ESPE Abstracts

Background: Abnormal birth weight, either small- or large for gestational age, has been influenced on long term heath. Previous data demonstrated small for gestational age infants have greater risk for developed obesity and metabolic diseases later in life but little was known in large for gestational age (LGA) babies.Objective: To study the growth pattern of children born large for gestational age from birth until age o...

Background: Mauriac syndrome, a rare complication of type I diabetes mellitus (T1DM) results from inadequate glycemic control and excessive insulin therapy. Fluctuating plasma glucose, excessive insulin and glucose administration stimulate glycogen synthase, causing glycogen accumulation in the liver. Furthermore, elevated serum cortisol secretion in Mauriac syndrome inhibits hepatic glycogenolysis while enhancing fatty acid synthesis, worsening liver enlargem...

Background: Triglyceride glucose (TyG) index, a product of fasting triglyceride and glucose, was widely used as an alternative tool for identifying insulin resistance in adults but not in children. Recent study in children showed association between the TyG index and HOMA-IR and a usefulness of TyG index as a surrogate marker of insulin resistance among adolescents.Objective: To evaluated the potential role of the TyG index as a predictor of impaired glu...

Background: Gonadotropin-releasing hormone analogs (GnRHa) are the standard treatment of central precocious puberty (CPP). Many studies demonstrate the effects of GnRHa on preserved final adult height. However, data compares the efficacy of different GnRHa on growth outcome and gonadotropin suppression in girl with CPP was limitObjective: Evaluate the effect of 2 different GnRHa on final adult height (FAH) and gonadotropin suppression in girl with CPP</p...

Background: Precocious puberty (PP) in girls is defined by the appearance of secondary sex characteristic before the age of 8 years. Numerous studies reported no deficit of final adult height in girls with pubertal onset between 6-8 years compared with their genetic height, however, there were limited studies on the aspect of psychological outcomes of PP girls compare with the same age prepubertal girls.Objective: To eva...

Background: Adipokines have been demonstrated to regulate bone metabolism and impact bone strength. Previous studies have investigated the potential influence of leptin and adiponectin on the risks of vertebral fracture (VF) and bone mineral density (BMD) in healthy children and postmenopausal women, however, the outcomes of these investigations remain controversy.Objectives: To determine plasma leptin and adiponectin le...

Background: Craniopharyngiomas are the commonest pituitary tumours of childhood. Though benign histologically, their localisation and invasive tendency can cause significant neuroendocrine morbidity and late mortality.Objective and hypotheses: To prospectively determine risk factors for neuroendocrine morbidity by longitudinal survival analysis.Method: All children with craniopharyngioma newly presenting to our quaternary centre be...