hrp0082p1-d2-252 | Thyroid (1) | ESPE2014

Autoimmune Encephalopathy in a Boy with Graves’ Disease

Kucharska Anna , Kadziela Katarzyna , Pyrzak Beata

Background: Autoimmune encephalopathy is usually reported in patient with Hashimoto’s thyroiditis and in Graves’ disease is rather rare, especially in children.Method: We report a boy of 15 years diagnosed with Graves’ disease and treated ineffectively with thyrostatics. After 2 years of the therapy he had recurrence of hyperthyroidism and underwent radical treatment with ablative dose of 131I. After 2 weeks the patient suffered...

hrp0084p1-77 | Fat | ESPE2015

Evaluation of Adiponectin Concentrations in Obese Children and Its Correlation with Lipid and Carbohydrate Parameters

Ruminska Malgorzata , Majcher Anna , Pyrzak Beata

Aims: The aims of the study was to evaluate the plasma adiponectin levels in obese children depending on children age, gender, stage of puberty and its relationship with lipid and carbohydrate metabolism parameters.Material and method: The study were involved 122 obese children (52 girls, 70 boys), aged 5.3–17.9 years (11.6±3 years), 52 children in prepubertal, and 65 in pubertal period. Obesity was defined using IOTF criteria. The control grou...

hrp0086p2-p153 | Bone & Mineral Metabolism P2 | ESPE2016

Evaluation of ALP Value in Early Prediction of the Effects of Growth Hormone Treatment in Children with Growth Hormone Deficiency (GHD)

Witkowska-Sedek Ewelina , Kucharska Anna , Majcher Anna , Pyrzak Beata

Background: Serum bone turnover markers may serve as parameters for predicting the growth response to growth hormone (rhGH) treatment.Objective and hypotheses: Assessment of the alkaline phosphatase (ALP) value in early prediction of the effects of rhGH treatment in children with growth hormone deficiency.Method: The study group consisted of 50 children with GHD. ALP, bone-ALP, vitamin D and I...

hrp0086p2-p949 | Thyroid P2 | ESPE2016

Thyroid Function in Obese Children and Its Correlations with Chosen Atherogenic Risk Factors

Ruminska Malgorzata , Witkowska-Sedek Ewelina , Majcher Anna , Pyrzak Beata

Background: Moderately elevated thyroid-stimulating hormone (TSH) with normal serum concentrations of free thyroxine (fT4), suggesting subclinical hypothyroidism, is the most common hormonal abnormality in obese children. Controversy remains whether thyroid dysfunction related to obesity has an influence on the cardiovascular risk factors.Objective and hypotheses: The aim of the study was to assess correlation between TSH and fT4 and chosen atherogenic r...

hrp0084p3-916 | GH & IGF | ESPE2015

Vitamin D Deficiency can Modulate GH/IGF1 Axis in GH Deficient Children

Witkowska-Sedek Ewelina , Kucharska Anna , Majcher Anna , Pyrzak Beata

Background: According to the latest studies vitamin D has an effect on the production and/or secretion of IGF1 in the liver, but the exact mechanism regulating these relationships has not been thoroughly explained.Objective and hypotheses: Evaluation of the relationship between 25(OH)D and IGF1 levels in the serum of children with GH deficiency (GHD).Method: The study group consisted of 76 GH deficient children qualified for GH the...

hrp0092p1-73 | GH and IGFs | ESPE2019

Influence of Birth Parameters on Growth Response and Metabolic Effects of Growth Hormone (GH) Therapy in GH-deficient Children and Adolescents

Witkowska-Sedek Ewelina , Ruminska Malgorzata , Kucharska Anna M. , Majcher Anna , Pyrzak Beata

Introduction: Growth depends on growth hormone (GH) secretion and on individual sensitivity to its action. The effects of birth parameters on growth and metabolic status are well documented in small-for-gestational-age children, but in children with GH deficiency those associations are not clear. Taking into account that GH-deficient children are not a homogenic group of patients, the importance of an individual approach to GH doses and the assessment of the e...

hrp0089p3-p363 | Thyroid P3 | ESPE2018

Acquired Severe Hypothyroidism in Children – Forgotten or Unbelievable Diagnosis in a Time of Large and Easy Availability of Thyroid Tests?

Kucharska Anna , Labochka Dominika , Borowiec Ada , Witkowska- Sedek Ewelina , Pyrzak Beata

In a time of widespread availability of thyroid lab tests plenty of patients are reported to endocrine clinics because of isolated slightly increased TSH value and many papers are dedicated disscussion of precautions to treatment in subclinical hypothyroidism. Simultaneously in the same places other patients develop severe hypothyroidism without proper diagnosis. What is the reason of missing diagnoses?The Aim: Clinical characteristics of severe hypothyr...

hrp0082p2-d2-431 | Growth Hormone (1) | ESPE2014

Vitamin D Concentrations in Children with GH Deficiency During First Year of GH Treatment

Pyrzak Beata , Witkowska-Sedek Ewelina , Kucharska Anna , Sagala Magdalena , Majcher Anna

Introduction: The start of GH (rhGH) treatment in children with GH deficiency (GHD) causes a significant increase in bone turnover and increases height velocity. The increase in IGF1 concentrations during rhGH treatment is a marker of the efficiency of treatment. A significant increase in bone turnover during rhGH treatment results in an increased demand for vitamin D. It is important to determine proper supplementation doses of vitamin D in patients during catch-up growth.</p...

hrp0084p3-1195 | Thyroid | ESPE2015

The Evaluation of CD8+CD122+T Cells in Children with Autoimmune Thyroiditis

Kucharska Anna , Stelmaszczyk-Emmel Anna , Popko Katarzyna , Pyrzak Beata , Kadziela Katarzyna

Background: The basic subset of T cells playing a major role in the pathogenesis of Hashimoto’s thyroiditis are CD8+T cells. The mechanism of disease initiation is dysfunction of natural Tregs leading to breakdown of the self-tolerance. The best known subset of natural Tregs are CD4+Foxp3+T, but CD8+T cells expressing CD122 were also recognized as functional Treg cells.Objective and hypotheses: The aimof the study was to evaluate the contribution of...

hrp0094p2-462 | Thyroid | ESPE2021

Growth impairment in children with severe autoimmune primary hypothyroidism and pituitary hyperplasia without goiter

Corica Domenico , Kucharska Anna Malgorzata , Vierucci Francesco , Valenzise Mariella , Li Pomi Alessandra , Tuli Gerdi , Munarin Jessica , Pyrzak Beata , Cesaretti Graziano , Aversa Tommaso , Wasniewska Malgorzata

Background: Prolonged severe hypothyroidism due to Hashimoto’s thyroiditis (HT) is a rare cause of pituitary hyperplasia (PH) in children. Loss of thyroxine negative feedback causes a TRH-dependent hyperplasia of pituitary thyrotroph cells resulting in adenohypophysis enlargement. A transdifferentiation of pituitary somatotroph cells into thyrotroph cells could explain growth failure in those patients. We report a case series of patients with growth impairment diagnosed...