hrp0092p2-28 | Bone, Growth Plate and Mineral Metabolism | ESPE2019

Clinical Radiographic and Biochemical Findings of Three Patients with Hypophosphatasia Carrying the Same Mutation

Orbak Zerrin , Orbak Recep

Background: Hypophosphatasia (HP) is a rare inherited disorder characterized by defective bone and tooth mineralization and caused by deficiency in the tissue non-specific alkaline phosphatase gene (ALPL). The symptoms are remarkably variable in their clinical expression, and relate to numerous mutations in this gene.Aim: The purpose of this study was to document the clinical, biochemical and radiologic aspects of the th...

hrp0089p3-p169 | Fat, Metabolism and Obesity P3 | ESPE2018

Comparison of the Effectiveness of a Battery Powered and Manual Toothbrush in Removal of a Dental Plaque for Good Oral Hygiene in Adolesents with Over-Weight

Orbak Recep , Orbak Zerrin

Objective: Dental plaque removal is an important factor in preventing periodontal diseases and caries. Tooth brushing remains the most reliable method of controlling dental plaque. The purpose of this study was to compare the effectiveness of plaque control performed with a battery powered and manual toothbrushes in over-weight adolescents.Materials and methods: The twenty two adolesents with over-weight were attended in this study. These patients were d...

hrp0086p2-p571 | Perinatal Endocrinology P2 | ESPE2016

The Effects of Serum Insulin, Leptin, Ghrelin, Adiponectin and Resistin Levels on Early Postnatal Growth in Small for Gestational Age Newborns

Orbak Zerrin , Kara Mustafa

Background: Adipose tissue acts as an endocrine organ, secreting biologically active molecules in response to external stimuli or lipid overloading. These adipose tissue-derived signaling molecules include adipokines such as leptin, adiponectin and resistin (4). On the other hand, ghrelin is the hunger hormone and an endogenous growth hormone secretagogue.Objective and hypotheses: This study aimed to investigate the relation between weight gain and serum...

hrp0086p2-p579 | Perinatal Endocrinology P2 | ESPE2016

The Effects of Serum Leptin, Ghrelin, Adiponectin and Resistin Levels on Early Postnatal Growth in Infants of Diabetic Mothers

Kara Mustafa , Orbak Zerrin

Background: The exact mechanisms on growth are not fully eluciated, but they involve insulin resistance, fetal hyperleptinemia, hypothalamic changes. The adipose tissue-derived signaling molecules include adipokines such as leptin, adiponectin and resistin. On the other hand, ghrelin is the hunger hormone and an endogenous growth hormone secretagogue.Objective and hypotheses: This study aimed to investigate the relation between growth and serum insulin, ...

hrp0092p1-81 | GH and IGFs | ESPE2019

Effect of Recombinant Growth Hormone Therapy on Retinal Nerve Fiber in Children with Idiopathic Growth Hormone Deficiency

Çinici Emine , Orbak Zerrin

Introduction: Growth hormone (hGH) and/or growth factors are thought to play a role in the pathogenesis of diabetic retinopathy. Increased treatment of human growth hormone (hGH) in children rise questions concerning the safety of GH replacement therapy on ophtalmic changes. Adverse effects of hGH treatment (pseudotumor cerebri, papilloedema, retinal changes mimicking diabetic retinopathy, neovascularization) have been reported in some papers. In this study, i...

hrp0084p3-670 | Bone | ESPE2015

A Cause of Severe Hypercalcaemia: Overdose or Hypersensitivity to Vitamin D?

Orbak Zerrin , Yesilcibik Remziye Seda , Unal Bahri

Background: Hypercalcaemia is caused by many different conditions. Vitamin D intoxication with severe hypercalcemia is rare in the neonatal and infancy period. Here we described a 4-month-old male with severe hypercalcemia secondary to taking oral 600 000 units of vitamin D. He was diagnosed vitamin D 24-hydroxylase gene (CYP24A1) mutation after evaluation.Case presentat─▒on: He was admitted to our hospital with high serum calcium level (23 mg/dl). S...

hrp0092lb-6 | Late Breaking Posters | ESPE2019

Can Different Diets (High Fat and High Fructose Diet) Affect Insulin Resistance, Tissue Advanced Glycation End Product Levels in Rats' Pancreas

Orbak Zerrin , Demirci Tuba , Ozturk Nurinnisa , Alaca Raziye

Introduction & Objectives: High consumption of processed foods rich in fat and sugar are associated with the increasing prevalence of metabolic disturbances like obesity, insülin resistance, dyslipidemia, type 2 diabetes mellitus. In the present study, we aimed to investigate the relationship between advanced glycation end products and metabolic disorders such as insulin resistance caused by high fructose and high-fat diet, and also examine histologic...

hrp0092p3-61 | Diabetes and Insulin | ESPE2019

The Effect of Fibroblast Growth Factor 23 on Serum Phosphorus Level in Children with Diabetic Ketoacidosis

Doneray Hakan , Ozay Mustafa , Ozden Ayse , Ozturk Nurinnisa , Orbak Zerrin

Aim: The pathophysiology of developing hypophosphatemia in children with diabetic ketoacidosis (DKA) has not been sufficiently elucidated. Fibroblast Growth Factor 23 (FGF23) is a hormone that causes phosphate excretion from the kidneys. The increase of FGF23 in children with DKA may explain the pathophysiology of hypophosphatemia in these children. The aim of our study was to investigate the effect of serum FGF23 on serum phosphorus level in children with DKA...

hrp0089p2-p373 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P2 | ESPE2018

Prevalence and Ethiologic Factors of Hirsutism in Adolescents

Kaplan Nılgun , Orbak Zerrin , Doneray Hakan

Aim: To investigate the prevalence of hirsutism among adolescents using the modified Ferriman-Gallway (FG) Scale and to determine etiological factors in childen with hirsutism.Materials and methods: The study was in 2380 female adolescents aged 12┬ľ18 years. The modified FG score was used in the diagnosis and monitoring of hirsutism. Scores of 8 or above were regarded as hirsutism. Two hundred thirty-three volunteers determined as having hirsutism we...

hrp0086p2-p576 | Perinatal Endocrinology P2 | ESPE2016

The Postnatal Effect of Serum Vitamin D Binding Protein on Serum Vitamin D Level

Doneray Hakan , Yesilcibik Remziye Seda , Laloglu Esra , Orbak Zerrin

Background: It is not an uncommon situation that newborns have normal serum Ca, P, Mg, ALP, and PTH levels despite low vitamin D. Serum vitamin D binding protein (VDBG) may play a role for this situation. However, there is no any study investigated the relationship between serum vitamin D and VDBP in postnatal period.Objective and hypotheses: The aim of this study is to examine the relationship between serum vitamin D level and VDBP in neonates who have ...