of 0–11 year old children and 43.9% of 12 years and older children are currently overweight or obese. Childhood obesity in T1DM predicts long-term risk of adult diabetes complications. Previous studies have shown significant positive correlation between HbA1c and total insulin requirement ...

hrp0084p3-1147 | Puberty | ESPE2015

Persistent Isolated Cyclical Vaginal Bleeding (Premature Menarche) not Associated with GnRH Pubertal Response or Endometrial Echo Should be Considered for Examination Under General Anaesthesia

Upadrasta Swathi , Watson Lauren , Natarajan Anuja , Ng Sze May

Background: Isolated prepubertal menarche is described in the absence of any other signs of precocious sexual development. This condition remains unclear in its aetiology and there is currently no consensus on investigations to be undertaken.Objective and hypotheses: The objective of our study is to evaluate the following factors associated with persistent isolated cyclical vaginal bleeding: clinical presentation, gonadotrophin-releasing hormone (GnRH) s...